LE 300
- Product Name
- LE 300
- CAS No.
- 274694-98-3
- Chemical Name
- LE 300
- Synonyms
- LE 300;6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f]benzazecine;6,7,8,9,14,15-HEXAHYDRO-7-METHYL-5H-INDOLO[3,2-F][3]BENZAZECINE;7-METHYL-6,7,8,9,14,15-HEXAHYDRO-5H-BENZ[D]INDOLO[2,3-G]AZECINE;5H-Indolo[3,2-f][3]benzazecine, 6,7,8,9,14,15-hexahydro-7-methyl-
- CBNumber
- CB5714645
- Molecular Formula
- C20H22N2
- Formula Weight
- 290.4
- MOL File
- 274694-98-3.mol
LE 300 Property
- Melting point:
- >91°C (dec.)
- storage temp.
- Store at RT
- solubility
- DMSO: 26 mg/mL
- form
- solid
- color
- Off-White to Pale Beige
- Stability:
- Hygroscopic
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 29856
- Product name
- LE300
- Packaging
- 1mg
- Price
- $36
- Updated
- 2023/06/20
- Product number
- 29856
- Product name
- LE300
- Packaging
- 5mg
- Price
- $96
- Updated
- 2023/06/20
- Product number
- 29856
- Product name
- LE300
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $174
- Updated
- 2023/06/20
- Product number
- 1674
- Product name
- LE300
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $227
- Updated
- 2021/12/16
- Product number
- L321003
- Product name
- LE300
- Packaging
- 10mg
- Price
- $215
- Updated
- 2021/12/16
LE 300 Chemical Properties,Usage,Production
Description
LE300 is a dopamine D1-like receptor antagonist (Kis = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (pA2 = 8.32 in a rat tail artery assay). It is selective for dopamine D1 and D5 over D2L and D4.4 receptors (Kis = 44.7 and 109 nM, respectively). LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED50 = 0.94 mg/kg), which is predictive for antipsychotic-like activity. It also reduces locomotor activity in the open field test in rats (ED50 = 0.74 mg/kg).
Uses
LE 300 is a potent and selective dopamine receptor antagonist.
Definition
ChEBI: LSM-2007 is a member of indoles.
Biological Activity
Potent and selective dopamine D 1 receptor antagonist (K i values are 0.08-1.9 nM and 6-45 nM for D 1 and D 2 receptors respectively). Also displays moderate affinity for the 5-HT 2A receptor (K i = 20 nM). Active in vivo .
storage
Room temperature
LE 300 Preparation Products And Raw materials
Raw materials
Preparation Products
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