4-IODOPHENYL ISOCYANATE Property

Melting point:

44-48 °C(lit.)

Boiling point:

84°C 5mm

Density 

1.79±0.1 g/cm3(Predicted)

Flash point:

>230 °F

storage temp. 

2-8°C

form 

fused solid

color 

White

Sensitive 

Moisture & Light Sensitive

BRN 

2716151

Safety

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

22-26-36

RIDADR 

2811

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

II

HS Code 

2929100090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-IODOPHENYL ISOCYANATE Chemical Properties,Usage,Production

Uses

4-Iodophenyl isocyanate may be used in the preparation of:

• silicon-stereogenic silicon-bridged arylpyridinones
• N-(4-iodophenyl)cholesteryl-3-carbamate
• N-(4-iodophenyl)pregnenolone-3-carbamate

Preparation

To a solution of triphosgene (3.0 g, 10 mmol) and triethylamine (2.02 g, 20 mmol) in dry benzene (30 mL), a solution of 4-iodoaniline (4.3 g, 20 mmol) in dry benzene (15 mL) was added over 20 min. During the course of the addition, the temperature of the reaction mixture was increased from ambient to reflux temperature. After refluxing for 3 h, the reaction mixture was filtered. The filtrate was concentrated to obtain a residue, which was subjected to distillation under reduced pressure to afford a colorless liquid. Yield 2.21 g (45.2%).