ChemicalBook > CAS DataBase List > 1-(2-Chloroethyl)azepane hydrochloride

1-(2-Chloroethyl)azepane hydrochloride

Product Name
1-(2-Chloroethyl)azepane hydrochloride
CAS No.
26487-67-2
Chemical Name
1-(2-Chloroethyl)azepane hydrochloride
Synonyms
Bazedoxifeno int;BAZEDOXIFENE int1;2-CHLOROETHYLHEXAMETHYLENE IMINE HCL;2-ChloroethylhexamethyleneImineHcl99%;1-(2-Chloroethyl)azepane hydrochloride;N-(2-Chloroethyl)azepane hydrochloride.;2-Chloroethylhexamethylene Imine Hcl 99%;azepin-1-yl)ethyl chloride hydrochloride;2-(HEXAMETHYLENEIMINO)ETHYL CHLORIDE HCL;1-(2-Chloroethyl)azepanehydrochloride98%
CBNumber
CB5693188
Molecular Formula
C8H17Cl2N
Formula Weight
198.13
MOL File
26487-67-2.mol
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1-(2-Chloroethyl)azepane hydrochloride Property

Melting point:
208-210°C
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to crystal
color 
White to Almost white
Sensitive 
Hygroscopic
BRN 
3680388
InChI
InChI=1S/C8H16ClN.ClH/c9-5-8-10-6-3-1-2-4-7-10;/h1-8H2;1H
InChIKey
ZQDSOUPBYJIPNM-UHFFFAOYSA-N
SMILES
N1(CCCl)CCCCCC1.Cl
CAS DataBase Reference
26487-67-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
20/22-36/37-39-52-22-36/38-20
Safety Statements 
22-26-36/37/39-51-20/21
RIDADR 
2811
RTECS 
CM3185000
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29339900
Toxicity
mouse,LD50,intravenous,56mg/kg (56mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00612,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2379
Product name
1-(2-Chloroethyl)-1H-hexahydroazepine Hydrochloride
Purity
>98.0%(T)
Packaging
5g
Price
$23
Updated
2025/07/31
TCI Chemical
Product number
C2379
Product name
1-(2-Chloroethyl)-1H-hexahydroazepine Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$58
Updated
2025/07/31
TRC
Product number
C382485
Product name
1-(2-Chloroethyl)azepaneHydrochloride
Packaging
500mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
084387
Product name
1-(2-Chloroethyl)azepane hydrochloride
Purity
97%
Packaging
1g
Price
$14
Updated
2021/12/16
Matrix Scientific
Product number
084387
Product name
1-(2-Chloroethyl)azepane hydrochloride
Purity
97%
Packaging
5g
Price
$35
Updated
2021/12/16
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1-(2-Chloroethyl)azepane hydrochloride Chemical Properties,Usage,Production

Uses

1-(2-Chloroethyl)azepane hydrochloride is a key intermediate of bazedoxifene and setastine.

Synthesis

2205-31-4

26487-67-2

General procedure for the synthesis of 2-(cyclohexylimino)ethyl chloride hydrochloride from 1-(2-chloroethyl)azepane: 165.9 g of isopropanol was added to the reaction system, and dry hydrogen chloride gas was slowly vented under stirring until the pH of the reaction system was ≤2.5 when the venting was stopped. The reaction mixture was heated to a maximum of 80 °C with continuous stirring for 30 minutes. Subsequently, 2.8 g of activated carbon was added and stirring was continued for 30 minutes. Upon completion of the reaction, thermal filtration was performed to remove the activated carbon. The filtrate was cooled to 0-5°C and left to crystallize for 8 hours. Upon completion of crystallization, the solid product was collected by filtration and dried to give 53.1 g of N-(2-chloroethyl)hexamethyleneimine hydrochloride in 84.5% yield. The purity of the product N-(2-chloroethyl)hexamethyleneimine hydrochloride was tested to be 98.6%.

