ChemicalBook > CAS DataBase List > Pentoxifylline

Pentoxifylline

Product Name
Pentoxifylline
CAS No.
6493-05-6
Chemical Name
Pentoxifylline
Synonyms
PTX;PENTOXYFYLLINE;TRENTAL;3,7-Dimethyl;PENTOXIFYLINE;Pentoxyfilline;3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione;bl191;BL 191;Rentylin
CBNumber
CB5721652
Molecular Formula
C13H18N4O3
Formula Weight
278.31
MOL File
6493-05-6.mol
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Pentoxifylline Property

Melting point:
98-100°C
Boiling point:
421.13°C (rough estimate)
Density 
1.1713 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
H2O: ≥43 mg/mL
form 
solid
pka
0.50±0.70(Predicted)
color 
white
λmax
276nm(lit.)
Merck 
14,7136
CAS DataBase Reference
6493-05-6(CAS DataBase Reference)
NIST Chemistry Reference
Pentoxifylline(6493-05-6)
EPA Substance Registry System
1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)- (6493-05-6)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
XH2475000
HS Code 
2939590000
Toxicity
LD50 orally in mice: 1385 mg/kg (Popendiker)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P1784
Product name
Pentoxifylline
Purity
solid
Packaging
10G
Price
$63.8
Updated
2024/03/01
Sigma-Aldrich
Product number
P1784
Product name
Pentoxifylline
Purity
solid
Packaging
100G
Price
$159.6
Updated
2024/03/01
Sigma-Aldrich
Product number
P1784
Product name
Pentoxifylline
Purity
solid
Packaging
250G
Price
$928
Updated
2024/03/01
Sigma-Aldrich
Product number
P0510000
Product name
Pentoxifylline
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
P0510000
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
1508901
Product name
Pentoxifylline
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200MG
Price
$436
Updated
2024/03/01
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Pentoxifylline Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Originator

Trental,Albert Roussel ,W. Germany ,1972

Uses

Pentoxifylline has been used:

  • used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
  • to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
  • to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour

Uses

Pentoxifylline is a methylxanthine phospho-diesterase inhibitor with favorable antiinflammatory effects and immunoregulatory properties.
A metabolite of Pentifylline. Methylxanthine derivative that improves blood flow by decreasing blood viscosity. Phosphodiesterase inhibitor. Inhibits the synthesis of tumor necrosis factor a (TNF-a).

Uses

Pentoxifylline can increase red blood cell deformability, reduce blood viscosity, and decrease platelet aggregation and thrombus formation. Pentoxifylline is an oral agent that improves perfusion of occluded vessels and is used to treat systemic vascular diseases. The retinal flow velocity in patients with RVO treated with pentoxifylline improved compared with placebo, but the study had a small number of patients (n = 8) and short follow-up (4 weeks), and no visual outcome data were reported.

Indications

Pentoxifylline at a dose of 400 mg three times a day after meals was reported to alleviate the symptoms in a small open trial.

Definition

ChEBI: Pentoxifylline is an oxopurine.

Manufacturing Process

A solution of 35.4 g of 1-bromohexanone-5 in 200 ml of ethanol was gradually mixed at the reflux temperature with vigorous stirring with 39.7 g of theobromine-sodium in 100 ml of water. After 3 hours reflux the unreacted theobromine was filtered off with suction, the filtrate was evaporated to dryness, the residue was dissolved in water and the solution was extracted with chloroform. The chloroform was distilled off and 1-(5'-oxohexyl)-3,7 Pentoxifylline dimethylxanthine was obtained as residue; after recrystallization from isopropanol, it melted at 102°C to 103°C (about 25% yield, calculated on the reacted theobromine).

brand name

Pentoxil (Upsher Smith); Trental (Sanofi Aventis).

Therapeutic Function

Vasodilator

Biological Activity

Phosphodiesterase inhibitor that blocks production of TNF- α and other cytokines. Displays antinociceptive activity.

Biochem/physiol Actions

Pentoxifylline?(PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline?is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (I?Bα) in serines 32 and 36.

Veterinary Drugs and Treatments

In horses, pentoxifylline has been used as adjunctive therapy for cutaneous, vasculitis, endotoxemia and for the treatment of navicular disease.
Pentoxifylline has been used in dogs to treat immune-mediated dermatologic conditions, enhance healing, and reduce inflammation caused by ulcerative dermatosis in Shelties and Collies and for other conditions where improved microcirculation may be of benefit. It is being investigated for adjunctive therapy for dilated cardiomyopathy in Doberman pinschers.
Pentoxifylline has been tried in conjunction with prednisolone to decrease vasculitis associated with FIP in cats.
Pentoxifylline’s major indications for humans include symptomatic treatment of peripheral vascular disease (e.g., intermittent claudication, sickle cell disease, Raynaud’s, etc.) and cerebrovascular diseases where blood flow may be impaired in the microvasculature.

