Tanshinone IIA
- Product Name
- Tanshinone IIA
- CAS No.
- 568-72-9
- Chemical Name
- Tanshinone IIA
- Synonyms
- Tanshinone 2A;tanshiones;SweetOrange;Tanshine II;Tanshinone B;ANSHINONE ⅡA;Tanshionesiia;TANSHINONE A;2A tanshinone;ATanshinoneⅡA
- CBNumber
- CB5705548
- Molecular Formula
- C19H18O3
- Formula Weight
- 294.34
- MOL File
- 568-72-9.mol
Tanshinone IIA Property
- Melting point:
- 196.0 to 200.0 °C
- Boiling point:
- 480.7±44.0 °C(Predicted)
- Density
- 1.209±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- methanol: soluble5mg/mL, clear, red-orange to red
- form
- powder, red
- color
- Orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChIKey
- HYXITZLLTYIPOF-UHFFFAOYSA-N
- LogP
- 4.925 (est)
- CAS DataBase Reference
- 568-72-9(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- SF8282695
- HS Code
- 29321900
- Hazardous Substances Data
- 568-72-9(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- PHL89320
- Product name
- Tanshinone IIA
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $229
- Updated
- 2024/03/01
- Product number
- 1643339
- Product name
- Tanshinone IIA
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 20mg
- Price
- $263
- Updated
- 2024/03/01
- Product number
- 51704
- Product name
- Tanshinone IIA
- Purity
- analytical standard
- Packaging
- 10mg
- Price
- $173
- Updated
- 2022/05/15
- Product number
- T2987
- Product name
- Tanshinone IIA
- Purity
- >97.0%(HPLC)
- Packaging
- 10mg
- Price
- $145
- Updated
- 2024/03/01
- Product number
- T2987
- Product name
- Tanshinone IIA
- Purity
- >97.0%(HPLC)
- Packaging
- 50mg
- Price
- $494
- Updated
- 2024/03/01
Tanshinone IIA Chemical Properties,Usage,Production
Description
Tanshinone IIA mainly exists in the roots of Salvia miltiorrhiza Bge. Traditional Chinese medicine Danshen, slightly cold and bitter, is often used for activating blood circulation and eliminating stasis in Chinese medicine. It can also promote blood circulation, open the energy channels, calm the heart, cool the blood, relieve swelling, remove twinge in the heart and stomach, and remove carbuncle and erysipelas. It is classified as high grade in Shen Nong’s Herbal Classic. It has been used as a traditional Chinese medicine in clinical practice for thousands of years. And it is not only recorded in the leading medical works through the ages but also in CP and USP.
Description
Tanshinone IIA (TSA) is a major lipophilic component of extracts from the root of S. miltiorrhiza, used widely in Chinese herbal medicine. It has anti-
Chemical Properties
Orange powder
Physical properties
Appearance: brick-red crystalline powder. Melting point: 209–210?°C. Solubility: absorbs moisture easily, very soluble in hot water, slightly soluble in methanol or ethanol, and practically insoluble in chloroform
History
The study of the chemical composition of Salvia miltiorrhiza began in the 1930s. Japanese scholars first extracted three kinds of liposoluble components from Danshen. They are tanshinones I, II, and III.
Uses
Tanshinone IIA is a derivative of Tanshinone and acts as a potential inhibitor of tumor growth in vivo. Also maintains vasodilating activity in vivo.
Uses
antineoplastic, bone resorption inhibitor, antiproliferative, apoptosis inducer
Definition
ChEBI: 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione is an abietane diterpenoid.
Synthesis Reference(s)
Journal of the American Chemical Society, 111, p. 1522, 1989 DOI: 10.1021/ja00186a070
Biochem/physiol Actions
Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Anti-inflammatory. Antioxidant. Cytotoxic against a variety of cell lines, inlcuding human glioma cells.
Pharmacology
Long-term researches show that tanshinone exhibits a variety of pharmacological effects, such as the protection of the cardiovascular system, anti-infective effects, and antioxidant effects. As for the domestic pharmacological study of tanshinone IIA, it was first started in the Shanghai Institute of Chinese Medicine. Professor Ding Guangsheng discussed the cardiovascular effects of tanshinone IIA.?He found that intraperitoneal injection of tanshinone IIA sodium sulfonate (200?mg/kg) significantly prolonged the survival time of mice under hypoxia atmosphere, and an increase in cardiac output was observed in a dog under anesthesia with a one-time intravenous injection of 20? mg/kg . In recent years, the mechanism of tanshinone IIA is increasingly brought to further research. Tanshinone IIA can increase the activity of superoxide dismutase (SOD) and interfere with the pathological process of many diseases, especially in cardiovascular diseases. It can attenuate the damages from the reactive oxygen species to vascular endothelial cells, lower the risk of atherosclerosis, and reduce the formation of atheromatous plaque. tumor cells and the expression of various genes connected with the proliferation, differentiation, and apoptosis of tumor cells. It may also have something to do with the inhibition of telomerase activity in tumor cells, changes in antigen expression on tumor cell surface, etc.
Clinical Use
Tanshinone IIA is a diterpenoid quinone liposoluble ingredient of high content, and its chemical structure is the most representative in Danshen. In addition to tanshinone IIA sodium sulfonate, there are a variety of preparations of Salvia common ketone used clinically, such as tanshinone tablets, tanshinone capsules, tanshinone injection, Danshen Shuxin capsule, compound Danshen soft capsules, and compound Danshen particles.
Cytotoxicity
IC50 (μg/mL): 0.59 (A549), 0.81 (TOV-21G) and 1.9 (MIAPaCa-2), NS (MV-3)(Chang et al. 2013; Fronza et al. 2011).
IC50 (μg/mL): 2.97 (HeLa), 2.71 (KB-3-1),>2.94 (NCI-H460), 2.62 (PC3), 2.94(MCF-7), 1.62 (K562)(Wu et al. 2014)
References
1) Kang et al. (2000), Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza; Immunopharmacology, 49 355 2) Sung et al. (1999), Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3; Exp. Mol. Med., 31 174 3) Park et al. (1999), Suppression of AP-1 Activity by Tanshinone and Cancer Cell Growth Inhibition; Bull. Korean Chem. Soc., 20 925
Tanshinone IIA Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tanshinone IIA manufacturers
- Product
- Tanshinone IIA 568-72-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-02
- Product
- Tanshinone IIA 568-72-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-11-29
- Product
- Tanshinone IIA 568-72-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 10% 40% 50% 60%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-24