References

[1] Patent: CN104693144, 2016, B. Location in patent: Paragraph 0030; 0033

1-(2-Chloroethyl)azepane hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-Chloroethyl)azepane hydrochloride Suppliers

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View Lastest Price from 1-(2-Chloroethyl)azepane hydrochloride manufacturers

Chongqing Soarwin Technology Co., Ltd
Product
1-(2-Chloroethyl)azepane hydrochloride 26487-67-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
20 tons
Release date
2025-04-11
Weijer International Trade (Hebei) Co., Ltd
Product
1-(2-Chloroethyl)azepane hydrochloride (1:1) 26487-67-2
Price
US $20.00/KG
Min. Order
1KG
Purity
>99%
Supply Ability
50000kg/Month
Release date
2023-03-17
Anhui Rencheng Technology Co., Ltd
Product
1-(2-Chloroethyl)azepane hydrochloride (1:1) 26487-67-2
Price
US $10.00/KG
Min. Order
0.5KG
Purity
>99%
Supply Ability
20tons
Release date
2020-12-28

26487-67-2, 1-(2-Chloroethyl)azepane hydrochlorideRelated Search:

1-(2-CHLOROETHYL) HEXAMETHYLENIMINE ACETIC ACID 2,2-DICHLORO-1-(2-OXO-AZEPAN-1-YL)-ETHYL ESTER 2-Chloroethyldimethylamine 2-Dimethylaminoethyl chloride hydrochloride 1-(2,2-DICHLORO-1-HYDROXY-ETHYL)-AZEPAN-2-ONE 1-ETHYLHOMOPIPERAZINE Hexamethyleneimine N-METHYLHEXAMETHYLENEIMINE 2-Diethylaminoethylchloride hydrochloride (2-CHLORO-ETHYL)-DIETHYL-AMINE 2-(HEXAMETHYLENEIMINO)ETHYL CHLORIDE HYDROCHLORIDE

  • 1-(2-chloroethyl)-hexahydro-1h-azepinehydrochloride
  • hexahydro-1-(2-chloroethyl)-1h-azepinhydrochloride
  • 2-CHLOROETHYLHEXAMETHYLENE IMINE HCL
  • 2-CHLOROETHYLHEXAMETHYLENEMINE HYDROCHLORIDE
  • 2-(HEXAMETHYLENEIMINO)ETHYL CHLORIDE HYDROCHLORIDE
  • 2-ChloroethylhexamethyleneImineHcl99%
  • 2-Chloroethylhexamethylene Imine Hcl 99%
  • N-(2-CHLOROETHYL)HEXAHYDRO-1H-AZEPINE HYDROCHLORIDE
  • N-(2-chloroethyl)perhydroazepine hydrochloride
  • 1-(2-Chloroethyl)azepane hydrochloride
  • N-(2-Chloroethyl)azepane hydrochloride.
  • 1-(2-Chloroethyl)azepane hydrochloride 98%
  • 2-(hexamethyleneimino)ethyl chloride monohydrochloride
  • 1-(2-Chloroethyl)-1H-hexahydroazepine Hydrochloride
  • 2-(Hexamethyleneimino)ethyl chloride hydrochloride,98%
  • 2-(Hexamethyleneimino)ethyl chloride hydrochloride, 1-(2-Chloroethyl)hexahydro-1H-azepine hydrochloride, 1-(2-Chloroethyl)homopiperidine hydrochloride, 1-(Azepan-1-yl)-2-chloroethane hydrochloride
  • 1-(2-Chloroethyl)hexamethyleneimine Hydrochloride
  • azepin-1-yl)ethyl chloride hydrochloride
  • 2-(HEXAMETHYLENEIMINO)ETHYL CHLORIDE HCL
  • 1-(2-Chloroethyl)azepanehydrochloride98%
  • 2-Chloroethyl hexamethylene Imine hydrochloride
  • BAZEDOXIFENE int1
  • Bazedoxifeno int
  • 2-chloro-N-(6-chlorohexyl)ethanimine hydrochloride
  • 1-(2-Chloroethyl)-1H-hexahydroazepineHydrochloride&gt
  • 1H-Azepine, 1-(2-chloroethyl)hexahydro-, hydrochloride (1:1)
  • 1-(2-Chloroethyl)azepane hydrochloride (1:1)
  • Hexamethylenimineethylchloride hydrochloride
  • 1-(2-Chloroethyl)azepane hydrochloride 26487-67-2
  • 1-(2-chloroethyl)hexahydro-1H-Azepine hydrochloride (1:1)
  • Hexahydro-1-(2-chloroethyl)-1H-azepine hydrochloride
  • 26487-67-2
  • C8H17NCl2
  • C8H16ClNClH
  • C8H17Cl2N
  • Miscellaneous