BOC-11-AMINOUNDECANOIC ACID
- Product Name
- BOC-11-AMINOUNDECANOIC ACID
- CAS No.
- 10436-25-6
- Chemical Name
- BOC-11-AMINOUNDECANOIC ACID
- Synonyms
- BOC-11-AUN-OH;BOC-NH-(CH2)10-COOH;Boc-11-aminoundecanoicaci;BOC-11-AMINOUNDECYLIC ACID;BOC-11-AMINOUNDECANOIC ACID;Boc-11-Aun-OH >=98.0% (TLC);N-BOC-11-Aminoundecanoic acid;11-(BOC-AMINO)-UNDECANOIC ACID;REF DUPL: Boc-11-Aminoundecanoic acid;N-ALPHA-T-BOC-11-AMINOUNDECANOIC ACID
- CBNumber
- CB5765102
- Molecular Formula
- C16H31NO4
- Formula Weight
- 301.42
- MOL File
- 10436-25-6.mol
BOC-11-AMINOUNDECANOIC ACID Property
- Melting point:
- 67-68 °C
- Boiling point:
- 441.9±18.0 °C(Predicted)
- Density
- 1.006±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 4.78±0.10(Predicted)
- color
- White to Almost white
- BRN
- 1975656
- InChI
- InChI=1S/C16H31NO4/c1-16(2,3)21-15(20)17-13-11-9-7-5-4-6-8-10-12-14(18)19/h4-13H2,1-3H3,(H,17,20)(H,18,19)
- InChIKey
- HPTPZJBSQUULAV-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCCCCCCCCCNC(OC(C)(C)C)=O
- CAS DataBase Reference
- 10436-25-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 00045
- Product name
- Boc-11-Aun-OH
- Purity
- ≥98.0% (TLC)
- Packaging
- 2.5g
- Price
- $152
- Updated
- 2022/05/15
- Product number
- B6018
- Product name
- 11-[(tert-Butoxycarbonyl)amino]undecanoic Acid
- Packaging
- 5G
- Price
- $86
- Updated
- 2025/07/31
- Product number
- B6018
- Product name
- 11-[(tert-Butoxycarbonyl)amino]undecanoic Acid
- Packaging
- 25G
- Price
- $297
- Updated
- 2025/07/31
- Product number
- B809865
- Product name
- Boc-11-AminoundecanoicAcid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 05443
- Product name
- Boc-11-aminoundecanoicacid,95%
- Purity
- 95%
- Packaging
- 5G
- Price
- $67.2
- Updated
- 2021/12/16
BOC-11-AMINOUNDECANOIC ACID Chemical Properties,Usage,Production
Description
Boc-11-aminoundecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Chemical Properties
White powder
Uses
Boc-11-aminoundecanoic acid is an Alkyl/ether-based?PROTAC linker?can be used in the synthesis of MS432 (HY-130602)[1].
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
2432-99-7
24424-99-5
10436-25-6
General procedure for the synthesis of Boc-11-aminoundecanoic acid from 11-aminoundecanoic acid and di-tert-butyl dicarbonate: 160 g of 11-aminoundecanoic acid, 2 liters of dioxane, 1.3 liters of distilled water, 208 g of sodium carbonate, and 173 g of di-tert-butyl dicarbonate were added sequentially to a 4-liter three-necked flask in a unit equipped with a mechanical stirrer and reflux condenser. The reaction mixture was heated to boiling point and the reaction was continued with stirring for 16 hours to obtain a clarified solution. Upon completion of the reaction, the mixture was cooled to 20 °C and subsequently poured into 800 g of ice and the pH was adjusted to 3-4 with 4 N hydrochloric acid, at which point a white precipitate was produced. The precipitate was separated by filtration, washed with 300 cm3 of water and then dried under reduced pressure at 20 °C (20 mm Hg, 2.7 kPa) to give 232 g of N-(tert-butoxycarbonyl)-11-aminoundecanoic acid in 95% yield. The melting point of the product (68°C) is in agreement with that reported in the literature J. Org. Chem. 1997,1987.Chem., 41,1350 (1976).
IC 50
Alkyl/ether
References
[1] Wei J, et al.Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.J Med Chem. 2019 Dec 12;62(23):10897-10911. DOI:10.1021/acs.jmedchem.9b01528
BOC-11-AMINOUNDECANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BOC-11-AMINOUNDECANOIC ACID manufacturers
- Product
- Boc-11-aminoundecanoic acid 10436-25-6
- Price
- US $0.00-0.00/Kg
- Min. Order
- 100G
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-16
- Product
- BOC-11-AMINOUNDECANOIC ACID 10436-25-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 10tons
- Release date
- 2020-01-20