1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE

Product Name: 1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE
CAS No.: 77286-66-9
Chemical Name: 1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Synonyms: EDELFOSINE;ET-18-OCH3;SN-ET-18-OCH3;RAC-ET-18-OCH3;2-O-METHYL PAF C-18;18:0-1:0 DIETHER PC;Edelfosine (ET-18-OCH3);2-O-METHYL-1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE;1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE;1-O-OCTADECYL-2-O-METHYL-RAC-GLYCERO-3-PHOSPHOCHOLINE
CBNumber: CB5768198
Molecular Formula: C27H58NO6P
Formula Weight: 523.73
MOL File: 77286-66-9.mol

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1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE Property

storage temp.: -20°C
solubility: ethanol: 15 mg/mL at 45 °C, soluble
form: waxy solid
color: white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2923200000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 60912
Product name: 2-O-methyl PAF C-18
Purity: ≥98%
Packaging: 5mg
Price: $42
Updated: 2021/12/16

Cayman Chemical

Product number: 60912
Product name: 2-O-methyl PAF C-18
Purity: ≥98%
Packaging: 10mg
Price: $80
Updated: 2021/12/16

Cayman Chemical

Product number: 60912
Product name: 2-O-methyl PAF C-18
Purity: ≥98%
Packaging: 50mg
Price: $336
Updated: 2021/12/16

Cayman Chemical

Product number: 60912
Product name: 2-O-methyl PAF C-18
Purity: ≥98%
Packaging: 100mg
Price: $571
Updated: 2021/12/16

Tocris

Product number: 3022
Product name: Edelfosine
Packaging: 10
Price: $129
Updated: 2021/12/16

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1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

Edelfosine or 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine might be used:

as a non-hydrolysable LysoPC (phospholipid) analog for analyzing its ability to block sexual commitment in Plasmodium falciparum
in multilamellar vesicle preparation to study its effect on model membranes
in the selection and screening of mutagenized cells, having the ability to inhibit the transport of alkylphosphocholine drugs across the plasma membrane

Definition

ChEBI: (R)-edelfosine is a 1-octadecyl-2-methylglycero-3-phosphocholine that is the (R)-enantiomer of edelfosine.

Biological Activity

Synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C. Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.

Biochem/physiol Actions

Edelfosine acts as a precursor for alkyl-lysophospholipids. It possesses apoptotic action against several cancer cells such as prostate, leukemia, brain and lung tumors. It is associated with cellular transport system, signaling transducing systems, cytokine synthesis and lipid metabolism. Edelfosine is known to control intracellular?calcium levels. It is not mutagenic and its anti-tumor action requires its incorporation into the cell. Edelfosine is also found to block the replication of human immunodeficiency virus type I (HIV-I).

1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE Suppliers

Belgium 1 China 47 Japan 1 Switzerland 5 The Netherlands 1 United Kingdom 4 United States 16 USA 1 Global 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
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Chemsky (shanghai) International Co.,Ltd

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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Sigma-Aldrich

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EMMX Biotechnology LLC

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Codow Chemical Co.,Ltd.

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Shanghai EFE Biological Technology Co., Ltd.

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Chengdu Dianchun Technology Co., Ltd

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Aikon International Limited

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Shanghai Jizhi Biochemical Technology Co. Ltd.

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77286-66-9, 1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINERelated Search:

Cisplatin Carboplatin Arctiin (-)-Arctigenin Oridonin pristimerin Pyrrolcarbonyltaloside gamma-Linolenic acid Baccatine III Oxaliplatin Isorhamnetin PAF (C18) 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE 3-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-1-PHOSPHOCHOLINE 1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE

RAC-ET-18-OCH3

SN-ET-18-OCH3

L-A-PHOSPHATIDYLCHOLINE-B-O-METHYL- GAMM A-O-OCTADECYL

2-O-METHYL-1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE

(7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide

1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE;EDELFOSINE

ET-18-OCH3

EDELFOSINE

18:0-1:0 DIETHER PC

2-O-METHYL PAF C-18

1-O-OCTADECYL-2-O-METHYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE

1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE

1-O-OCTADECYL-2-O-METHYL-RAC-GLYCERO-3-PHOSPHOCHOLINE

1-O-OCTADECYL-2-O-METHYL-RAC-GLYCERO-3-PHOSPHORYLCHOLINE

1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE

Edelfosine (ET-18-OCH3)

(R)-2-Methoxy-3-(octadecyloxy)propyl (2-(trimethylammonio)ethyl) phosphate

1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine hydrate

77286-66-9

777286-66-9