2-((4-Chlorophenyl)acetyl)benzoic acid
- Product Name
- 2-((4-Chlorophenyl)acetyl)benzoic acid
- CAS No.
- 53242-76-5
- Chemical Name
- 2-((4-Chlorophenyl)acetyl)benzoic acid
- Synonyms
- 2-[2-(4-chlor;Einecs 258-444-8;AZELASTINE EP IMP C;Azelastine Impurity C;Azelastine EP IMpurity C;Azelastine HCl EP Impurity C;Chlorophenylacetylbenzoic acid;2-(p-Chlorphenacetyl)-Benzoesaeure;2-(4-CHLOROPHENYLACETO)BENZOIC ACID;2-[(4-Chlorophenyl)acetyl]benzoic A
- CBNumber
- CB5735002
- Molecular Formula
- C15H11ClO3
- Formula Weight
- 274.7
- MOL File
- 53242-76-5.mol
2-((4-Chlorophenyl)acetyl)benzoic acid Property
- Melting point:
- 137-141°C
- Boiling point:
- 456.8±30.0 °C(Predicted)
- Density
- 1.332±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.36±0.36(Predicted)
- form
- Solid
- color
- White to Off-White
- InChI
- InChI=1S/C15H11ClO3/c16-11-7-5-10(6-8-11)9-14(17)12-3-1-2-4-13(12)15(18)19/h1-8H,9H2,(H,18,19)
- InChIKey
- BDSINYHJZLINDJ-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=CC=C1C(CC1=CC=C(Cl)C=C1)=O
- CAS DataBase Reference
- 53242-76-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FC151136
- Product name
- 2-(4-Chlorophenyl-acetyl)benzoicacid
- Packaging
- 5G
- Price
- $40
- Updated
- 2021/12/16
- Product number
- J10486
- Product name
- AzelastineImpurityC
- Packaging
- 100mg
- Price
- $48
- Updated
- 2021/12/16
- Product number
- FC151136
- Product name
- 2-(4-Chlorophenyl-acetyl)benzoicacid
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC151136
- Product name
- 2-(4-Chlorophenyl-acetyl)benzoicacid
- Packaging
- 25g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- J10486
- Product name
- AzelastineImpurityC
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
2-((4-Chlorophenyl)acetyl)benzoic acid Chemical Properties,Usage,Production
Uses
2-[(4-Chlorophenyl)acetyl]benzoic Acid is an impurity of Azelastine (A808250).
Uses
2-[(4-Chlorophenyl)acetyl]benzoic Acid (Azelastine EP Impurity C) is an impurity of Azelastine (A808250).
Synthesis
1878-66-6
85-44-9
53242-76-5
P-chlorobenzene acetic acid, phthalic anhydride and freshly melted sodium acetate were added to the reaction kettle in a certain ratio. The reaction was rapidly heated to about 250 °C and continuously stirred at 240-250 °C for 3 h. The water generated during the reaction was discharged through the tail of the reactor. Subsequently, the reaction mixture was transferred to an open heat-resistant vessel and continued to be heated. After the reaction mixture cooled, cold anhydrous ethanol was added. The mixture was heated until the solid was as dissolved as possible, then cooled and filtered. The filter cake was washed with anhydrous ethanol, filtered again and dried. The dried solid was dissolved in aqueous sodium hydroxide solution and stirred under reflux conditions for 4 hours. After completion of the reaction, the mixture was cooled, diluted with water and acidified with 20% hydrochloric acid to pH 2-3. After stirring and cooling, a solid oily precipitate was formed. The precipitate was filtered and dried to give the crude product. The crude product was evaporated from acetone by dissolving in acetone and filtering out the insoluble material. The residue was recrystallized with ethyl acetate to give the final target product 2-(4-chlorophenylacetyl)benzoic acid. The product had a melting point of 142-144 °C and a yield of 80%.
References
[1] Patent: CN108003005, 2018, A. Location in patent: Paragraph 0010; 0011; 0012
2-((4-Chlorophenyl)acetyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-((4-Chlorophenyl)acetyl)benzoic acid Suppliers
- Tel
- 15005516438
- Fax
- 15005516438
- sales1@qiushipharm.com
- Country
- China
- ProdList
- 82
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0311-89250318 031166536426
- Fax
- 4000311741
- master@sjzsdyn.com
- Country
- China
- ProdList
- 2809
- Advantage
- 65
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 010-82954736 13391601435
- sales@isomersyn.com
- Country
- China
- ProdList
- 3295
- Advantage
- 57
- Tel
- 0571-82693216
- Fax
- +86-571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 6387
- Advantage
- 52
- Tel
- 0755-4000505016 13380397412
- Fax
- 0755 28094224
- 3001272453@qq.com
- Country
- China
- ProdList
- 5158
- Advantage
- 50
View Lastest Price from 2-((4-Chlorophenyl)acetyl)benzoic acid manufacturers
- Product
- 2-((4-Chlorophenyl)acetyl)benzoic acid 53242-76-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-01
- Product
- N-(2,3-epoxypropyl)phthalimide 53242-76-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- N-(2,3-epoxypropyl)phthalimide 53242-76-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09