5-ISOXAZOLEMETHANOL
- Product Name
- 5-ISOXAZOLEMETHANOL
- CAS No.
- 98019-60-4
- Chemical Name
- 5-ISOXAZOLEMETHANOL
- Synonyms
- AKOS PAO-1429;5-ISOXAZOLEMETHANOL;Isoxazole-5-methanol;ISOXAZOL-5-YL-METHANOL;1,2-Oxazol-5-ylmethanol;5-(Hydroxymethyl)isoxazole;5-Isoxazolemethanol (6CI, 9CI, ACI)
- CBNumber
- CB5720857
- Molecular Formula
- C4H5NO2
- Formula Weight
- 99.09
- MOL File
- 98019-60-4.mol
5-ISOXAZOLEMETHANOL Property
- Boiling point:
- 115-125 °C(Press: 16 Torr)
- Density
- 1.250
- storage temp.
- 2-8°C
- pka
- 13.41±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-D0212
- Product name
- 5-(Hydroxymethyl)isoxazole
- Purity
- >97.0%
- Packaging
- 100mg
- Price
- $97
- Updated
- 2021/12/16
- Product number
- CS-D0212
- Product name
- 5-(Hydroxymethyl)isoxazole
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- CS-D0212
- Product name
- 5-(Hydroxymethyl)isoxazole
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $303
- Updated
- 2021/12/16
- Product number
- 6850AC
- Product name
- Isoxazol-5-ylmethanol
- Packaging
- 1g
- Price
- $458
- Updated
- 2021/12/16
- Product number
- 133365
- Product name
- 1,2-Oxazol-5-ylmethanol
- Purity
- 97%
- Packaging
- 1g
- Price
- $588
- Updated
- 2021/12/16
5-ISOXAZOLEMETHANOL Chemical Properties,Usage,Production
Synthesis
21169-71-1
98019-60-4
To a solution of isoxazole-5-carboxylic acid (1.0 g, 8.8 mmol) in tetrahydrofuran (THF, 10 mL) was slowly added borane-THF complex (26.4 mL, 1 M in THF, 26.4 mmol) at 0 °C. The reaction mixture was stirred at room temperature and the progress of the reaction was monitored by thin layer chromatography (TLC) until isoxazole-5-carboxylic acid was completely consumed. Upon completion of the reaction, ethanol (5 mL) was added slowly at 0 °C to quench the reaction. The reaction mixture was transferred to a dispensing funnel and partitioned with ethyl acetate and water. The organic phase was separated and the aqueous phase was back-extracted with ethyl acetate. All organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product isoxazol-5-ylmethanol. The crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (2:1, v/v) to give the pure isoxazol-5-ylmethanol (670 mg, 77.0% yield) as a light yellow oil. The product was analyzed by liquid chromatography-mass spectrometry (LC-MS) with a retention time of 0.329 min and a molecular ion peak (MH+) of 100.
References
[1] Patent: WO2014/143799, 2014, A2. Location in patent: Page/Page column 400; 401
[2] Patent: WO2013/30138, 2013, A1. Location in patent: Page/Page column 153; 15415
5-ISOXAZOLEMETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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