ChemicalBook > CAS DataBase List > TELMISARTAN-D3

TELMISARTAN-D3

Product Name
TELMISARTAN-D3
CAS No.
1189889-44-8
Chemical Name
TELMISARTAN-D3
Synonyms
Pritor-d3;BIBR 277-d3;Micardis-d3;BIBR 277SE-d3;TELMISARTAN-D3;D3-Telmisartan;Telmisartan-d3 in methanol;4'-[(1,4'-DiMethyl-2'-propyl[2,6'-bi-H-benziMidazol]-1'-yl)Methyl][1,1'-biphenyl]-2-carboxylic Acid-d3;4'-[[4-Methyl-6-(1-Methyl-2-benziMidazolyl)-2-propyl-1-benziMidazolyl] Methyl]-2-biphenylcarboxylic Acid-d3;4'-({4-methyl-6-[1-(2H?)methyl-1H-1,3-benzodiazol-2-yl]-2-propyl-1H-1,3-benzodiazol-1-yl}methyl)-[1,1'-biphenyl]-2-carboxylic acid
CBNumber
CB5730269
Molecular Formula
C33H27D3N4O2
Formula Weight
517.64
MOL File
Mol file
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TELMISARTAN-D3 Property

Melting point:
262-265°C
storage temp. 
-20°C Freezer, Under Inert Atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
color 
White to Beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
22568
Product name
Telmisartan-d3
Purity
≥99% deuterated forms (d1-d3)
Packaging
500μg
Price
$178
Updated
2024/03/01
Cayman Chemical
Product number
22568
Product name
Telmisartan-d3
Purity
≥99% deuterated forms (d1-d3)
Packaging
1mg
Price
$336
Updated
2024/03/01
TRC
Product number
T017002
Product name
Telmisartan-d3
Packaging
1mg
Price
$175
Updated
2021/12/16
Usbiological
Product number
T2240-01
Product name
Telmisartan-d3
Packaging
1mg
Price
$446
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
D13650
Product name
Telmisartan-d3
Packaging
1mg
Price
$390
Updated
2021/12/16
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TELMISARTAN-D3 Chemical Properties,Usage,Production

Description

Telmisartan-d3 is intended for use as an internal standard for the quantification of telmisartan by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT1 (Ki = 3.7 nM). It also acts as a partial agonist of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to 25-30% of that produced by the full agonist rosiglitazone (; EC50 = 4.5 μM). Through these actions, telmisartan potently reduces blood pressure in various animal models of hypertension, diminishing cardiac hypertrophy, cardiovascular and renal risk, and glomerulosclerosis.

Chemical Properties

Off-White Crystalline Solid

Uses

Labelled Telmisartan, an angiotensin II receptor antagonist

Uses

TelMisartan-d3 can be intended for use as an internal standard for the quantification of Telmisartan by GC- or LC-mass spectrometry.

Uses

TelMisartan-d3 is an angiotensin II receptor antagonist.

References

[1] W. WIENEN. Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277[J]. British Journal of Pharmacology, 1993, 110 1: 245-252. DOI: 10.1111/j.1476-5381.1993.tb13800.x
[2] STEPHEN C BENSON. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity.[J]. Hypertension, 2004, 43 5: 993-1002. DOI: 10.1161/01.hyp.0000123072.34629.57
[3] ARONOW W S. Telmisartan[J]. Drugs, 2012, 56 1: 1045. DOI: 10.2165/00003495-199856060-00009
[4] JUGDUTT B I. Clinical effectiveness of telmisartan alone or in combination therapy for controlling blood pressure and vascular risk in the elderly.[J]. Clinical Interventions in Aging, 2010, 5: 403-416. DOI: 10.2147/cia.s6709
[5] ROLAND E SCHMIEDER  Matthew R W  George Bakris. Telmisartan in incipient and overt diabetic renal disease.[J]. Journal of Nephrology, 2011, 24 3: 263-273. DOI: 10.5301/jn.2011.6416

TELMISARTAN-D3 Preparation Products And Raw materials

Raw materials

Preparation Products

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TELMISARTAN-D3 Suppliers

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1189889-44-8, TELMISARTAN-D3Related Search:

tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate 6-Des(1-Methyl-2-benziMidazolyl)-6-carboxy TelMisartan 2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole Telmisartan Related Compound B (15 mg) (4'-[(1,7'-dimethyl-2'-propyl-1H,1'H-2,5'-bibenzo[d]imidazol-1'-yl)methyl]biphenyl-2-carboxylic acid) propyl[2,6'-bi-1H-benzimidazol]-1'-yl]methyl]- TelMisartan AMide Telmisartan tert-Butyl Ester TelMisartan-13CD3 Telmisartan

  • TELMISARTAN-D3
  • 4'-[(1,4'-DiMethyl-2'-propyl[2,6'-bi-H-benziMidazol]-1'-yl)Methyl][1,1'-biphenyl]-2-carboxylic Acid-d3
  • 4'-[[4-Methyl-6-(1-Methyl-2-benziMidazolyl)-2-propyl-1-benziMidazolyl] Methyl]-2-biphenylcarboxylic Acid-d3
  • BIBR 277-d3
  • BIBR 277SE-d3
  • Micardis-d3
  • Pritor-d3
  • Telmisartan D3Q: What is Telmisartan D3 Q: What is the CAS Number of Telmisartan D3 Q: What is the storage condition of Telmisartan D3 Q: What are the applications of Telmisartan D3
  • 4'-({4-methyl-6-[1-(2H?)methyl-1H-1,3-benzodiazol-2-yl]-2-propyl-1H-1,3-benzodiazol-1-yl}methyl)-[1,1'-biphenyl]-2-carboxylic acid
  • Telmisartan-d3 in methanol
  • D3-Telmisartan
  • 1189889-44-8
  • C33H27D3N4O2
  • Intermediates & Fine Chemicals
  • Metabolites
  • Pharmaceuticals
  • Various Metabolites and Impurities
  • Aromatics
  • Heterocycles
  • Isotope Labelled Compounds