5-ALPHA-ANDROSTANE Property

Melting point:

50-50.5°

alpha 

D16 +2° (c = 1.2 in chloroform)

Boiling point:

336.0±9.0 °C(Predicted)

Density 

0.950±0.06 g/cm3(Predicted)

storage temp. 

room temp

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

CAS DataBase Reference

438-22-2(CAS DataBase Reference)

EPA Substance Registry System

Androstane, (5.alpha.)- (438-22-2)

Safety

Hazard Codes 

T,Xn

Risk Statements 

45-23/24/25-36/37/38-43-63-67-40

Safety Statements 

53-23-24/25-36/37

RIDADR 

UN 1593 6.1/PG 3

WGK Germany 

3

HS Code 

29372290

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P281Use personal protective equipment as required.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

5-ALPHA-ANDROSTANE Chemical Properties,Usage,Production

Uses

5alpha-Androstane is an anabolic steroid.

Definition

ChEBI: 5alpha-androstane is the 5alpha-stereoisomer of androstane. It has a role as a human metabolite.

Purification Methods

Purify 5-androstane by chromatography through Al2O3 (grade III) and elute with pet ether and recrystallise from MeOH (2x) and Me2CO/MeOH. It sublimes at 60o/high vacuum. Also dissolve it in pet ether, filter it through silica gel, evaporate and recrystallise it. [Steiger & Reichstein Helv Chim Acta 20 817 1937, Prelog et al. Helv Chim Acta 27 66 1944, IR, NMR: Halkes & Havinga Rec Trav Chim Pays-Bas 8 4 889 1965, Allinger et al. Tetrahedron 27 5073 1971, Beilstein 5 III 1110, 5 IV 1211.]