Cloxacillin-13C4 SodiuM Salt

ChemicalBook > CAS DataBase List > Cloxacillin-13C4 SodiuM Salt

Cloxacillin-13C4 SodiuM Salt

Product Name: Cloxacillin-13C4 SodiuM Salt
CAS No.: 642-78-4
Chemical Name: Cloxacillin-13C4 SodiuM Salt
Synonyms: cloxapen;Sodium cloxacillin;Cloxacillin sodium salt;CLOXACILLIN SODIUM SALT HYDRATE;3-(o-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin sodium salt;5R;(2S;2-DPPE;tegopen;Orbenin
CBNumber: CB5705412
Molecular Formula: C19H19ClN3NaO5S
Formula Weight: 459.88
MOL File: 642-78-4.mol

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Cloxacillin-13C4 SodiuM Salt Property

Melting point:: 170°C
storage temp.: 2-8°C
solubility: H₂O: 50 mg/mL, clear, colorless
form: Solid
color: White to Off-White
Water Solubility: Soluble in water
BCS Class: 3
Stability:: Stable. Incompatible with strong oxidizing agents. Refrigerate.
CAS DataBase Reference: 642-78-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-42/43
Safety Statements: 26-36-22
WGK Germany: 2
RTECS: XH8920000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 27555
Product name: Cloxacillin sodium salt
Purity: ≥95.0% (HPLC)
Packaging: 1G
Price: $67.2
Updated: 2023/06/20

Sigma-Aldrich

Product number: 27555
Product name: Cloxacillin sodium salt
Purity: ≥95.0% (HPLC)
Packaging: 5G
Price: $270
Updated: 2023/06/20

Alfa Aesar

Product number: J64314
Product name: Cloxacillin sodium salt
Packaging: 1g
Price: $51.65
Updated: 2024/03/01

Alfa Aesar

Product number: J64314
Product name: Cloxacillin sodium salt
Packaging: 5g
Price: $148.65
Updated: 2024/03/01

Cayman Chemical

Product number: 22249
Product name: Cloxacillin (sodium salt)
Purity: ≥95%
Packaging: 5g
Price: $73
Updated: 2024/03/01

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Cloxacillin-13C4 SodiuM Salt Chemical Properties,Usage,Production

Description

Cloxacillin is a β-lactam antibiotic and a derivative of oxacillin . It is active against clinical isolates of the Gram-positive bacteria S. aureus and S. epidermidis (MICs = 0.004-0.4 and 0.1-0.8 μg/ml, respectively) but not 34 Gram-negative bacteria (MICs = >128 μg/ml for all). Cloxacillin binds to S. aureus penicillin-binding protein 1 (PBP1), PBP2, PBP3, and PBP4 (IC₅₀s = 0.04, 0.12, 0.21, and 2.5 μg/ml, respectively). It also binds to recombinant type Ib penicillinase, as well as P. vulgaris and C. freundii cephalosporinase (K_is = 15, 0.27, and 0.027 μM, respectively). Cloxacillin decreases the number of staphylococci in the mammary gland in a mouse model of acute, but not chronic, mastitis induced by Staphylococcus infection.

Chemical Properties

White Crystalline Powder

Originator

Orbenin,Beecham,UK,1962

Uses

Labelled S-Form of Dropropizine. Cough suppressive phenylpiperazine derivative. Antitussive.

Uses

Ropivacaine (R675000) metabolite.

Uses

Cloxacillin-13C4 SodiuM Salt is an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lactamase due to its inhibitory effects on beta-lactamase binding.

Uses

Cloxacillin-13C4 SodiuM Salt, an antibiotic that belongs to the group of the isoxazolylpenicillins. Cloxacillin is used to treat infections caused by species of staphylococci that produce beta-lac tamase due to its inhibitory effects on beta-lactamase binding.

Definition

ChEBI: Cloxacillin sodium is an organic sodium salt. It contains a cloxacillin(1-).

Manufacturing Process

The reaction between 6-aminopenicillanic acid (6.5 g) and 3-o-chlorophenyl-5- methylisoxazole4-carbonyl chloride (7.66 g) gave the sodium salt of 3-ochlorophenyl-5-methyl-4-isoxazolylpenicillin (9.98 g) as a pale yellow solid. Colorimetric assay with hydroxylamine against a benzylpenicillin standard indicated a purity of 68%.
The 3-o-chlorophenyl-5-methylisoxazole-4-carboxylic acid, from which the acid chloride was prepared, was obtained by hydrolysis of the ester product of the reaction between o-chlorobenzohydroxamic chloride and ethyl acetoacetate in methanolic sodium methoxide. Reaction with thionyl chloride gave the starting material.

brand name

Cloxapen (GlaxoSmithKline); Tegopen (Apothecon).

