tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
- Product Name
- tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
- CAS No.
- 114772-40-6
- Chemical Name
- tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate
- Synonyms
- tert-Butyl 4'-(broMoMethyl)-[1,1'-biphenyl]-2-carboxylate;Tert-Buthyl;Telmisartan EP Impurity H;Telmisatran EP impurity H;Telmisartan Impurity H（EP）;2-Bromo-7-methoxybenzoicacid;2-Boc-4'-(broMoMethyl)biphenyl;Telmisartan Bromo t-Butyl Ester;1,1-Dimethylethyl Esterbiphenyl;2'-(tert-Butoxylcarbonyl)bipheny
- CBNumber
- CB7395215
- Molecular Formula
- C18H19BrO2
- Formula Weight
- 347.25
- MOL File
- 114772-40-6.mol
tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate Property
- Melting point:
- 108-110°C
- Boiling point:
- 437.0±38.0 °C(Predicted)
- Density
- 1.278±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Soluble in chloroform, ethyl acetate, and DMSO.
- form
- Solid
- color
- White to Pale Yellow
- CAS DataBase Reference
- 114772-40-6(CAS DataBase Reference)
Safety
- Risk Statements
- 43-53
- Safety Statements
- 22-24-37-61
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B685385
- Product name
- 4’-(Bromomethyl)biphenyl-2-carboxylicAcidtert-ButylEster
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- B685385
- Product name
- 4’-(Bromomethyl)biphenyl-2-carboxylicAcidtert-ButylEster
- Packaging
- 5g
- Price
- $255
- Updated
- 2021/12/16
- Product number
- FB140353
- Product name
- tert-Butyl 4'-(bromomethyl)-[1,1'-biphenyl]-2-carboxylate
- Packaging
- 2g
- Price
- $51
- Updated
- 2021/12/16
- Product number
- 090158
- Product name
- 2-Boc-4'-(Bromomethyl)biphenyl
- Purity
- 97%
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- 4128CR
- Product name
- Tert-butyl4'-(bromomethyl)biphenyl-2-carboxylate
- Packaging
- 5g
- Price
- $96
- Updated
- 2021/12/16
tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Solid
Uses
1,1-Dimethylethyl Esterbiphenyl is used in the preparation of angiotensin II receptor antagonists.
Uses
tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate is a biphenyl derivative used in the preparation of angiotensin II receptor antagonists. T017000
Synthesis
114772-36-0
114772-40-6
The general procedure for the synthesis of tert-butyl 4'-bromomethylbiphenyl-2-carboxylate from tert-butyl 4'-methyl-[1,1'-biphenyl]-2-carboxylate was as follows: in a 1200-liter enameled stirring apparatus, 268.0 kg of tert-butyl 4'-methyl-[1,1'-biphenyl]-2-carboxylate, 157.3 kg of N-bromosuccinimide (DDH), 1.6 kg of azo diisobutyronitrile (AIBN), and 572 liters of methyl acetate. The mixture was heated to 60 °C until the solution became almost colorless. Subsequently, 458 liters of solvent were distilled at atmospheric pressure, followed by the addition of 530 liters of isopropanol, 148 liters of water and 16.4 kg of anhydrous sodium acetate. The resulting mixture was cooled to 15 °C to 25 °C and stirring was continued for 1 hour. The precipitated product was separated by centrifugation, washed with a mixture of 530 liters of acetone and 148 liters of water and finally dried. 295 kg of tert-butyl 4'-bromomethylbiphenyl-2-carboxylate was obtained in a yield of 85% of the theoretical value.
References
[1] Patent: US2002/95042, 2002, A1
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 7, p. 897 - 906
[3] Patent: US2002/95042, 2002, A1
[4] Patent: US2002/95042, 2002, A1
[5] Patent: WO2013/78237, 2013, A1. Location in patent: Page/Page column 78
tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate Preparation Products And Raw materials
Raw materials
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View Lastest Price from tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate manufacturers
- Product
- tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate 114772-40-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-25
- Product
- 4'-Bromomethyl Biphenyl-2-Carboxylic Acid tert-butyl ester 114772-40-6
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-01
- Product
- tert-Butyl 4'-(bromomethyl)biphenyl-2-carboxylate 114772-40-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-25