ITE

ChemicalBook > CAS DataBase List > ITE

Product Name: ITE
CAS No.: 448906-42-1
Chemical Name: ITE
Synonyms: ITE;ARYL HYDROCARBON RECEPTOR LIGAND;ITE,Aryl Hydrocarbon Receptor,Inhibitor,inhibit,AhR;Methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate;2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID;methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate;2-(1H-INDOL-3-YLCARBONYL)-4-THIAZOLECARBOXYLIC ACID METHYL ESTER;2-(1'H-indole-37-carbonyl)-thiasole-4-carboxylic acid methyl ester;4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester
CBNumber: CB5754713
Molecular Formula: C14H10N2O3S
Formula Weight: 286.31
MOL File: 448906-42-1.mol

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ITE Property

Melting point:: 234 - 236°C
Boiling point:: 520.4±48.0 °C(Predicted)
Density: 1.427±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 30 mg/mL, soluble
form: solid
pka: 14.38±0.30(Predicted)
color: Off-White to Light Yellow

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Tocris

Product number: 1803
Product name: ITE
Purity: ≥98%(HPLC)
Packaging: 10
Price: $231
Updated: 2021/12/16

Usbiological

Product number: 452797
Product name: ITE
Packaging: 1mg
Price: $305
Updated: 2021/12/16

TRC

Product number: I942030
Product name: ITE
Packaging: 1mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-5141
Product name: ITE
Purity: 99.27%
Packaging: 5mg
Price: $119
Updated: 2021/12/16

ApexBio Technology

Product number: A8615
Product name: ITE
Packaging: 10mg
Price: $158
Updated: 2021/12/16

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ITE Chemical Properties,Usage,Production

Uses

ITE is an endogenous AHR ligand that parenterally or orally induces FoxP3+ Treg that suppress exprimental autoimmune encephalomyelitis. ITE promotes the induction of active immunology tolerance and identifies nontoxic endogenous AHR ligands.

Definition

ChEBI: 2-[1H-indol-3-yl(oxo)methyl]-4-thiazolecarboxylic acid methyl ester is an indolyl carboxylic acid.

Biological Activity

Endogenous agonist for the transcription factor aryl hydrocarbon receptor (AHR); K i = 3 nM for binding to murine AHR. Transactivates DRE-containing reporter gene constructs in Hepa1c1c7 cells ~ 5-fold more potently than β -naphthoflavone. Active in vivo .

storage

Store at RT

ITE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ITE manufacturers

Career Henan Chemical Co

Product: ITE 448906-42-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

448906-42-1, ITERelated Search:

4-Thiazolecarboxylic acid 2-acetylthiazole-4-carboxylic acid ITE 2-ACETYL-4-METHYLTHIAZOLE, 97%

ITE

2-(1H-INDOL-3-YLCARBONYL)-4-THIAZOLECARBOXYLIC ACID METHYL ESTER

2-(1'H-INDOLE-3'-CARBONYL)-THIAZOLE-4-CARBOXYLIC ACID

2-(1'H-indole-37-carbonyl)-thiasole-4-carboxylic acid methyl ester

Methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate

methyl 2-(1H-indole-3-carbonyl)-1,3-thiazole-4-carboxylate

ARYL HYDROCARBON RECEPTOR LIGAND

4-Thiazolecarboxylic acid, 2-(1H-indol-3-ylcarbonyl)-, methyl ester

ITE,Aryl Hydrocarbon Receptor,Inhibitor,inhibit,AhR

448906-42-1

C14H10N2O3S