Pentoxifylline Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Dihydropyran Theobromine 1-Bromo-3-chloropropane

Preparation Products

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View Lastest Price from Pentoxifylline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pentoxifylline 6493-05-6
Price
US $0.00/KG
Min. Order
25KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-09
Hebei Mojin Biotechnology Co., Ltd
Product
Pentoxifylline 6493-05-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-13
Shaanxi Dideu Medichem Co. Ltd
Product
Pentoxifylline 6493-05-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-11

6493-05-6, PentoxifyllineRelated Search:

Dehydroepiandrosterone Epiandrosterone acetate Tetrahydro-4H-pyran-4-one N,N-Dimethylformamide Purine Naringin dihydrochalcone Dimethyl fumarate Acetone oxime Dimethyl sulfate Poly(dimethylsiloxane) ETHANE Dimethyl ether Theobromine Dimethyl sulfoxide Dimethyl carbonate Pentoxifylline Impurity 8(Pentoxifylline EP Impurity H) 3,7-Dihydro-3,7-diMethyl-6-[(5-oxohexyl)oxy]-2H-purin-2-one 1,1'-[(5E)-5-Methyl-7-oxo-5-undecene-1,11-diyl] Bis

  • 3,7-DIHYDRO-3,7-DIMETHYL-1-(5-OXOHEXYL)-1H-PURINE-2,6-DIONE
  • PENTOXIFYLLINE
  • PENTOXYFYLLINE
  • PENTOXYIFYLLINE
  • PENTOXYPHYLINE
  • PTX
  • TRENTAL
  • 1-(5-Oxohexyl)-3,7-dimethylxanthine
  • bl191
  • Dimethyloxohexylxanthine
  • Durapental
  • oxpentifylline
  • Pentoxifyllin
  • Pentoxiphyllium
  • Pentoxyphylline
  • Rentylin
  • Theobromine, 1-(5-oxohexyl)-
  • Theobromine,1-(5-oxohexyl)-
  • Torental
  • Vazofirin
  • 1-(5-oxohexyl)-theobromin
  • 1-(5-Oxohexyl)theobromine
  • 1-(5-oxohexyl)-Theobromine
  • 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-
  • 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1h-purine-6-dione
  • 3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione
  • 3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
  • 3,7-Dimethyl-1-(5-oxohexyl)xanthine
  • [Oxo-5-hexyl]-1-dimethyl-37-dioxo-2,6-tetrahydro-1,2,3,6-purine
  • 3,7-Dimethyl-1-(5-oxohexyl)purine-2,6-dione
  • 3,9-Dimethyl-1-(5-oxohexyl)-2,3,6,9-tetrahydro-1H-purine-2,6-dione
  • 3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-pyrine-2,6-dione
  • Azupentat
  • BL 191
  • 3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental
  • 3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydropurine-2,6-dione
  • Pentoxifylline,99%
  • 3,7-Dimethyl
  • Pentoxyfilline
  • Pentoxifylline (200 mg)
  • 3,7-diMethyl-1-(5-oxohexyl)-1H-purine-2,6(3H,7H)-dione
  • PENTOXIFYLINE
  • C13H18N4O3 278.31
  • Pentoxyfyline Hydrochloride
  • 1-(5-Oxohexyl)-3,7-dimethyl-1,2,3,6-tetrahydro-7H-purine-2,6-dione
  • 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purin-2,6-dione
  • 3,9-dimethyl-1-(5-oxohexyl)purine-2,6-dione
  • PTX;OXPENTIFYLLINE
  • Pentoxifylline CRS
  • Pentoxifylline&gt
  • PentoxifyllineSolution,2000mg/L,4x1ml
  • Pentoxifylline USP/EP/BP
  • Pentoxifylline (P0510000)Q: What is Pentoxifylline (P0510000) Q: What is the CAS Number of Pentoxifylline (P0510000)
  • Pentoxifylline (1508901)
  • 5-ethyl-5-[(2RS)-4-methylpentan-2-yl]-1,3-diazinane-2,4,6-trione
  • Pentoxifylline, ≥ 98.0%
  • Pentoxifyl1ine
  • Oxpentifylline|||PTX|||BL-191