METHYL 2,3-DICHLOROBENZOATE

METHYL 2,3-DICHLOROBENZOATE Property

Melting point:

33-38 °C

Boiling point:

294.45°C (rough estimate)

Density 

1.36

refractive index 

1.5537

Flash point:

110 °C

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

EPA Substance Registry System

Benzoic acid, 2,3-dichloro-, methyl ester (2905-54-6)

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

HS Code 

29163900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

METHYL 2,3-DICHLOROBENZOATE Chemical Properties,Usage,Production

Chemical Properties

white crystals

Synthesis

a) 2,3-Dichlorobenzoic acid (100 g, 0.526 mol) was dissolved in methanol (1 L) and concentrated sulfuric acid (20 mL) was added slowly. The reaction mixture was stirred under reflux conditions for 12 hours. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove most of the solvent. The residue was diluted with ethyl acetate (1 L) and water (100 mL) and the organic layer was separated. The organic phase was washed sequentially with saturated sodium bicarbonate solution and brine and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to afford methyl 2,3-dichlorobenzoate (99 g, 92% yield) as a white solid.1H NMR (300 MHz, CDCl3) δ ppm: 3.95 (s, 3H), 7.27 (t, J = 7.8 Hz, 1H), 7.60 (dd, J = 1.8, 7.8 Hz, 1H), 7.66 (dd, J = 1.8, 7.8 Hz, 1H).

References

[1] Patent: WO2013/28263, 2013, A1. Location in patent: Page/Page column 78
[2] Patent: US9096605, 2015, B2
[3] Patent: EP459830, 1991, A1