ChemicalBook > CAS DataBase List > R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
- Product Name
- R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
- CAS No.
- 125941-87-9
- Chemical Name
- R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
- Synonyms
- R(+)-SCH-23390;SCH 23390(HCI);SCH 23390 hydrochlor;SCH 23390 HYDROCHLORIDE;SCH 23390 hydrochloride NEW;(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC);R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE;SCH23390 HYDROCHLORIDE; SCH-23390 HYDROCHLORIDE; R-(+)-SCH23390 HYDROCHLORIDE;R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine;(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride
- CBNumber
- CB62131148
- Molecular Formula
- C17H18ClNOHCl
- Formula Weight
- 324.24
- MOL File
- 125941-87-9.mol
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R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Property
- alpha
- +27~+31°(D/20℃)(c=0.5,DMF)
- storage temp.
- protect from light
- solubility
- H2O: >5mg/mL
- form
- solid
- color
- white
- optical activity
- [α]/D +32.1°, c = 1 in DMF(lit.)
- EPA Substance Registry System
- (5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride (125941-87-9)
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- D054
- Product name
- R(+)-SCH-23390 hydrochloride
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $115
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- D054
- Product name
- R(+)-SCH-23390 hydrochloride
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $178
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 5.05723
- Product name
- SCH 23390 Hydrochloride - CAS 125941-87-9 - Calbiochem
- Packaging
- 10MG
- Price
- $172
- Updated
- 2023/06/20
Cayman Chemical
- Product number
- 15631
- Product name
- SCH 23390 (hydrochloride)
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $141
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 15631
- Product name
- SCH 23390 (hydrochloride)
- Purity
- ≥99%
- Packaging
- 50mg
- Price
- $524
- Updated
- 2024/03/01
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R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Chemical Properties,Usage,Production
Uses
R(+)-SCH-23390 hydrochloride has been used:
- for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
- as a D1 receptor-selective antagonist for intracranial drug infusions
- as an antagonist of D1 receptor to study its effect on learning ability in fish
Uses
A selective dopamine D1 receptor antagonist.
Biological Activity
Potent D 1 antagonist (K i values are ~ 0.2, 0.3, ~ 1100, ~ 800 and ~ 3000 nM at D 1 , D 5 , D 2 , D 3 and D 4 receptors respectively). Also an agonist at 5-HT 1C/2C receptors (K i = 6.3 nM) in vitro .
Biochem/physiol Actions
R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.
storage
+4°C (desiccate)
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride manufacturers
Career Henan Chemical Co
- Product
- R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride 125941-87-9
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13
125941-87-9, R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochlorideRelated Search:
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