R-tetrahydropapaverine HCl
- Product Name
- R-tetrahydropapaverine HCl
- CAS No.
- 54417-53-7
- Chemical Name
- R-tetrahydropapaverine HCl
- Synonyms
- R-BINAP;R-Tetrahydropapaverine;R-(+)-Tetrahydropapaverin;R-tetrahydropapaverine HC;R-tetrahydropapaverine HCl;R-TATRAHYDROPAPAVERINE HCL;Atracurium Besylate Impurity 7;D-(-)-Norlaudanosine hydrochloride;Cisatracurium Besilate Impurity 19;(R)-(-)-Norlaudanosine hydrochloride
- CBNumber
- CB5718052
- Molecular Formula
- C20H26ClNO4
- Formula Weight
- 379.88
- MOL File
- 54417-53-7.mol
R-tetrahydropapaverine HCl Property
- Boiling point:
- 475.8℃
- Density
- 1.32 at 22℃
- vapor pressure
- 0Pa at 25℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1/C20H25NO4.ClH/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16;/h5-6,10-12,16,21H,7-9H2,1-4H3;1H/t16-;/s3
- InChIKey
- VMPLLPIDRGXFTQ-LSQUZMQTNA-N
- SMILES
- C(C1C=CC(OC)=C(OC)C=1)[C@H]1NCCC2=CC(OC)=C(OC)C=C12.Cl |&1:11,r|
- LogP
- -0.63 at 25℃
- CAS DataBase Reference
- 54417-53-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B660
- Product name
- R-TetrahydropapaverineHCl
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FD132887
- Product name
- 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydroiodide
- Packaging
- 10g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FD132887
- Product name
- 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydroiodide
- Packaging
- 25g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- 47940
- Product name
- (R)-(-)-NorlaudanosineHCl
- Packaging
- 100mg
- Price
- $635
- Updated
- 2021/12/16
- Product number
- CD11107248
- Product name
- (R)-1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolinehydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
R-tetrahydropapaverine HCl Chemical Properties,Usage,Production
Application
R-tetrahydropapaverine HCl is a useful research chemical.
Synthesis
6429-04-5
54417-53-7
The general procedure for the synthesis of the target compound using 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride as raw material was as follows: 20 g of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride was dissolved in 400 mL of distilled water, and stirred until completely dissolved. Subsequently, ammonia was added to the solution to adjust the pH, and after observing that no white oily material precipitated, 400 mL of toluene was added and mixed with thorough stirring. The organic phase (toluene layer) and the aqueous phase were separated to ensure that there was no residual raw material in the aqueous phase. The organic phase was dried with anhydrous sodium sulfate to obtain 17.3 g of racemate. The racemate was dissolved in 173 mL of acetonitrile and heated to 70 °C. 3.93 g of the splitting agent N-acetyl-D-leucine was slowly added and the reaction was stirred for 20 minutes. Next, 0.522 g of the splitting agent N-acetyl-D-phenylalanine was added and the reaction was continued with stirring for 35 minutes. Upon completion of the reaction, it was slowly cooled to room temperature and subsequently stored in a refrigerator at 4°C for 24 hours to promote crystallization. Upon completion of crystallization, the solid product was collected by filtration. The product was converted to hydrochloride form, treated by adding appropriate amount of hydrochloric acid and dried to give 8.325 g of 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride in R-configuration. The total yield was 83.25% and the purity was 97.6%.
References
[1] Patent: CN107056700, 2017, A. Location in patent: Paragraph 0040-0043; 0046; 0058
R-tetrahydropapaverine HCl Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from R-tetrahydropapaverine HCl manufacturers
- Product
- R-tetrahydropapaverine HCl 54417-53-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1KG 10KG 100KG
- Release date
- 2025-05-22
- Product
- R-tetrahydropapaverine HCl 54417-53-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-06
- Product
- R-tetrahydropapaverine HCl 54417-53-7
- Price
- US $890.00/Kg
- Min. Order
- 1Kg
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-05-07