ChemicalBook > CAS DataBase List > Pentoxifylline

Pentoxifylline

Product Name
Pentoxifylline
CAS No.
6493-05-6
Chemical Name
Pentoxifylline
Synonyms
PTX;PENTOXYFYLLINE;TRENTAL;3,7-Dimethyl;PENTOXIFYLINE;Pentoxyfilline;3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione;bl191;BL 191;Rentylin
CBNumber
CB5721652
Molecular Formula
C13H18N4O3
Formula Weight
278.31
MOL File
6493-05-6.mol
More
Less

Pentoxifylline Property

Melting point:
98-100°C
Boiling point:
421.13°C (rough estimate)
Density 
1.1713 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
H2O: ≥43 mg/mL
form 
solid
pka
0.50±0.70(Predicted)
color 
white
λmax
276nm(lit.)
Merck 
14,7136
CAS DataBase Reference
6493-05-6(CAS DataBase Reference)
NIST Chemistry Reference
Pentoxifylline(6493-05-6)
EPA Substance Registry System
1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)- (6493-05-6)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
XH2475000
HS Code 
2939590000
Toxicity
LD50 orally in mice: 1385 mg/kg (Popendiker)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P1784
Product name
Pentoxifylline
Purity
solid
Packaging
10G
Price
$63.8
Updated
2024/03/01
Sigma-Aldrich
Product number
P1784
Product name
Pentoxifylline
Purity
solid
Packaging
100G
Price
$159.6
Updated
2024/03/01
Sigma-Aldrich
Product number
P1784
Product name
Pentoxifylline
Purity
solid
Packaging
250G
Price
$928
Updated
2024/03/01
Sigma-Aldrich
Product number
P0510000
Product name
Pentoxifylline
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
P0510000
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
1508901
Product name
Pentoxifylline
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200MG
Price
$436
Updated
2024/03/01
More
Less

Pentoxifylline Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Originator

Trental,Albert Roussel ,W. Germany ,1972

Uses

Pentoxifylline has been used:

  • used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
  • to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
  • to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour

Uses

Pentoxifylline is a methylxanthine phospho-diesterase inhibitor with favorable antiinflammatory effects and immunoregulatory properties.
A metabolite of Pentifylline. Methylxanthine derivative that improves blood flow by decreasing blood viscosity. Phosphodiesterase inhibitor. Inhibits the synthesis of tumor necrosis factor a (TNF-a).

Uses

Pentoxifylline can increase red blood cell deformability, reduce blood viscosity, and decrease platelet aggregation and thrombus formation. Pentoxifylline is an oral agent that improves perfusion of occluded vessels and is used to treat systemic vascular diseases. The retinal flow velocity in patients with RVO treated with pentoxifylline improved compared with placebo, but the study had a small number of patients (n = 8) and short follow-up (4 weeks), and no visual outcome data were reported.

Indications

Pentoxifylline at a dose of 400 mg three times a day after meals was reported to alleviate the symptoms in a small open trial.

Definition

ChEBI: Pentoxifylline is an oxopurine.

Manufacturing Process

A solution of 35.4 g of 1-bromohexanone-5 in 200 ml of ethanol was gradually mixed at the reflux temperature with vigorous stirring with 39.7 g of theobromine-sodium in 100 ml of water. After 3 hours reflux the unreacted theobromine was filtered off with suction, the filtrate was evaporated to dryness, the residue was dissolved in water and the solution was extracted with chloroform. The chloroform was distilled off and 1-(5'-oxohexyl)-3,7 Pentoxifylline dimethylxanthine was obtained as residue; after recrystallization from isopropanol, it melted at 102°C to 103°C (about 25% yield, calculated on the reacted theobromine).

brand name

Pentoxil (Upsher Smith); Trental (Sanofi Aventis).

Therapeutic Function

Vasodilator

Biological Activity

Phosphodiesterase inhibitor that blocks production of TNF- α and other cytokines. Displays antinociceptive activity.

Biochem/physiol Actions

Pentoxifylline?(PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline?is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (I?Bα) in serines 32 and 36.

Veterinary Drugs and Treatments

In horses, pentoxifylline has been used as adjunctive therapy for cutaneous, vasculitis, endotoxemia and for the treatment of navicular disease.
Pentoxifylline has been used in dogs to treat immune-mediated dermatologic conditions, enhance healing, and reduce inflammation caused by ulcerative dermatosis in Shelties and Collies and for other conditions where improved microcirculation may be of benefit. It is being investigated for adjunctive therapy for dilated cardiomyopathy in Doberman pinschers.
Pentoxifylline has been tried in conjunction with prednisolone to decrease vasculitis associated with FIP in cats.
Pentoxifylline’s major indications for humans include symptomatic treatment of peripheral vascular disease (e.g., intermittent claudication, sickle cell disease, Raynaud’s, etc.) and cerebrovascular diseases where blood flow may be impaired in the microvasculature.

