Methyl 2-chloro-4-fluorobenzoate
- Product Name
- Methyl 2-chloro-4-fluorobenzoate
- CAS No.
- 85953-29-3
- Chemical Name
- Methyl 2-chloro-4-fluorobenzoate
- Synonyms
- RARECHEM AL BF 0289;methyl 2-chloro-4-fluorob...;METHYL 2-CHLORO-4-FLUOROBENZOATE;Methyl2-chloro-4-fluorobenzoate97%;Methyl 2-chloro-4-fluorobenzoate 97%;METHYL 2-CHLORO-4-FLUOROBENZENECARBOXYLATE;2-CHLORO-4-FLUOROBENZOIC ACID METHYL ESTER;Benzoic acid, 2-chloro-4-fluoro-, Methyl ester
- CBNumber
- CB5741128
- Molecular Formula
- C8H6ClFO2
- Formula Weight
- 188.58
- MOL File
- 85953-29-3.mol
Methyl 2-chloro-4-fluorobenzoate Property
- Boiling point:
- 110 °C
- Density
- 1.314±0.06 g/cm3(Predicted)
- refractive index
- 1.5150 to 1.5190
- Flash point:
- 103-105°C/15mm
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Light yellow
- InChI
- InChI=1S/C8H6ClFO2/c1-12-8(11)6-3-2-5(10)4-7(6)9/h2-4H,1H3
- InChIKey
- YZDLPZNWBRBZMZ-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(F)C=C1Cl
- CAS DataBase Reference
- 85953-29-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-36
- Safety Statements
- 26-36/37/39-37/39
- RIDADR
- 1993
- HazardClass
- IRRITANT
- HS Code
- 2916310090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M3102
- Product name
- Methyl 2-Chloro-4-fluorobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- M3102
- Product name
- Methyl 2-Chloro-4-fluorobenzoate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $113
- Updated
- 2025/07/31
- Product number
- M295583
- Product name
- Methyl 2-Chloro-4-fluorobenzoate
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- M295583
- Product name
- Methyl 2-Chloro-4-fluorobenzoate
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2623-7-24
- Product name
- Methyl 2-chloro-4-fluorobenzoate
- Purity
- 98%
- Packaging
- 25g
- Price
- $35
- Updated
- 2021/12/16
Methyl 2-chloro-4-fluorobenzoate Chemical Properties,Usage,Production
Uses
Methyl 2-chloro-4-fluorobenzoate can form complexes with Cu ions for materials chemistry research.
Synthesis
67-56-1
2252-51-9
85953-29-3
General procedure for the synthesis of methyl 2-chloro-4-fluorobenzoate from methanol and 2-chloro-4-fluorobenzoic acid: 2-chloro-4-fluorobenzoic acid (6.5 g, 37 mmol) was dissolved in methanol (100 mL), chlorotrimethylsilane (14.0 mL, 111 mmol) was added, and the reaction was stirred for 24 hours at room temperature. Upon completion of the reaction, the solvent was removed by rotary evaporator. The residue was dissolved in dichloromethane, washed with saturated sodium bicarbonate solution, dried over anhydrous sodium sulfate, and the solvent was again removed by rotary evaporator to afford methyl 2-chloro-4-fluorobenzoate as a light yellow oil (7.01 g, 99% yield). The product was confirmed by 1H-NMR (CDCl3, 500 MHz): δ 7.93 (m, 1H), 7.22 (m, 1H), 7.06 (m, 1H), 3.95 (s, 3H) ppm; mass spectrometry (FIA) showed the molecular ion peaks m/z 189.1 (M + H); and the retention time for the HPLC analysis (Method A) was 3.37 min.
References
[1] Patent: WO2004/46120, 2004, A2. Location in patent: Page 175; 176
[2] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 21, p. 9524 - 9535
[3] European Journal of Medicinal Chemistry, 2015, vol. 90, p. 195 - 208
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 8, p. 3130 - 3141
Methyl 2-chloro-4-fluorobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-chloro-4-fluorobenzoate manufacturers
- Product
- Methyl 2-chloro-4-fluorobenzoate 85953-29-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2019-12-25
- Product
- Methyl 2-Chloro-4-fluorobenzoate 85953-29-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.1%
- Supply Ability
- 100 tons
- Release date
- 2022-01-17
- Product
- Benzoic acid,2-chloro-4-fluoro-, methyl ester 85953-29-3
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09