ChemicalBook > CAS DataBase List > 6-Bromovanillin

6-Bromovanillin

Product Name
6-Bromovanillin
CAS No.
60632-40-8
Chemical Name
6-Bromovanillin
Synonyms
AKOS B004167;6-Bromovanilin;6-BROMOVANILLIN;Vanillin, 6-bromo-;CHEMBRDG-BB 3004167;ART-CHEM-BB B004167;2-BROMO-4-HYDROXY-5-METHOXYBENZALDEHYDE;Benzaldehyde, 2-bromo-4-hydroxy-5-methoxy-;2-bromo-4-hydroxy-5-methoxybenzaldehyde(SALTDATA: FREE);6-BROMOVANILLIN/2-BROMO-4-HYDROXY-5-METHOXYBENZALDEHYDE
CBNumber
CB5748839
Molecular Formula
C8H7BrO3
Formula Weight
231.04
MOL File
60632-40-8.mol
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6-Bromovanillin Property

Melting point:
178 °C
Boiling point:
326.2±37.0 °C(Predicted)
Density 
1.653±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform, DCM, Ethyl Acetate
form 
Solid
pka
6.83±0.23(Predicted)
color 
Brown
CAS DataBase Reference
60632-40-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S107026
Product name
2-BROMO-4-HYDROXY-5-METHOXY-BENZALDEHYDE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$185
Updated
2025/07/31
Sigma-Aldrich
Product number
S107026
Product name
2-BROMO-4-HYDROXY-5-METHOXY-BENZALDEHYDE
Purity
Aldrich
Packaging
100mg
Price
$179
Updated
2024/03/01
TRC
Product number
B689010
Product name
6-Bromovanillin
Packaging
100mg
Price
$120
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB67859
Product name
6-Bromovanillin
Packaging
2g
Price
$125
Updated
2021/12/16
Matrix Scientific
Product number
028658
Product name
2-Bromo-4-hydroxy-5-methoxybenzaldehyde
Packaging
500mg
Price
$126
Updated
2021/12/16
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6-Bromovanillin Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

6-Bromovanillin is used in the synthesis of Carbidopa (C175915), an inhibitor of aromatic amino acid decarboxylase.

Synthesis

881-68-5

60632-40-8

The general procedure for the synthesis of 2-bromo-4-hydroxy-5-methoxybenzaldehyde from acetylvanillin is as follows: 1. 4-Formyl-2-methoxyphenyl acetate (5.00 g) and bromine (1.42 mL) were added to an aqueous solution (120 mL) of potassium bromide (10.3 g) and the mixture was stirred at room temperature for 8 hours. 2. The precipitate was collected by filtration and washed with water. 3. 6N hydrochloric acid (120 mL) was added to the resulting solid and the mixture was stirred at 90 °C for 16 hours. 4. The precipitate was collected by filtration and washed with saturated aqueous sodium bicarbonate and water. 5. The solid obtained was dissolved in ethyl acetate and the mixture was filtered through silica gel to give the title compound as a light yellow solid (yield: 4.88 g). 6. The resulting solid was recrystallized from ethyl acetate/n-heptane to give the title compound as a light yellow solid (yield: 3.98 g, 68%). 1H-NMR (DMSO-d6, 300 MHz): δ 3.83 (3H, s), 7.11 (1H, s), 7.34 (1H, s), 10.01 (1H, s), 10.86 (1H, br s).

References

[1] Journal of Organic Chemistry, 2002, vol. 67, # 18, p. 6493 - 6502
[2] Patent: EP2450352, 2012, A1. Location in patent: Page/Page column 80
[3] Journal of the American Chemical Society, 1927, vol. 49, p. 1079
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 17, p. 1967 - 1972
[5] Helvetica Chimica Acta, 1989, vol. 72, # 7, p. 1554 - 1582

6-Bromovanillin Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Bromovanillin Suppliers

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View Lastest Price from 6-Bromovanillin manufacturers

Career Henan Chemical Co
Product
6-Bromovanillin 60632-40-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kgs
Release date
2020-01-02

60632-40-8, 6-BromovanillinRelated Search:

3,7-Dimethyl-7-hydroxyoctanal o-Anisaldehyde 4-Hydroxybenzaldehyde Vanillin 2,6-Dimethoxybenzaldehyde Ethyl vanillin Salicylaldehyde Benzaldehyde CHLOROPHOSPHONAZO III p-Anisaldehyde 2-Bromo-5-methoxybenzaldehyde Veratraldehyde 3-Methoxysalicylaldehyde (Trifluoromethoxy)benzene 3-Methoxybenzaldehyde Bromine 6-Bromoveratraldehyde 2-BROMO-4,5-DIMETHOXYBENZOIC ACID

  • 6-BROMOVANILLIN
  • AKOS B004167
  • 2-BROMO-4-HYDROXY-5-METHOXYBENZALDEHYDE
  • ART-CHEM-BB B004167
  • CHEMBRDG-BB 3004167
  • 6-BROMOVANILLIN/2-BROMO-4-HYDROXY-5-METHOXYBENZALDEHYDE
  • 2-bromo-4-hydroxy-5-methoxybenzaldehyde(SALTDATA: FREE)
  • Vanillin, 6-bromo-
  • 2-Bromo-4-hydroxy-5-methoxybenzaldehyde (6-Bromovanillin)
  • 6-Bromovanilin
  • Benzaldehyde, 2-bromo-4-hydroxy-5-methoxy-
  • 60632-40-8
  • API intermediates
  • Aromatic Aldehydes & Derivatives (substituted)