R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride

Product Name: R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
CAS No.: 125941-87-9
Chemical Name: R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
Synonyms: R(+)-SCH-23390;SCH 23390(HCI);SCH 23390 hydrochlor;SCH 23390 HYDROCHLORIDE;SCH 23390 hydrochloride NEW;SCH-23390 hydrochloride ，S0476;SCH-23390 hydrochloride, 10 mM in DMSO;(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC);R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE;SCH23390 HYDROCHLORIDE; SCH-23390 HYDROCHLORIDE; R-(+)-SCH23390 HYDROCHLORIDE
CBNumber: CB62131148
Molecular Formula: C17H18ClNOHCl
Formula Weight: 324.24
MOL File: 125941-87-9.mol

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R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Property

alpha: +27～+31°(D/20℃)(c=0.5,DMF)
storage temp.: protect from light
solubility: H2O: >5mg/mL
form: solid
color: white
optical activity: [α]/D +32.1°, c = 1 in DMF(lit.)
Water Solubility: water: 100mM
EPA Substance Registry System: (5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride (125941-87-9)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D054
Product name: R(+)-SCH-23390 hydrochloride
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: D054
Product name: R(+)-SCH-23390 hydrochloride
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $182.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.05723
Product name: SCH 23390 Hydrochloride - CAS 125941-87-9 - Calbiochem
Packaging: 10MG
Price: $172
Updated: 2023/06/20

Cayman Chemical

Product number: 15631
Product name: SCH 23390 (hydrochloride)
Purity: ≥99%
Packaging: 10mg
Price: $141
Updated: 2024/03/01

Cayman Chemical

Product number: 15631
Product name: SCH 23390 (hydrochloride)
Purity: ≥99%
Packaging: 50mg
Price: $524
Updated: 2024/03/01

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R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Chemical Properties,Usage,Production

Uses

R(+)-SCH-23390 hydrochloride has been used:

for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
as a D1 receptor-selective antagonist for intracranial drug infusions
as an antagonist of D1 receptor to study its effect on learning ability in fish

Uses

A selective dopamine D1 receptor antagonist.

Biological Activity

Potent D 1 antagonist (K i values are ~ 0.2, 0.3, ~ 1100, ~ 800 and ~ 3000 nM at D 1 , D 5 , D 2 , D 3 and D 4 receptors respectively). Also an agonist at 5-HT 1C/2C receptors (K i = 6.3 nM) in vitro .

Biochem/physiol Actions

R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.

in vivo

SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D₁ receptors in rodents, nonhuman primates, and humans^[1].
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat^[1].
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O₂ conditions^[5].

IC 50

D₁ Receptor: 0.2 nM (Ki); D₅ Receptor: 0.3 nM (Ki); 5-HT_2C Receptor: 9.3 nM (Ki); GIRK: 268 nM (IC₅₀)

storage

+4°C (desiccate)

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Suppliers

Canada 1 China 90 India 2 United Kingdom 2 United States 10 Global 105

Toronto Research Chemicals

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View Lastest Price from R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride manufacturers

Career Henan Chemical Co

Product: R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride 125941-87-9
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-13

125941-87-9, R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochlorideRelated Search:

SCH772984 6-(p-Nitrophenyl)pyrrolo[2,1-d][1,5]benzothiazepine 5,5-dioxide SCH 58261 2-CHLORO-5-METHYLPHENOL P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE 2-(3-Chlorophenyl)ethylamine 4-Chlorophenethylamine 2-CHLORO-4,5-DIMETHYLPHENOL [2-(3-CHLORO-PHENYL)-ETHYL]-METHYL-AMINE R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride 8-CHLORO-2,3,4,5-TETRAHYDRO-5-PHENYL-1H-3-BENZAZEPIN-7-OL-(5R) 7-CHLORO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE 2-(4-CHLOROPHENYL)-2-PHENYLETHYLAMINE HYDROCHLORIDE N,N-BIS(2-PHENYLETHYL)AMINE HYDROCHLORIDE [2-(4-CHLORO-PHENYL)-ETHYL]-METHYL-AMINE N,beta-Dimethylphenethylamine hydrochloride [2-(3-CHLORO-PHENYL)-ETHYL]-ETHYL-AMINE 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPIN-7-OL

R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE

SCH 23390 HYDROCHLORIDE

R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE

(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride

SCH 23390(HCI)

(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC)

R(+)-SCH-23390

R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

SCH23390 HYDROCHLORIDE; SCH-23390 HYDROCHLORIDE; R-(+)-SCH23390 HYDROCHLORIDE

SCH 23390 hydrochloride NEW

SCH 23390 hydrochlor

(R)-8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol hydrochloride

SCH-23390 hydrochloride, 10 mM in DMSO

SCH-23390 hydrochloride ，S0476

125941-87-9

Dopamine receptor

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