Lomefloxacin hydrochloride

Product Name: Lomefloxacin hydrochloride
CAS No.: 98079-52-8
Chemical Name: Lomefloxacin hydrochloride
Synonyms: LOMEFLOXACIN HCL;1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid hydrochloride;ny198;omefL;bareon;Okacin;Okacyn;Chimono;Uniquin;LoMflox
CBNumber: CB5723616
Molecular Formula: C17H20ClF2N3O3
Formula Weight: 387.81
MOL File: 98079-52-8.mol

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Lomefloxacin hydrochloride Property

Melting point:: 290-3000C
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: 1 M NaOH: soluble50mg/mL
form: powder to crystal
color: white to off-white
biological source: synthetic
Merck: 14,5562
CAS DataBase Reference: 98079-52-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: VB1997500
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L2906
Product name: Lomefloxacin hydrochloride
Packaging: 1g
Price: $76.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: L2906
Product name: Lomefloxacin hydrochloride
Packaging: 10g
Price: $461
Updated: 2024/03/01

TCI Chemical

Product number: L0216
Product name: Lomefloxacin Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $95
Updated: 2024/03/01

TCI Chemical

Product number: L0216
Product name: Lomefloxacin Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $277
Updated: 2023/06/20

Cayman Chemical

Product number: 28271
Product name: Lomefloxacin (hydrochloride)
Packaging: 10g
Price: $116
Updated: 2024/03/01

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Lomefloxacin hydrochloride Chemical Properties,Usage,Production

Description

Lomefloxacin is an orally bioavailable, broad-spectrum fluoroquinolone antibiotic. In vitro, it inhibits growth of N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, and M. morganii (MIC₉₀s = 0.1, 0.39, 0.39, 0.39, 0.39, and 0.78 μg/ml, respectively). It also inhibits growth of S. aureus and methicillin-resistant S. aureus (MRSA; MIC₉₀ = 3.13 μg/ml for both) and of H. influenzae and ampicillin-resistant H. influenzae (MIC₉₀ = 0.1 μg/ml for both). In vivo, lomefloxacin inhibits the growth of P. mirabilis, E. coli, K. pneumoniae, and S. aureus (ED₅₀s = 1.39, 1.45, 1.78, and 6.66 mg/kg, respectively) in mouse models of systemic infection. It inhibits bacterial DNA gyrase, thereby inhibiting DNA synthesis and bacterial growth. Formulations containing lomefloxacin have been used in the treatment of bronchitis and urinary tract bacterial infections.

Description

Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment.

Chemical Properties

White powder with no smell, bitter taste

Originator

Foxil,Sarabhai Chemicals,India

Uses

Fluorinated quinolone antibacterial. DNA gyrase antagonist

Definition

ChEBI: The hydrochloride salt of lomefloxacin. It is administered by mouth to treat bacterial infections including bronchitis and urinary tract infections. It is also used topically as eye drops for the treatment of bacterial conjunctivitis, and as ear drops for he treatment of otitis externa and otitis media.

Manufacturing Process

A mixture of 1.00 g of 1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3- carboxylic acid, 1.10 g of 2-methylpiperazine and 10 ml of pyridine was heated for 15 minutes under reflux. The reaction mixture was evaporated and methanol was added to the residue. The precipitate was filtered and recrystallized from ethanol to give 0.36 g of the 1-ethyl-6,8-difluoro-1,4- dihydro-7-(3-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid as colorless needles, melting point 239.0-240.5°C.
By the usual manner the hydrochloride was prepared and recrystallized from water as colorless needles, melting point 290-300°C (decomp.).

brand name

Maxaquin (Pharmacia).

Therapeutic Function

Antibacterial

References

Wadworth, A. N., and K. L. Goa. "Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. " Drugs 42.6(1991): 1018-60.
Symonds, W. T., and D. E. Nix. "Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials." Clin Pharm 11.9(1992): 753-66.

Lomefloxacin hydrochloride Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 2-Methylpiperazine 1,2,3-Trifluoro-4-nitrobenzene Bromoethane Pyridine

Preparation Products

Lomefloxacin

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View Lastest Price from Lomefloxacin hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Lomefloxacin hydrochloride 98079-52-8
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 99.5~101.0%
Supply Ability: 5ton/month
Release date: 2021-07-03

Henan Fengda Chemical Co., Ltd

Product: Lomefloxacin hydrochloride 98079-52-8
Price: US $32.00-1.30/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-15

Dideu Industries Group Limited

Product: Lomefloxacin hydrochloride 98079-52-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-19

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Lomefloxacin·HCl≥ 99% (HPLC)

omefL

Lomefloxacin Hydrochloride Standard

LomefloxacinHydrochloride&gt

Lomefloxacin hydrochloride USP/EP/BP

Lomefloxacin HydrochlorideQ: What is Lomefloxacin Hydrochloride Q: What is the CAS Number of Lomefloxacin Hydrochloride Q: What is the storage condition of Lomefloxacin Hydrochloride Q: What are the applications of Lomefloxacin Hydrochloride

Lomefloxacin Hydrochloride (LMF), 98.5%

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98079-52-8

C17H19F2N3O3HCl

C17H20ClF2N3O3

C17H19F2N3O3ClH

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