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Bleomycin sulfate

Product Name
Bleomycin sulfate
CAS No.
9041-93-4
Chemical Name
Bleomycin sulfate
Synonyms
BLEOMYCIN SULPHATE;BLENOXANE;Bleomycin Sulfate (mixture);BLEOMYCIN SULFATE CELL CULTURE TESTED;BLEO;BLEXANE;Bleolem;BLEOcell;BLEO cell;BLEO-cell
CBNumber
CB8412175
Molecular Formula
C110H168N34O46S7
Formula Weight
2927.17
MOL File
9041-93-4.mol
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Bleomycin sulfate Property

Melting point:
200-204°C (dec.)
storage temp. 
2-8°C
solubility 
H2O: 20 mg/mL
form 
powder
color 
white
Water Solubility 
Soluble in water or DMSO
Merck 
14,1318
Stability:
Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months.
InChI
InChI=1/2C55H83N17O21S3.H2O4S/c2*1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-66-26)91-54-43(39(80)37(78)28(16-73)90-54)92-53-40(81)42(93-55(60)88)38(79)29(17-74)89-53)51(87)67-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-68-27(18-94-32)52-65-15-30(95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h2*14-15,18-19,21-25,28-29,34-43,53-54,64,73-75,77-81H,7-13,16-17,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,66,67,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t2*21-,22+,23+,24-,25-,28-,29+,34+,35+,36-,37+,38+,39-,40-,41-,42+,43-,53-,54-;/s3
InChIKey
OOXTWFJZZAJGKA-YWZNXBAZNA-N
SMILES
[C@@H](C1N=CNC=1)(O[C@@H]1O[C@H]([C@@H](O)[C@H](O)[C@@H]1O[C@@H]1O[C@H](CO)[C@@H](O)[C@@H](OC(=O)N)[C@@H]1O)CO)[C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@H]([C@H](O)C)C(=O)NCCC1SC=C(C2=NC=C(C(=O)NCCC[S+](C)C)S2)N=1)NC(=O)C1=C(C)C(=NC([C@H](CC(=O)N)NC[C@H](N)C(=O)N)=N1)N.[C@@H](C1N=CNC=1)(O[C@@H]1O[C@H]([C@@H](O)[C@H](O)[C@@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@@H](OC(=O)N)[C@@H]1O)CO)CO)[C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@H]([C@H](O)C)C(=O)NCCC1SC=C(C2=NC=C(C(=O)NCCC[S+](C)C)S2)N=1)NC(=O)C1=C(C)C(=NC([C@H](CC(=O)N)NC[C@H](N)C(=O)N)=N1)N.S([O-])([O-])(=O)=O |&1:0,7,9,10,12,14,16,18,21,23,28,32,36,38,40,45,46,82,89,96,103,105,106,108,110,112,114,115,117,122,128,132,134,136,141,142,178,185,r|
CAS DataBase Reference
9041-93-4(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
46-40-36/37/38-63
Safety Statements 
53-36/37-45-36-26
WGK Germany 
3
RTECS 
EC5991990
10
HS Code 
2941906000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H340May cause genetic defects

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B8416
Product name
Bleomycin sulfate from Streptomyces verticillus
Purity
1.5-2.0?units/mg solid, BioReagent, suitable for cell culture
Packaging
15units
Price
$1110
Updated
2024/03/01
Sigma-Aldrich
Product number
B5507
Product name
Bleomycin sulfate from Streptomyces verticillus
Purity
crystalline, 1.5-2.0?U/mg
Packaging
15units
Price
$888
Updated
2024/03/01
Sigma-Aldrich
Product number
B2434
Product name
Bleomycin sulfate from Streptomyces verticillus
Purity
BioXtra, crystalline
Packaging
20mg
Price
$1200
Updated
2024/03/01
Sigma-Aldrich
Product number
1076308
Product name
Bleomycin sulfate
Packaging
15mg
Price
$886
Updated
2024/03/01
TCI Chemical
Product number
B3972
Product name
Bleomycin Sulfate (mixture)
Purity
>85.0%(HPLC)
Packaging
10mg
Price
$193
Updated
2024/03/01
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Bleomycin sulfate Chemical Properties,Usage,Production

Description

Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1?and RNA2. Induces double-strand DNA damage.3?Commonly used to induce lung fibrosis in animal disease models.4,5?Anticancer agent in clinical use.6

Chemical Properties

White Powder

Uses

A group of related glycopeptide antibiotics. Bleomycin A2 is the main component of the bleomycin employed clinically. Antineoplastic

Uses

Bleomycin is a complex of 11 glycopeptide antitumour antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight . Bleomycins have found clinical application in the treatment of a range of tumours. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.

