Bleomycin sulfate
- Product Name
- Bleomycin sulfate
- CAS No.
- 9041-93-4
- Chemical Name
- Bleomycin sulfate
- Synonyms
- BLEOMYCIN SULPHATE;BLENOXANE;Bleomycin Sulfate (mixture);BLEOMYCIN SULFATE CELL CULTURE TESTED;BLEO;BLEXANE;Bleolem;BLEOcell;BLEO cell;BLEO-cell
- CBNumber
- CB8412175
- Molecular Formula
- C110H168N34O46S7
- Formula Weight
- 2927.17
- MOL File
- 9041-93-4.mol
Bleomycin sulfate Property
- Melting point:
- 200-204°C (dec.)
- storage temp.
- 2-8°C
- solubility
- H2O: 20 mg/mL
- form
- powder
- color
- white
- Water Solubility
- Soluble in water or DMSO
- Merck
- 14,1318
- Stability:
- Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months.
- CAS DataBase Reference
- 9041-93-4(CAS DataBase Reference)
Safety
- Hazard Codes
- T,Xi
- Risk Statements
- 46-40-36/37/38-63
- Safety Statements
- 53-36/37-45-36-26
- WGK Germany
- 3
- RTECS
- EC5991990
- F
- 10
- HS Code
- 2941906000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H340May cause genetic defects
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B8416
- Product name
- Bleomycin sulfate from Streptomyces verticillus
- Purity
- 1.5-2.0?units/mg solid, BioReagent, suitable for cell culture
- Packaging
- 15units
- Price
- $1110
- Updated
- 2024/03/01
- Product number
- B5507
- Product name
- Bleomycin sulfate from Streptomyces verticillus
- Purity
- crystalline, 1.5-2.0?U/mg
- Packaging
- 15units
- Price
- $888
- Updated
- 2024/03/01
- Product number
- B2434
- Product name
- Bleomycin sulfate from Streptomyces verticillus
- Purity
- BioXtra, crystalline
- Packaging
- 20mg
- Price
- $1200
- Updated
- 2024/03/01
- Product number
- 1076308
- Product name
- Bleomycin sulfate
- Packaging
- 15mg
- Price
- $886
- Updated
- 2024/03/01
- Product number
- B3972
- Product name
- Bleomycin Sulfate (mixture)
- Purity
- >85.0%(HPLC)
- Packaging
- 10mg
- Price
- $193
- Updated
- 2024/03/01
Bleomycin sulfate Chemical Properties,Usage,Production
Description
Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1?and RNA2. Induces double-strand DNA damage.3?Commonly used to induce lung fibrosis in animal disease models.4,5?Anticancer agent in clinical use.6
Chemical Properties
White Powder
Uses
A group of related glycopeptide antibiotics. Bleomycin A2 is the main component of the bleomycin employed clinically. Antineoplastic
Uses
Bleomycin is a complex of 11 glycopeptide antitumour antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight . Bleomycins have found clinical application in the treatment of a range of tumours. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.
Uses
Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.
Uses
Bleomycin sulfate binds to DNA, and can inhibit DNA synthesis and causes scission of DNA. Cleaves DNA, requires binding to oxygen and a metal ion, such as copper or iron. Able to cleave RNA, but at less and more selective degree. Also reported to induce and regulate apoptosis in a variety of cells, and inhibit tumor angiogenesis.
brand name
Blenoxane (Bristol-Myers Squibb).
General Description
Bleomycin occurs as a white powder and is available in 15-and 30-U vials for reconstitution in water. It may be givenintravenously, intramuscularly, or subcutaneously. It is used in the treatment of squamous cell carcinoma of the headneck, cervix, penis, and vulva. It is also used in Hodgkin’sand non-Hodgkin’s lymphoma as well as testicular carcinoma.Unlabeled uses include the treatment of mycosis fungoides,osteosarcoma, and AIDS-related Kaposi sarcoma.
Biochem/physiol Actions
Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.
Clinical Use
Bleomycin is used IV in the palliative treatment of squamous cell head and neck cancers, testicular and other genital carcinomas, and Hodgkin's and non-Hodgkin's lymphoma.
Side effects
It is excreted via the kidneys, and serum concentrations of active drug are increased in patients with renal disease. The elimination half-life can rise from 2 to 4 hours to more than 20 hours in renal failure, resulting in significant toxicity, especially pulmonary toxicity.
Veterinary Drugs and Treatments
Bleomycin has occasionally been used as adjunctive treatment of lymphomas, squamous cell carcinomas, teratomas, and nonfunctional thyroid tumors in both dogs and cats. Recent work has demonstrated that bleomycin may be promising for intralesional treatment for a variety of localized tumors with or without concomitant electropermeabilization.
target
UT-SCC-129 cells
References
1) Petering?et al.?(1990),?The role of redox-active metals in the mechanism of action of bleomycin; Chem. Biol. Interact.,?73?133 2) Huttenhofer?et al. (1992),?Cleavage of tRNA by Fe(II)-bleomycin; J. Biol. Chem.,?267?24471 3) Lee?et al.?(2017)?ASF1a Promotes Non-homologous End Joining Repair by facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks;?Mol. Cell?68?61 4)?Xie?et al.?(2016), Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis; Respir. Res.,?17?103 5) Inomata?et al. (2014) Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis; Respir. Res.,?15?16 6) Tanaka?et al. (2008)?Increased glutathione level is not involved in enhanced bleomycin sensitivity in cisplatin-resistant 2780CP cells; Anticancer Res.,?28?2663
Bleomycin sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
Bleomycin sulfate Suppliers
- Tel
- 027-027-59212684 19107121455
- Fax
- QQ:2188308251
- p19107121455@163.com
- Country
- China
- ProdList
- 1797
- Advantage
- 58
- Tel
- 400-400-400-9004166 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52712
- Advantage
- 58
- Tel
- 025-57798860
- sales@njromanme.com
- Country
- China
- ProdList
- 4534
- Advantage
- 58
- Tel
- 15869524721
- 3525679403@qq.com
- Country
- China
- ProdList
- 3915
- Advantage
- 58
- Tel
- 17362916295 17362916295
- Fax
- QQ:840947394
- w17362916295@163.com
- Country
- China
- ProdList
- 3026
- Advantage
- 58
- Tel
- 021-54285032 18116461626
- Fax
- 021-54285032
- 25493162@qq.com
- Country
- China
- ProdList
- 133
- Advantage
- 58
- Tel
- 400-880-2824 15608648206
- 1987516016@qq.com
- Country
- China
- ProdList
- 2543
- Advantage
- 58
- Tel
- +86-0576-88827176 +86-18906581668
- post@creatingchemical.com
- Country
- China
- ProdList
- 226
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
View Lastest Price from Bleomycin sulfate manufacturers
- Product
- Bleomycin sulfate 9041-93-4
- Price
- US $15.00/kg
- Min. Order
- 1kg
- Purity
- 99.912%
- Supply Ability
- 10ton
- Release date
- 2024-04-25
- Product
- Bleomycin sulfate 9041-93-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-09-07
- Product
- Bleomycin sulfate 9041-93-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-07-03