7-Hydroxy-1-tetralone
- Product Name
- 7-Hydroxy-1-tetralone
- CAS No.
- 22009-38-7
- Chemical Name
- 7-Hydroxy-1-tetralone
- Synonyms
- 7-hydroxy-3,4-dihydronaphthalen-1(2H)-one;4-dihydro-7-hydroxy-;7-HYDROXY-1-TETRALONE;7-hydroxyl-1-tetralone;Agomelatine Impurity 48;7-Hydroxy-1-tetralone 99%;Allisartan Isoproxil Impurity 24;7-hydroxy-1-tetrahydronaphthalone;7- Hydroxyl -1-tetrahydronaphthalene;7-Hydroxy-3,4-dihydro-2H-1-naphthone
- CBNumber
- CB5754753
- Molecular Formula
- C10H10O2
- Formula Weight
- 162.19
- MOL File
- 22009-38-7.mol
7-Hydroxy-1-tetralone Property
- Melting point:
- 164.0 to 168.0 °C
- Boiling point:
- 215°C/12mmHg(lit.)
- Density
- 1.236±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 9.44±0.20(Predicted)
- color
- White to Gray to Brown
- InChI
- InChI=1S/C10H10O2/c11-8-5-4-7-2-1-3-10(12)9(7)6-8/h4-6,11H,1-3H2
- InChIKey
- LGFSAJZSDNYVCW-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC(O)=C2)CCC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- H1650
- Product name
- 7-Hydroxy-1-tetralone
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- H1650
- Product name
- 7-Hydroxy-1-tetralone
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $157
- Updated
- 2025/07/31
- Product number
- H990900
- Product name
- 7-Hydroxy-1-tetralone
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- H990900
- Product name
- 7-Hydroxy-1-tetralone
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- H990900
- Product name
- 7-Hydroxy-1-tetralone
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
7-Hydroxy-1-tetralone Chemical Properties,Usage,Production
Uses
7-Hydroxy-1-tetralone, its derivatives and related fluorescent chalcones have been used as pharmacological tools to study the human histamine H3 receptor. Also C7-Substituted α-Tetralone derivatives have been study as Inhibitors of Monoamine Oxidase.
Synthesis
6836-19-7
22009-38-7
Under nitrogen protection, 7-methoxy-3,4-dihydronaphthalen-1(2H)-one (25 g, 142 mmol) was slowly added to a suspension of anhydrous toluene (250 mL) containing aluminum trichloride (37.8 g, 283 mmol). The reaction mixture was heated with stirring at 110 °C for 1 hour and then cooled to room temperature. Subsequently, the mixture was further cooled to 0 °C (under ice bath conditions) and water (100 mL) was slowly added to quench the reaction. The organic material in the aqueous phase was extracted with ethyl acetate (100 mL x 3), the organic phases were combined and dried with anhydrous magnesium sulfate. After filtration to remove the desiccant, the filtrate was concentrated to dryness under reduced pressure. The crude product was ground with methanol to give 19.3 g of white solid in 90% yield. The product required further purification. Thin layer chromatography (TLC) analysis (unfolding agent ratio 3:7 ethyl acetate/hexane) showed a single spot with an Rf value of 0.26. The melting point of the product was measured to be 164-166 °C (literature value 165-167 °C).
References
[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 7, p. 1068 - 1083
[2] Tetrahedron Letters, 1997, vol. 38, # 50, p. 8749 - 8752
[3] Tetrahedron Letters, 2014, vol. 55, # 3, p. 682 - 685
[4] Patent: US6248766, 2001, B1
[5] Patent: US2008/280991, 2008, A1. Location in patent: Page/Page column 37
7-Hydroxy-1-tetralone Preparation Products And Raw materials
Raw materials
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View Lastest Price from 7-Hydroxy-1-tetralone manufacturers
- Product
- 7-Hydroxy-1-tetralone 22009-38-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- 7-Hydroxy-1-tetralone 22009-38-7
- Price
- US $10.00-81.00/g
- Min. Order
- 5g
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2023-12-20
- Product
- 7-Hydroxy-1-tetralone 22009-38-7
- Price
- US $786.00/Kg
- Min. Order
- 0.100Kg
- Purity
- 99
- Supply Ability
- 5000 Kg
- Release date
- 2024-10-07