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Dithizone

Product Name
Dithizone
CAS No.
60-10-6
Chemical Name
Dithizone
Synonyms
DIPHENYLTHIOCARBAZONE;dithizon;Dithizone (min. 98%);1,5-diphenyl-3-thiocarbazone;(E)-1,5-diphenylthiocarbazone;Diazenecarbothioic acid, 2-phenyl-, 2-phenylhydrazide;Ditizon;DITHIZONE;usafek-3092;DITHIZONE(P)
CBNumber
CB5753569
Molecular Formula
C13H12N4S
Formula Weight
256.33
MOL File
60-10-6.mol
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Dithizone Property

Melting point:
168 °C (dec.) (lit.)
Boiling point:
376.1±25.0 °C(Predicted)
Density 
1.2578 (rough estimate)
refractive index 
1.5700 (estimate)
storage temp. 
no restrictions.
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Crystalline
pka
pK1:4.50;pK2:15 (25°C)
color 
Black powder
Water Solubility 
Soluble in ethanol, chloroform, dimethylsulfoxide, and pyridine. Insoluble in water.
Merck 
14,3377
BRN 
748838
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
60-10-6(CAS DataBase Reference)
EPA Substance Registry System
Diazenecarbothioic acid, phenyl-, 2-phenylhydrazide (60-10-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
22-36/37/38
Safety Statements 
36-26
RIDADR 
2811
WGK Germany 
3
RTECS 
LQ9450000
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
DX2370
Product name
Dithizone
Purity
Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs GR ACS
Packaging
25g
Price
$981
Updated
2024/03/01
Sigma-Aldrich
Product number
1.03092
Product name
Dithizone
Purity
for analysis (1,5-diphenylthiocarbazone) Reag. Ph Eur
Packaging
5G
Price
$158
Updated
2024/03/01
Sigma-Aldrich
Product number
1.03092
Product name
Dithizone
Purity
for analysis (1,5-diphenylthiocarbazone) Reag. Ph Eur
Packaging
25g
Price
$396
Updated
2024/03/01
TCI Chemical
Product number
D0949
Product name
Dithizone
Purity
>85.0%(E)
Packaging
25g
Price
$97
Updated
2024/03/01
Alfa Aesar
Product number
033283
Product name
Dithizone, ACS, 85+%
Packaging
2g
Price
$21.65
Updated
2024/03/01
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Dithizone Chemical Properties,Usage,Production

Chemical Properties

dark brown or black crystals

Uses

Dithizone is an organosulfur compound that acts as a chelating agent and forms complexes with metals such as lead and mercury. Dithizone is used to assess the purity of human pancreatic islet preparations used for transplantation into patients with type 1 diabetes.

Uses

Dithizone is used as an indicator for minute amounts of lead. It acts as a chelating agent for heavy metal poisoning. As a ligand, it forms complexes with metals like zinc, lead and mercury. Further, it is used to assess the purity of human pancreatic islet preparations, which is used for transplantation in patients with type 1 diabetes. In addition to this, it is used as a titrant in the quantitative determination of heavy metals.

Uses

Sensitive reagent for several heavy metals, Co, Cu, Pb, and Hg; especially for the estimation of minute amounts of Pb.

Definition

ChEBI: Dithizone is a member of phenylhydrazines.

General Description

Dithizone (Diphenylthiocarbazone) is used as chelating agent for zinc. It is widely used for the liquid-liquid and solid phase extraction of various metals since it forms stable complexes with the metals.

Purification Methods

The crude dithizone is dissolved in CCl4 to give a concentrated solution. This is filtered through a sintered glass funnel and shaken with 0.8M aqueous ammonia to extract dithizonate ion. The aqueous layer is washed with several portions of CCl4 to remove undesirable materials. The aqueous layer is acidified with dilute H2SO4 to precipitate pure dithizone. This is dried in a vacuum. When only small amounts of dithizone are required, purification by paper chromatography is convenient. [Cooper & Hibbits J Am Chem Soc 75 5084 1933.] Instead of CCl4, CHCl3 can be used, and the final extract, after washing with water, can be evaporated in air at 40-50o and dried in a desiccator. It complexes with Cd, Hg, Ni and Zn. [Beilstein 16 H 26, 16 IV 18.]

Dithizone Preparation Products And Raw materials

Raw materials

Hydrogen Sulfide Diphenyl 4-Chlorobenzaldehyde Potassium hydroxide Congo red paper Thiocarbohydrazide Methanol

Preparation Products

Bleomycin sulfate
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Dithizone Suppliers

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View Lastest Price from Dithizone manufacturers

Watson Biotechnology Co.,Ltd
Product
Dithizone 60-10-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
80%
Supply Ability
20MT
Release date
2024-08-14
Hebei Weibang Biotechnology Co., Ltd
Product
Dithizone 60-10-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-21
R&D Scientific Inc.
Product
Dithizone 60-10-6
Price
US $250.00/g
Min. Order
1g
Purity
96
Supply Ability
500 Kg
Release date
2024-02-18

60-10-6, DithizoneRelated Search:

Bis(cyclohexanone)oxaldihydrazone DIPHENYLCARBAZONE Bithionol Disulfiram Biphenyl Semicarbazide Azobenzene Carbohydrazide Methylhydrazine Phenylhydrazine Thiourea 1-PHENYL-3-THIOSEMICARBAZIDE THIOFORMAMIDE Hydrazinium hydroxide solution 1，2-Dimethyl hydrazine N-Aminothiourea Dithizone

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