Pentoxifylline Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Pentoxifylline Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19863
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38463
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
1091
Advantage
58
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
ACIC Fine Chemicals Inc.
Tel
--
Fax
--
Email
sales@acic.com
Country
United States
ProdList
492
Advantage
48
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
235
Advantage
68
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
212
Advantage
30
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
SynFine Research
Tel
--
Fax
--
Email
research@synfine.com
Country
United States
ProdList
1024
Advantage
68
Parchem Trading Ltd.
Tel
--
Fax
--
Email
info@parchem.com
Country
United States
ProdList
794
Advantage
76
Parchem Trading Ltd.
Tel
--
Fax
--
Email
info@par-chem.com
Country
United States
ProdList
740
Advantage
66
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
Kainic.com
Tel
--
Fax
--
Email
info@Kainic.com
Country
United States
ProdList
330
Advantage
38
EMD Biosciences, Inc.
Tel
--
Fax
--
Email
technical@calbiochem.com
Country
United States
ProdList
6529
Advantage
66
Aakash Chemicals and Dye-Stuffs, Inc.
Tel
--
Fax
--
Email
info@aakashchemicals.com
Country
United States
ProdList
1012
Advantage
54
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Crescent Chemical Co., Inc.
Tel
--
Fax
--
Email
sales@creschem.com
Country
United States
ProdList
4597
Advantage
68
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
A.G. Scientific, Inc.
Tel
--
Fax
--
Email
support@agscientific.com
Country
United States
ProdList
1066
Advantage
71
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
More
Less

View Lastest Price from Pentoxifylline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pentoxifylline 6493-05-6
Price
US $0.00/KG
Min. Order
25KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-09
Hebei Mojin Biotechnology Co., Ltd
Product
Pentoxifylline 6493-05-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-13
Shaanxi Dideu Medichem Co. Ltd
Product
Pentoxifylline 6493-05-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-11

6493-05-6, PentoxifyllineRelated Search:


  • 3,7-DIHYDRO-3,7-DIMETHYL-1-(5-OXOHEXYL)-1H-PURINE-2,6-DIONE
  • PENTOXIFYLLINE
  • PENTOXYFYLLINE
  • PENTOXYIFYLLINE
  • PENTOXYPHYLINE
  • PTX
  • TRENTAL
  • 1-(5-Oxohexyl)-3,7-dimethylxanthine
  • bl191
  • Dimethyloxohexylxanthine
  • Durapental
  • oxpentifylline
  • Pentoxifyllin
  • Pentoxiphyllium
  • Pentoxyphylline
  • Rentylin
  • Theobromine, 1-(5-oxohexyl)-
  • Theobromine,1-(5-oxohexyl)-
  • Torental
  • Vazofirin
  • 1-(5-oxohexyl)-theobromin
  • 1-(5-Oxohexyl)theobromine
  • 1-(5-oxohexyl)-Theobromine
  • 1H-Purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-
  • 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl)-1h-purine-6-dione
  • 3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione
  • 3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione
  • 3,7-Dimethyl-1-(5-oxohexyl)xanthine
  • [Oxo-5-hexyl]-1-dimethyl-37-dioxo-2,6-tetrahydro-1,2,3,6-purine
  • 3,7-Dimethyl-1-(5-oxohexyl)purine-2,6-dione
  • 3,9-Dimethyl-1-(5-oxohexyl)-2,3,6,9-tetrahydro-1H-purine-2,6-dione
  • 3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-pyrine-2,6-dione
  • Azupentat
  • BL 191
  • 3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental
  • 3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydropurine-2,6-dione
  • Pentoxifylline,99%
  • 3,7-Dimethyl
  • Pentoxyfilline
  • Pentoxifylline (200 mg)
  • 3,7-diMethyl-1-(5-oxohexyl)-1H-purine-2,6(3H,7H)-dione
  • PENTOXIFYLINE
  • C13H18N4O3 278.31
  • Pentoxyfyline Hydrochloride
  • 1-(5-Oxohexyl)-3,7-dimethyl-1,2,3,6-tetrahydro-7H-purine-2,6-dione
  • 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purin-2,6-dione
  • 3,9-dimethyl-1-(5-oxohexyl)purine-2,6-dione
  • PTX;OXPENTIFYLLINE
  • Pentoxifylline CRS
  • Pentoxifylline&gt
  • PentoxifyllineSolution,2000mg/L,4x1ml
  • Pentoxifylline USP/EP/BP
  • Pentoxifylline (P0510000)Q: What is Pentoxifylline (P0510000) Q: What is the CAS Number of Pentoxifylline (P0510000)
  • Pentoxifylline (1508901)
  • 5-ethyl-5-[(2RS)-4-methylpentan-2-yl]-1,3-diazinane-2,4,6-trione
  • Pentoxifylline, ≥ 98.0%
  • Pentoxifyl1ine
  • Oxpentifylline|||PTX|||BL-191