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Lomefloxacin hydrochloride

Product Name
Lomefloxacin hydrochloride
CAS No.
98079-52-8
Chemical Name
Lomefloxacin hydrochloride
Synonyms
LOMEFLOXACIN HCL;1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride;ny198;omefL;bareon;Okacin;Okacyn;Chimono;Uniquin;LoMflox
CBNumber
CB5723616
Molecular Formula
C17H20ClF2N3O3
Formula Weight
387.81
MOL File
98079-52-8.mol
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Lomefloxacin hydrochloride Property

Melting point:
290-3000C
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
1 M NaOH: soluble50mg/mL
form 
powder to crystal
color 
white to off-white
Merck 
14,5562
CAS DataBase Reference
98079-52-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
VB1997500
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L2906
Product name
Lomefloxacin hydrochloride
Packaging
1g
Price
$76.9
Updated
2024/03/01
Sigma-Aldrich
Product number
L2906
Product name
Lomefloxacin hydrochloride
Packaging
10g
Price
$461
Updated
2024/03/01
TCI Chemical
Product number
L0216
Product name
Lomefloxacin Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$95
Updated
2024/03/01
TCI Chemical
Product number
L0216
Product name
Lomefloxacin Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$277
Updated
2023/06/20
Cayman Chemical
Product number
28271
Product name
Lomefloxacin (hydrochloride)
Packaging
10g
Price
$116
Updated
2024/03/01
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Lomefloxacin hydrochloride Chemical Properties,Usage,Production

Description

Lomefloxacin is an orally bioavailable, broad-spectrum fluoroquinolone antibiotic. In vitro, it inhibits growth of N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, and M. morganii (MIC90s = 0.1, 0.39, 0.39, 0.39, 0.39, and 0.78 μg/ml, respectively). It also inhibits growth of S. aureus and methicillin-resistant S. aureus (MRSA; MIC90 = 3.13 μg/ml for both) and of H. influenzae and ampicillin-resistant H. influenzae (MIC90 = 0.1 μg/ml for both). In vivo, lomefloxacin inhibits the growth of P. mirabilis, E. coli, K. pneumoniae, and S. aureus (ED50s = 1.39, 1.45, 1.78, and 6.66 mg/kg, respectively) in mouse models of systemic infection. It inhibits bacterial DNA gyrase, thereby inhibiting DNA synthesis and bacterial growth. Formulations containing lomefloxacin have been used in the treatment of bronchitis and urinary tract bacterial infections.

Description

Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment.

Chemical Properties

White powder with no smell, bitter taste

Originator

Foxil,Sarabhai Chemicals,India

Uses

Fluorinated quinolone antibacterial. DNA gyrase antagonist

Definition

ChEBI: The hydrochloride salt of lomefloxacin. It is administered by mouth to treat bacterial infections including bronchitis and urinary tract infections. It is also used topically as eye drops for the treatment of bacterial conjunctivitis, and as ear drops for he treatment of otitis externa and otitis media.

Manufacturing Process

A mixture of 1.00 g of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3- carboxylic acid, 1.10 g of 2-methylpiperazine and 10 ml of pyridine was heated for 15 minutes under reflux. The reaction mixture was evaporated and methanol was added to the residue. The precipitate was filtered and recrystallized from ethanol to give 0.36 g of the 1-ethyl-6,8-difluoro-1,4- dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid as colorless needles, melting point 239.0-240.5°C.
By the usual manner the hydrochloride was prepared and recrystallized from water as colorless needles, melting point 290-300°C (decomp.).

brand name

Maxaquin (Pharmacia).

Therapeutic Function

Antibacterial

References

Wadworth, A. N., and K. L. Goa. "Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. " Drugs 42.6(1991): 1018-60.
Symonds, W. T., and D. E. Nix. "Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials." Clin Pharm 11.9(1992): 753-66.

Lomefloxacin hydrochloride Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 2-Methylpiperazine 1,2,3-Trifluoro-4-nitrobenzene Bromoethane Pyridine

Preparation Products

Lomefloxacin
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Lomefloxacin hydrochloride Suppliers

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View Lastest Price from Lomefloxacin hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Lomefloxacin hydrochloride 98079-52-8
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99.5~101.0%
Supply Ability
5ton/month
Release date
2021-07-03
Henan Fengda Chemical Co., Ltd
Product
Lomefloxacin hydrochloride 98079-52-8
Price
US $32.00-1.30/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-15
Dideu Industries Group Limited
Product
Lomefloxacin hydrochloride 98079-52-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-19

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