ChemicalBook > CAS DataBase List > 2'-C-Methylcytidine

2'-C-Methylcytidine

Product Name
2'-C-Methylcytidine
CAS No.
20724-73-6
Chemical Name
2'-C-Methylcytidine
Synonyms
NM-107;CS-2055;-C-Methylcytidine;2''-METHYLCYTIDINE;2'-C-METHYLCYTIDINE;2’-C-Methyl cytidine;2'-CMethyl-D-cytidine;2’-β-C-Methylcytidine;Cytidine, 2'-C-methyl-;2’-b-C-Methyl cytidine
CBNumber
CB5732016
Molecular Formula
C10H15N3O5
Formula Weight
257.24
MOL File
20724-73-6.mol
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2'-C-Methylcytidine Property

Melting point:
243-245°C
Boiling point:
523.9±60.0 °C(Predicted)
Density 
1.72±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
H2O: >20mg/mL
pka
13.53±0.70(Predicted)
form 
powder
color 
white to off-white
InChIKey
PPUDLEUZKVJXSZ-VPCXQMTMSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M4949
Product name
2’-C-Methylcytidine
Purity
≥95% (HPLC), powder
Packaging
5mg
Price
$97.9
Updated
2024/03/01
Sigma-Aldrich
Product number
M4949
Product name
2’-C-Methylcytidine
Purity
≥95% (HPLC), powder
Packaging
25mg
Price
$388
Updated
2024/03/01
Cayman Chemical
Product number
22887
Product name
2'-C-Methylcytidine
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
22887
Product name
2'-C-Methylcytidine
Purity
≥98%
Packaging
10mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
22887
Product name
2'-C-Methylcytidine
Purity
≥98%
Packaging
25mg
Price
$336
Updated
2024/03/01
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2'-C-Methylcytidine Chemical Properties,Usage,Production

Description

2''-C-Methylcytidine (2CMC) is a ribonucleoside with broad-spectrum antiviral activity. It reduces the number of viral plaques in BHK-21 cells infected with dengue type 2, reovirus type 1, West Nile, and yellow fever RNA viruses with EC50 values of 95, 26, 80, and 75 μM, respectively. 2CMC inhibits hepatitis C virus (HCV) replication (EC50 = 2.2 μM in a replicon assay) and protects MDBK cells from infection with bovine virus diarrhea virus (BVDV; EC50 = 2.2 μM) and human coronavirus (HCoV; EC50 = 90 μM). It also reduces infectious virus yield in BHK-21 cells infected with foot-and-mouth disease virus (FMDV; EC50 = 6.4 μM) and swine vesicular disease virus (SVDV; EC50 = 45.2 μM). In vivo, 2CMC reduces viral shedding to undetectable levels in a mouse model of persistent norovirus infection.

Chemical Properties

White to Off-White Powder

Uses

2’-C-Methyl Cytidine (cas# 20724-73-6) is a compound useful in organic synthesis.

Biochem/physiol Actions

2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase. 2′-C-Methylcytidine was the first nucleoside NS5B inhibitor that showed clinical efficacy. 2′-C-Methylcytidine was found to be effective against the 17D vaccine strain of yellow fever virus YFV in cell culture.

2'-C-Methylcytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2'-C-Methylcytidine Suppliers

Brazil 1 Canada 1 China 86 Germany 1 India 3 United Kingdom 3 United States 15 Global 110
Chongqing Chemieliva Pharmaceutical Co., Ltd.
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View Lastest Price from 2'-C-Methylcytidine manufacturers

NewCan Biotech Limited
Product
2'-C-methylCytidine 20724-73-6
Price
US $0.00-0.00/g
Min. Order
1g
Purity
98%
Supply Ability
100g
Release date
2024-06-03
Career Henan Chemical Co
Product
2'-C-Methylcytidine 20724-73-6
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-08-05

20724-73-6, 2'-C-MethylcytidineRelated Search:

Cytidine 5’-monophosphate 5-METHYLCYTOSINE Cytidine Cytosine 5-Fluorocytidine Fluorocytosine Cytidine-5'-triphosphate disodium salt dihydrate 5-Azacytidine Cytarabine 2'-C-Methylguanosine 2'-C-Methyladenosine 2'-METHYLCYTIDINE-5'-TRIPHOSPHATE, DIAMMONIUM SALT Valopicitabine 2'-METHYLCYTIDINE-5'-MONOPHOSPHATE, DIAMMONIUM SALT 2',3',5'-Tri-O-benzoyl-2'-C-methyl-D-cytidine 2'-C-Methylcytidine

  • 2'-C-METHYLCYTIDINE
  • 2'-CMethyl-D-cytidine
  • 2''-METHYLCYTIDINE
  • 1-(2-C-Methyl-β-D-ribofuranosyl)cytosine
  • NM-107
  • 2'-C-Methyl-1-β-D-ribofuranosylcytosine
  • -C-Methylcytidine
  • 2'-C-METHYLCYTIDINE;NM-107;VALOPICITABINE
  • CS-2055
  • 4-AMINO-1-[3,4-DIHYDROXY-5-(HYDROXYMETHYL)-3-METHYLOXOLAN-2-YL]PYRIMIDIN-2-ONE
  • Cytidine, 2'-C-methyl-
  • 2’-C-Methyl cytidine, 2’-C-Methyl-1-β-D-ribofuranosyl cytosine
  • 2’-β-C-Methylcytidine
  • 2'-C-Methylcytidine USP/EP/BP
  • 4-Amino-1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidin-2(1H)-one
  • 2’-b-C-Methyl cytidine NM107, HCV drug
  • 2’-b-C-Methyl cytidine
  • 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one
  • NM 107,inhibit,Inhibitor,HCV,Hepatitis C virus,NM107
  • 2’-C-Methyl cytidine
  • 2’-b-C-Methyl cytidine
  • 20724-73-6
  • C10H15N3O5
  • Bases & Related Reagents
  • Nucleotides