ChemicalBook > CAS DataBase List > BOC-11-AMINOUNDECANOIC ACID

BOC-11-AMINOUNDECANOIC ACID

Product Name: BOC-11-AMINOUNDECANOIC ACID
CAS No.: 10436-25-6
Chemical Name: BOC-11-AMINOUNDECANOIC ACID
Synonyms: BOC-11-AUN-OH;BOC-NH-(CH2)10-COOH;Boc-11-aminoundecanoicaci;BOC-11-AMINOUNDECYLIC ACID;BOC-11-AMINOUNDECANOIC ACID;Boc-11-Aun-OH >=98.0% (TLC);N-BOC-11-Aminoundecanoic acid;11-(BOC-AMINO)-UNDECANOIC ACID;REF DUPL: Boc-11-Aminoundecanoic acid;N-ALPHA-T-BOC-11-AMINOUNDECANOIC ACID
CBNumber: CB5765102
Molecular Formula: C16H31NO4
Formula Weight: 301.42
MOL File: 10436-25-6.mol

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BOC-11-AMINOUNDECANOIC ACID Property

Melting point:: 67-68 °C
Boiling point:: 441.9±18.0 °C(Predicted)
Density: 1.006±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 4.78±0.10(Predicted)
color: White to Almost white
BRN: 1975656
InChI: InChI=1S/C16H31NO4/c1-16(2,3)21-15(20)17-13-11-9-7-5-4-6-8-10-12-14(18)19/h4-13H2,1-3H3,(H,17,20)(H,18,19)
InChIKey: HPTPZJBSQUULAV-UHFFFAOYSA-N
SMILES: C(O)(=O)CCCCCCCCCCNC(OC(C)(C)C)=O
CAS DataBase Reference: 10436-25-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2924.19.8000
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 00045
Product name: Boc-11-Aun-OH
Purity: ≥98.0% (TLC)
Packaging: 2.5g
Price: $152
Updated: 2022/05/15

TCI Chemical

Product number: B6018
Product name: 11-[(tert-Butoxycarbonyl)amino]undecanoic Acid
Packaging: 5G
Price: $86
Updated: 2025/07/31

TCI Chemical

Product number: B6018
Product name: 11-[(tert-Butoxycarbonyl)amino]undecanoic Acid
Packaging: 25G
Price: $297
Updated: 2025/07/31

TRC

Product number: B809865
Product name: Boc-11-AminoundecanoicAcid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Chem-Impex

Product number: 05443
Product name: Boc-11-aminoundecanoicacid,≥95%
Purity: ≥95%
Packaging: 1G
Price: $17.47
Updated: 2021/12/16

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BOC-11-AMINOUNDECANOIC ACID Chemical Properties,Usage,Production

Description

Boc-11-aminoundecanoic acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

White powder

Uses

Boc-11-aminoundecanoic acid is an Alkyl/ether-based?PROTAC linker?can be used in the synthesis of MS432 (HY-130602)[1].

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

2432-99-7

24424-99-5

10436-25-6

General procedure for the synthesis of Boc-11-aminoundecanoic acid from 11-aminoundecanoic acid and di-tert-butyl dicarbonate: 160 g of 11-aminoundecanoic acid, 2 liters of dioxane, 1.3 liters of distilled water, 208 g of sodium carbonate, and 173 g of di-tert-butyl dicarbonate were added sequentially to a 4-liter three-necked flask in a unit equipped with a mechanical stirrer and reflux condenser. The reaction mixture was heated to boiling point and the reaction was continued with stirring for 16 hours to obtain a clarified solution. Upon completion of the reaction, the mixture was cooled to 20 °C and subsequently poured into 800 g of ice and the pH was adjusted to 3-4 with 4 N hydrochloric acid, at which point a white precipitate was produced. The precipitate was separated by filtration, washed with 300 cm3 of water and then dried under reduced pressure at 20 °C (20 mm Hg, 2.7 kPa) to give 232 g of N-(tert-butoxycarbonyl)-11-aminoundecanoic acid in 95% yield. The melting point of the product (68°C) is in agreement with that reported in the literature J. Org. Chem. 1997,1987.Chem., 41,1350 (1976).

IC 50

Alkyl/ether

References

[1] Wei J, et al.Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.J Med Chem. 2019 Dec 12;62(23):10897-10911. DOI:10.1021/acs.jmedchem.9b01528

BOC-11-AMINOUNDECANOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BOC-11-AMINOUNDECANOIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Boc-11-aminoundecanoic acid 10436-25-6
Price: US $0.00-0.00/Kg
Min. Order: 100G
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-16

Career Henan Chemical Co

Product: BOC-11-AMINOUNDECANOIC ACID 10436-25-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%HPLC
Supply Ability: 10tons
Release date: 2020-01-20

10436-25-6, BOC-11-AMINOUNDECANOIC ACIDRelated Search:

Undecanedioic acid 11-Aminoundecanoic acid 2-(1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL)CYCLOHEXANECARBOXYLIC ACID BOC-11-AMINOUNDECANOIC ACID

BOC-11-AMINOUNDECANOIC ACID

BOC-11-AMINOUNDECYLIC ACID

BOC-11-AUN-OH

BOC-NH-(CH2)10-COOH

11-(BOC-AMINO)-UNDECANOIC ACID

T-BUTOXYCARBONYL-11-AMINOUNDECANOIC ACID

T-BUTOXYCARBONYL-11-AMINOUNDECYLIC ACID

N-TERT-BUTYLOXYCARBONYL-11-AMINO-UNDECANOIC ACID

N-ALPHA-T-BOC-11-AMINOUNDECANOIC ACID

N-T-BUTYLOXYCARBONYL-11-AMINO-UNDECANOIC ACID

REF DUPL: Boc-11-Aminoundecanoic acid

Boc-11-AMinoundecanoic acid Boc-11-AMinoundecanoic acid

Boc-11-Aun-OH >=98.0% (TLC)

N-(tert-Butoxycarbonyl)-11-aminoundecanoic acid

Undecanoic acid, 11-[[(1,1-dimethylethoxy)carbonyl]amino]-

Boc-11-aminoundecanoicaci

11-[(2-methylpropan-2-yl)oxycarbonylamino]undecanoic acid

10436-25-6 BOC-11-AMINOUNDECANOIC ACID

N-BOC-11-Aminoundecanoic acid

10436-25-6

C16H31NO4

Linear Core Amino Acids

Unnatural Amino Acid Derivatives

Specialty Synthesis

Peptide Synthesis

Amino Acids