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LE 300

Product Name
LE 300
CAS No.
274694-98-3
Chemical Name
LE 300
Synonyms
LE 300;6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f]benzazecine;6,7,8,9,14,15-HEXAHYDRO-7-METHYL-5H-INDOLO[3,2-F][3]BENZAZECINE;7-METHYL-6,7,8,9,14,15-HEXAHYDRO-5H-BENZ[D]INDOLO[2,3-G]AZECINE;5H-Indolo[3,2-f][3]benzazecine, 6,7,8,9,14,15-hexahydro-7-methyl-
CBNumber
CB5714645
Molecular Formula
C20H22N2
Formula Weight
290.4
MOL File
274694-98-3.mol
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LE 300 Property

Melting point:
>91°C (dec.)
storage temp. 
Store at RT
solubility 
DMSO: 26 mg/mL
form 
solid
color 
Off-White to Pale Beige
Stability:
Hygroscopic
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29856
Product name
LE300
Packaging
1mg
Price
$36
Updated
2023/06/20
Cayman Chemical
Product number
29856
Product name
LE300
Packaging
5mg
Price
$96
Updated
2023/06/20
Cayman Chemical
Product number
29856
Product name
LE300
Purity
≥98%
Packaging
10mg
Price
$174
Updated
2023/06/20
Tocris
Product number
1674
Product name
LE300
Purity
≥98%(HPLC)
Packaging
10
Price
$227
Updated
2021/12/16
TRC
Product number
L321003
Product name
LE300
Packaging
10mg
Price
$215
Updated
2021/12/16
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LE 300 Chemical Properties,Usage,Production

Description

LE300 is a dopamine D1-like receptor antagonist (Kis = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (pA2 = 8.32 in a rat tail artery assay). It is selective for dopamine D1 and D5 over D2L and D4.4 receptors (Kis = 44.7 and 109 nM, respectively). LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED50 = 0.94 mg/kg), which is predictive for antipsychotic-like activity. It also reduces locomotor activity in the open field test in rats (ED50 = 0.74 mg/kg).

Uses

LE 300 is a potent and selective dopamine receptor antagonist.

Definition

ChEBI: LSM-2007 is a member of indoles.

Biological Activity

Potent and selective dopamine D 1 receptor antagonist (K i values are 0.08-1.9 nM and 6-45 nM for D 1 and D 2 receptors respectively). Also displays moderate affinity for the 5-HT 2A receptor (K i = 20 nM). Active in vivo .

storage

Room temperature

LE 300 Preparation Products And Raw materials

Raw materials

Preparation Products

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LE 300 Suppliers

China 27 Europe 1 Germany 2 Japan 1 Switzerland 2 United Kingdom 1 United States 7 USA 1 Global 42
Wako Pure Chemical Industries, Ltd.
Tel
--
Fax
--
Email
labchem-tec@wako-chem.co.jp
Country
Japan
ProdList
6819
Advantage
80

274694-98-3, LE 300Related Search:

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  • 7-METHYL-6,7,8,9,14,15-HEXAHYDRO-5H-BENZ[D]INDOLO[2,3-G]AZECINE
  • 6,7,8,9,14,15-HEXAHYDRO-7-METHYL-5H-INDOLO[3,2-F][3]BENZAZECINE
  • 6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f]benzazecine
  • LE 300
  • 5H-Indolo[3,2-f][3]benzazecine, 6,7,8,9,14,15-hexahydro-7-methyl-
  • 274694-98-3
  • Dopamine receptor