6-Bromovanillin
- Product Name
- 6-Bromovanillin
- CAS No.
- 60632-40-8
- Chemical Name
- 6-Bromovanillin
- Synonyms
- AKOS B004167;6-Bromovanilin;6-BROMOVANILLIN;Vanillin, 6-bromo-;CHEMBRDG-BB 3004167;ART-CHEM-BB B004167;2-BROMO-4-HYDROXY-5-METHOXYBENZALDEHYDE;Benzaldehyde, 2-bromo-4-hydroxy-5-methoxy-;2-bromo-4-hydroxy-5-methoxybenzaldehyde(SALTDATA: FREE);6-BROMOVANILLIN/2-BROMO-4-HYDROXY-5-METHOXYBENZALDEHYDE
- CBNumber
- CB5748839
- Molecular Formula
- C8H7BrO3
- Formula Weight
- 231.04
- MOL File
- 60632-40-8.mol
6-Bromovanillin Property
- Melting point:
- 178 °C
- Boiling point:
- 326.2±37.0 °C(Predicted)
- Density
- 1.653±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform, DCM, Ethyl Acetate
- form
- Solid
- pka
- 6.83±0.23(Predicted)
- color
- Brown
- CAS DataBase Reference
- 60632-40-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S107026
- Product name
- 2-BROMO-4-HYDROXY-5-METHOXY-BENZALDEHYDE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
- Product number
- S107026
- Product name
- 2-BROMO-4-HYDROXY-5-METHOXY-BENZALDEHYDE
- Purity
- Aldrich
- Packaging
- 100mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- B689010
- Product name
- 6-Bromovanillin
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FB67859
- Product name
- 6-Bromovanillin
- Packaging
- 2g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 028658
- Product name
- 2-Bromo-4-hydroxy-5-methoxybenzaldehyde
- Packaging
- 500mg
- Price
- $126
- Updated
- 2021/12/16
6-Bromovanillin Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
6-Bromovanillin is used in the synthesis of Carbidopa (C175915), an inhibitor of aromatic amino acid decarboxylase.
Synthesis
881-68-5
60632-40-8
The general procedure for the synthesis of 2-bromo-4-hydroxy-5-methoxybenzaldehyde from acetylvanillin is as follows: 1. 4-Formyl-2-methoxyphenyl acetate (5.00 g) and bromine (1.42 mL) were added to an aqueous solution (120 mL) of potassium bromide (10.3 g) and the mixture was stirred at room temperature for 8 hours. 2. The precipitate was collected by filtration and washed with water. 3. 6N hydrochloric acid (120 mL) was added to the resulting solid and the mixture was stirred at 90 °C for 16 hours. 4. The precipitate was collected by filtration and washed with saturated aqueous sodium bicarbonate and water. 5. The solid obtained was dissolved in ethyl acetate and the mixture was filtered through silica gel to give the title compound as a light yellow solid (yield: 4.88 g). 6. The resulting solid was recrystallized from ethyl acetate/n-heptane to give the title compound as a light yellow solid (yield: 3.98 g, 68%). 1H-NMR (DMSO-d6, 300 MHz): δ 3.83 (3H, s), 7.11 (1H, s), 7.34 (1H, s), 10.01 (1H, s), 10.86 (1H, br s).
References
[1] Journal of Organic Chemistry, 2002, vol. 67, # 18, p. 6493 - 6502
[2] Patent: EP2450352, 2012, A1. Location in patent: Page/Page column 80
[3] Journal of the American Chemical Society, 1927, vol. 49, p. 1079
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 17, p. 1967 - 1972
[5] Helvetica Chimica Acta, 1989, vol. 72, # 7, p. 1554 - 1582
6-Bromovanillin Preparation Products And Raw materials
Raw materials
Preparation Products
6-Bromovanillin Suppliers
- Tel
- --
- Fax
- --
- akos@akosgmbh.de
- Country
- Germany
- ProdList
- 6717
- Advantage
- 72
View Lastest Price from 6-Bromovanillin manufacturers
- Product
- 6-Bromovanillin 60632-40-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kgs
- Release date
- 2020-01-02