F16

Product Name: F16
CAS No.: 36098-33-6
Chemical Name: F16
Synonyms: F16;F16 (F-16;Compound F16);F-16;COMPOUND F16;F16/Cell proliferation inhibitor (F16);4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE;3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide;4-[(1E)-2-(1H-INDOL-3-YL)ETHENYL]-1-METHYL-PYRIDINIUM IODIDE
CBNumber: CB5739848
Molecular Formula: C16H15IN2
Formula Weight: 362.21
MOL File: 36098-33-6.mol

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F16 Property

storage temp.: Store at -20°C
solubility: ≤500μg/ml in ethanol;20mg/ml in DMSO;25mg/ml in dimethyl formamide
form: Orange solid.
color: Yellow to orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10022
Product name: F16
Purity: ≥98%
Packaging: 1mg
Price: $14
Updated: 2024/03/01

Cayman Chemical

Product number: 10022
Product name: F16
Purity: ≥98%
Packaging: 5mg
Price: $53
Updated: 2024/03/01

Cayman Chemical

Product number: 10022
Product name: F16
Purity: ≥98%
Packaging: 10mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 10022
Product name: F16
Purity: ≥98%
Packaging: 50mg
Price: $384
Updated: 2024/03/01

TRC

Product number: F118805
Product name: F16
Packaging: 25mg
Price: $95
Updated: 2021/12/16

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F16 Chemical Properties,Usage,Production

Uses

F16 is a cell-permeable mitochondrial toxin with apoptotic and necrotic action in tumor cell lines.

Biological Activity

f16 is a small, cationic, lipophilic, and fluorescent molecule capable of binding preferentially to mitochondrial membranes and disrupts their function. f16 is a potential antitumor agent.f16 affected growth in some mouse and human breast cancer cell lines. f16 resulted in a dramatic decrease in the number of cells in s phase and an increase in the percentage of cells in g1 phase [1]. prolonged incubation with 3 μm f16 led to increased cell death of f16-sensitive cells but not of f16-resistant ones. f16 accumulation in mitochondria induced mitochondrial damage characterized by imbalance of volumetric homeostasis, failure to synthesize atp, cytochrome c release and increased production of reactive oxy gen species [1]. f16 incubation decreased the cellular atp pool in both parental eph4-a6 and bcl-2-overexpressing eph4-a6.c13 and eph4-a6.c18 cells in a time-dependent manner [1]. treatment with f16 promoted early release of cytochrome c in transformed eph4-a6 cells. treatment with f16 (0.3-3 μm) resulted in the characteristic apoptotic dna laddering in the eph4-a6 cells. f16-induced mitochondrial dysfunction triggers apoptosis or necrosis. f16 induced necrosis in various cell lines resistant to apoptosis [2].

References

[1] fantin v r, berardi m j, scorrano l, et al. a novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth[j]. cancer cell, 2002, 2(1): 29-42.
[2] fantin v r, leder p. f16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell[j]. cancer research, 2004, 64(1): 329-336.

F16 Preparation Products And Raw materials

Raw materials

Preparation Products

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F16 Suppliers

China 50 Switzerland 2 United States 8 Global 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

EMD Biosciences, Inc.

Tel: --
Fax: --
Email: technical@calbiochem.com
Country: United States
ProdList: 6529
Advantage: 66

36098-33-6, F16Related Search:

4-Vinylpyridine F16 1 4-DIMETHYLPYRIDINIUM IODIDE 99

F16

4-[(1E)-2-(1H-INDOL-3-YL)ETHENYL]-1-METHYL-PYRIDINIUM IODIDE

4-[(E)-2-(INDOL-3-YL)ETHENYL]-N-METHYLPYRIDINIUM IODIDE

F-16;COMPOUND F16

Compound F16)

F16 (F-16

3-[2-(1-methylpyridin-1-ium-4-yl)ethenyl]-1H-indole,iodide

F16/Cell proliferation inhibitor (F16)

36098-33-6