Therapeutic Function

Antibacterial

Purification Methods

Purify cloxacillin sodium salt by dissolving it in isoPrOH containing 20% of H2O, and diluting with isoPrOH to a water content of 5% and chilling. Recrystallise it again in this manner. The sodium salt is collected and dried at 40o in air to give the colourless monohydrate. It is soluble in H2O (5%), MeOH, EtOH, pyridine and ethylene glycol. [Doyle et al. J Chem Soc 5838 1963, Naylor et al. Nature 195 1264 1962.] ( ) -Cocaine {ecogonine methyl ester benzoate, 2 -carbomethoxy-3--benzoxytropane, methyl 1R -(exo,exo)]-3-(benzoyloxy)-2-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate}

Cloxacillin-13C4 SodiuM Salt Preparation Products And Raw materials

Raw materials

Preparation Products

Sodium cloxacillin monohydrate

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View Lastest Price from Cloxacillin-13C4 SodiuM Salt manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cloxacillin Sodium Salt 642-78-4
Price: US $0.00/KG/CTN
Min. Order: 5KG
Purity: 825μg/mg; USP
Supply Ability: 500KGS
Release date: 2021-07-23

Hebei Chuanghai Biotechnology Co,.LTD

Product: Cloxacillin Sodium 642-78-4
Price: US $10.50/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 1 ton
Release date: 2024-08-22

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Cloxacillin Sodium 642-78-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-04-07

642-78-4, Cloxacillin-13C4 SodiuM SaltRelated Search:

N,N-Dimethyl-1,4-phenylenediamine Methanol Kresoxim-methyl Methyl acrylate Sodium acetate Sodium hydroxide Methylparaben Trisodium phosphate Cloxacillin Methyl cellulose PYRAZOPHOS METSULFURON METHYL Oxacillin sodium monohydrate Bensulfuron methyl Sulfamethoxazole Fenoxaprop-p-ethyl Chlorodimethylphenylsilane Flucloxacillin sodium

austrastaph

prostaphlina

sodiumorbenin

sodiumsyntarpen

staphybiotic

syntarpensodiumsalt

tegopen

CLOXACILLIN SODIUM SALT HYDRATE

CLOXACILLIN SODIUM SALT MONOHYDRATE

CLOXACILLIN SODIUM SALT N-HYDRATE

[5-METHYL-3-(O-CHLOROPHENYL)-4-ISOXAZOLYL]PENICILLIN SODIUM SALT MONOHYDRATE

4-Acetyloxy-N-despropyl Ropivacaine

(2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-Methyl-4-isoxazolyl]carbonyl]aMino]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid SodiuM Salt

(2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-Methyl-4-isoxazolyl]carbonyl]aMino]-3,3-diMethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid-13C4 SodiuM Salt

3-(o-Chlorophenyl)-5-Methyl-4-isoxazolylpenicillin-13C

Cloxacillin-13C4 SodiuM Salt

(S)-(-)-Dropropizine-d4

3-dimethyl-7-oxo-thyl-4-isoxazolecarboxamido)-monosodiumsalt

3-o-chlorophenyl-5-methyl-4-isoxazolylpenicillinsodium

ankerbin

Thiazole sodium chloride

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, sodium salt (1:1), (2S,5R,6R)-

sodium 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]-oxomethyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

brl-1621sodiumsalt

cloxapen

ekvacillin

gelstaph

monosodiumcloxacillin

orbeninsodium

prevencilinap

prostaphilina

4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-3-(2-chlorophenyl)-5-methyl-4-isoxazolylcarbonylamino-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)-

3-(o-Chlorophenyl)-5-methyl-4-isoxazolylpenicillin sodium salt

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-(2α,5α,6β)]-

4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido]-3,3-dimethyl-7-oxo-, monosodium salt (8CI)

Orbenin

Sodium 3-(O-chlorophenyl)-5-methyl-4-isoxazolylpenicillin

SODIUMCLOXACILLIN(ANHYDROUS)

(2S

(2S,5R,6R)-6-[[[3-(2-Chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monosodium salt

CLOXACILLINSODIUMPOWDER/COMPACTED/STERILELYOPHILED

(2S,5R)-6α-[[[3-(2-Chlorophenyl)-5-methylisoxazol-4-yl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid sodium salt

Cloxacillin sodium anhydrous

Cloxacillin sodium salt

Sodium cloxacillin

Cloxacillin-13C4 SodiuM Salt USP/EP/BP

Cloxacillin-13C4 Sodium SaltQ: What is Cloxacillin-13C4 Sodium Salt Q: What is the CAS Number of Cloxacillin-13C4 Sodium Salt

4S)-Sacubitril

2-Dipalmitoyl-sn-glycero-3-PE

2-Dipalmitoyl-sn-glycerol-3-Phosphoethanolamine

2-DPPE

Oxacillin Impurity 5 Sodium Salt (Cloxacillin Sodium Salt)

Phenylbutazone Impurity 30

Oxacillin EP Impurity E(Sodium salt)

Oxacillin Impurity 17 Sodium Salt

642-78-4

C19H17ClN3NaO5S