Uses

Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.

Uses

Bleomycin sulfate binds to DNA, and can inhibit DNA synthesis and causes scission of DNA. Cleaves DNA, requires binding to oxygen and a metal ion, such as copper or iron. Able to cleave RNA, but at less and more selective degree. Also reported to induce and regulate apoptosis in a variety of cells, and inhibit tumor angiogenesis.

brand name

Blenoxane (Bristol-Myers Squibb).

General Description

Bleomycin occurs as a white powder and is available in 15-and 30-U vials for reconstitution in water. It may be givenintravenously, intramuscularly, or subcutaneously. It is used in the treatment of squamous cell carcinoma of the headneck, cervix, penis, and vulva. It is also used in Hodgkin’sand non-Hodgkin’s lymphoma as well as testicular carcinoma.Unlabeled uses include the treatment of mycosis fungoides,osteosarcoma, and AIDS-related Kaposi sarcoma.

Biochem/physiol Actions

Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.

Clinical Use

Bleomycin is used IV in the palliative treatment of squamous cell head and neck cancers, testicular and other genital carcinomas, and Hodgkin's and non-Hodgkin's lymphoma.

Side effects

It is excreted via the kidneys, and serum concentrations of active drug are increased in patients with renal disease. The elimination half-life can rise from 2 to 4 hours to more than 20 hours in renal failure, resulting in significant toxicity, especially pulmonary toxicity.

Veterinary Drugs and Treatments

Bleomycin has occasionally been used as adjunctive treatment of lymphomas, squamous cell carcinomas, teratomas, and nonfunctional thyroid tumors in both dogs and cats. Recent work has demonstrated that bleomycin may be promising for intralesional treatment for a variety of localized tumors with or without concomitant electropermeabilization.

target

UT-SCC-129 cells

References

1) Petering?et al.?(1990),?The role of redox-active metals in the mechanism of action of bleomycin; Chem. Biol. Interact.,?73?133 2) Huttenhofer?et al. (1992),?Cleavage of tRNA by Fe(II)-bleomycin; J. Biol. Chem.,?267?24471 3) Lee?et al.?(2017)?ASF1a Promotes Non-homologous End Joining Repair by facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks;?Mol. Cell?68?61 4)?Xie?et al.?(2016), Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis; Respir. Res.,?17?103 5) Inomata?et al. (2014) Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis; Respir. Res.,?15?16 6) Tanaka?et al. (2008)?Increased glutathione level is not involved in enhanced bleomycin sensitivity in cisplatin-resistant 2780CP cells; Anticancer Res.,?28?2663

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Bleomycin sulfate Suppliers

HUBEI MICRO PHARMACEUTICAL
Tel
18627055345
Email
info@micropharm.cn
Country
China
ProdList
66
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58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58
Raw material medicin reagent co.,Ltd
Tel
Email
sales@njromanme.com
Country
China
ProdList
4529
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
3983
Advantage
58
Hubei Chenxin Pharmaceutical Co., Ltd.
Tel
17362916295 17362916295
Fax
QQ:840947394
Email
w17362916295@163.com
Country
China
ProdList
3022
Advantage
58
Shanghai Zhibang Biological Medicine Co., LTD
Tel
021-54285032 18116461626
Fax
021-54285032
Email
25493162@qq.com
Country
China
ProdList
142
Advantage
58
Jiangxi ravel Biotechnology Co.,Ltd
Tel
400-880-2824 15608648206
Email
1987516016@qq.com
Country
China
ProdList
2772
Advantage
58
Taizhou Creating Bio-pharm Co.,Ltd.
Tel
+86-0576-88827176 +86-18906581668
Email
post@creatingchemical.com
Country
China
ProdList
228
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9272
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from Bleomycin sulfate manufacturers

S&Y Biochem Co.,Ltd
Product
Bleomycin sulfate 9041-93-4
Price
US $400.00/g
Min. Order
1g
Purity
99
Supply Ability
1000
Release date
2024-08-01
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Bleomycin Sulfate 9041-93-4
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-09-05
Hebei Weibang Biotechnology Co., Ltd
Product
Bleomycin sulfate 9041-93-4
Price
US $1.00/PCS
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2021-05-13

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  • 9041-93-4
  • C110H168N34O46S7
  • C55H84N17O21S3HSO4
  • C50H75N17O25S3
  • A2C55H84N17O21S3
  • 2C55H84N17O21S3O4S
  • C55H85N17O25S4
  • C55H84O17N21S3