Swertisin
- Product Name
- Swertisin
- CAS No.
- 6991-10-2
- Chemical Name
- Swertisin
- Synonyms
- Tris(1;SWERTISIN;SWERTISIN(P);Swertisin-RM;Swertia flavin;Genkwanin 6-C-Glucoside;3-dichloroisopropyl)phosphate;APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER;4',5-Dihydroxy-7-methoxy-6-β-D-glucopyranosylflavone;Swertisin, 98%, from Swertia diluta (Turcz.) Benth. & Hook.f.
- CBNumber
- CB5724709
- Molecular Formula
- C22H22O10
- Formula Weight
- 446.4
- MOL File
- 6991-10-2.mol
Swertisin Property
- Melting point:
- 245-246℃
- Boiling point:
- 716.6±60.0 °C(Predicted)
- Density
- 1.583±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO; sparingly soluble in methanol;
- pka
- 5.76±0.40(Predicted)
- form
- powder
- color
- White-pale yellow
- Water Solubility
- slightly soluble in water
N-Bromosuccinimide Price
- Product number
- PHL83912
- Product name
- Swertisin
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $377.4
- Updated
- 2024/03/01
- Product number
- 301021
- Product name
- Swertisin
- Packaging
- 10mg
- Price
- $581
- Updated
- 2021/12/16
- Product number
- orb259583
- Product name
- Swertisin
- Purity
- 98%
- Packaging
- 5mg
- Price
- $596.7
- Updated
- 2021/12/16
- Product number
- CS-0019497
- Product name
- Swertisin
- Packaging
- 5mg
- Price
- $686
- Updated
- 2021/12/16
- Product number
- FS74200
- Product name
- Swertisin
- Packaging
- 10mg
- Price
- $510
- Updated
- 2021/12/16
Swertisin Chemical Properties,Usage,Production
Chemical Properties
Swertisin is a flavonoid compound that appears as a light yellow powder or crystalline powder at room temperature. Its chemical formula is C22H22O10, with a molecular weight of 446. it is soluble in organic solvents such as methanol and dimethyl sulfoxide. It has antioxidant,anti-diabetic, anti-depressant, anti-inflammatory, anti-viral, and anti-radiation pharmacological effects.
Definition
ChEBI: Swertisin is a flavone C-glycoside that is 7-O-methylapigenin in which the hydrogen at position 6 has been replaced by a beta-D-glucosyl residue. It has a role as a plant metabolite, an adenosine A1 receptor antagonist, an anti-inflammatory agent, an antioxidant and a hypoglycemic agent. It is a flavone C-glycoside, a monosaccharide derivative, a polyphenol, a monomethoxyflavone and a dihydroxyflavone. It is functionally related to an apigenin.
Biological Activity
Swertisin is a flavonoid C-glycoside that has been found in Swertia japonica and has diverse biological activities. It inhibits sodium-glucose cotransporter 2 (SGLT2) in HEK293 cells when used at a concentration of 7.5 μg/ml and is an adenosine A1 receptor antagonist (IC50 = 137 μM). Swertisin (0.2-5 μM) inhibits hepatitis B virus (HBV) replication in HepG2 2.2.15 cells. It decreases blood glucose levels in a mouse model of diabetes induced by streptozotocin (Item No. 13104), as well as prevents scopolamine-induced increases in escape latency in the Morris water maze in mice.
References
[1] GURPRIT BHARDWAJ . Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapy[J]. Archives of biochemistry and biophysics, 2021, 710: Article 108995. DOI:10.1016/j.abb.2021.108995.
[2] K. PATEL D. P. Biological importance and therapeutic benefit of swertisin: An overview of medicinal importance and pharmacological activities[J]. Current Bioactive Compounds, 2022. DOI:10.2174/1573407218666220801113334.
[3] HONG-YAN XU . Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim[J]. Journal of ethnopharmacology, 2020, 257: Article 112787. DOI:10.1016/j.jep.2020.112787.
Swertisin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Swertisin manufacturers
- Product
- Swertisin 6991-10-2
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-24
- Product
- APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER 6991-10-2
- Price
- US $8.00/KG
- Min. Order
- 1g
- Purity
- ＞98% HPLC
- Supply Ability
- kg--ton
- Release date
- 2020-02-20