ChemicalBook > CAS DataBase List > ITE

ITE

Product Name
ITE
CAS No.
448906-42-1
Chemical Name
ITE
Synonyms
ITE;ARYL HYDROCARBON RECEPTOR LIGAND;ITE,Aryl Hydrocarbon Receptor,Inhibitor,inhibit,AhR;Methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate;2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID;methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate;2-(1H-INDOL-3-YLCARBONYL)-4-THIAZOLECARBOXYLIC ACID METHYL ESTER;2-(1'H-indole-37-carbonyl)-thiasole-4-carboxylic acid methyl ester;4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester
CBNumber
CB5754713
Molecular Formula
C14H10N2O3S
Formula Weight
286.31
MOL File
448906-42-1.mol
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ITE Property

Melting point:
234 - 236°C
Boiling point:
520.4±48.0 °C(Predicted)
Density 
1.427±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 30 mg/mL, soluble
form 
solid
pka
14.38±0.30(Predicted)
color 
Off-White to Light Yellow
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Tocris
Product number
1803
Product name
ITE
Purity
≥98%(HPLC)
Packaging
10
Price
$231
Updated
2021/12/16
Usbiological
Product number
452797
Product name
ITE
Packaging
1mg
Price
$305
Updated
2021/12/16
TRC
Product number
I942030
Product name
ITE
Packaging
1mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-5141
Product name
ITE
Purity
99.27%
Packaging
5mg
Price
$119
Updated
2021/12/16
ApexBio Technology
Product number
A8615
Product name
ITE
Packaging
10mg
Price
$158
Updated
2021/12/16
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ITE Chemical Properties,Usage,Production

Uses

ITE is an endogenous AHR ligand that parenterally or orally induces FoxP3+ Treg that suppress exprimental autoimmune encephalomyelitis. ITE promotes the induction of active immunology tolerance and identifies nontoxic endogenous AHR ligands.

Definition

ChEBI: 2-[1H-indol-3-yl(oxo)methyl]-4-thiazolecarboxylic acid methyl ester is an indolyl carboxylic acid.

Biological Activity

Endogenous agonist for the transcription factor aryl hydrocarbon receptor (AHR); K i = 3 nM for binding to murine AHR. Transactivates DRE-containing reporter gene constructs in Hepa1c1c7 cells ~ 5-fold more potently than β -naphthoflavone. Active in vivo .

storage

Store at RT

ITE Preparation Products And Raw materials

Raw materials

Preparation Products

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ITE Suppliers

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View Lastest Price from ITE manufacturers

Career Henan Chemical Co
Product
ITE 448906-42-1
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

448906-42-1, ITERelated Search:


  • ITE
  • 2-(1H-INDOL-3-YLCARBONYL)-4-THIAZOLECARBOXYLIC ACID METHYL ESTER
  • 2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID
  • 2-(1'H-indole-37-carbonyl)-thiasole-4-carboxylic acid methyl ester
  • Methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate
  • methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate
  • ARYL HYDROCARBON RECEPTOR LIGAND
  • 4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester
  • ITE,Aryl Hydrocarbon Receptor,Inhibitor,inhibit,AhR
  • 448906-42-1
  • C14H10N2O3S