Ecabet sodium
- Product Name
- Ecabet sodium
- CAS No.
- 86408-72-2
- Chemical Name
- Ecabet sodium
- Synonyms
- Gastrom;ta-2711;TA-2711E;ECABET SODIUM;Ecabate sodium;Ecabetsodiumsalt;ECABET SODIUM,99+%;1), (1R,4aS,10aR)-;Ecabet Sodium JP16;Ecabet Sodium Impurity
- CBNumber
- CB5769786
- Molecular Formula
- C20H29NaO5S
- Formula Weight
- 404.5
- MOL File
- 86408-72-2.mol
Ecabet sodium Property
- Melting point:
- >300°
- alpha
- D20 +59.4° (c = 0.5)
- storage temp.
- Store at -20°C
- solubility
- DMF: 25 mg/ml; DMSO: 30 mg/ml; Ethanol: 3 mg/ml; PBS (pH 7.2): 3 mg/ml
- form
- A crystalline solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 28013
- Product name
- Ecabet (sodium salt)
- Packaging
- 10mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 28013
- Product name
- Ecabet (sodium salt)
- Packaging
- 25mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 28013
- Product name
- Ecabet (sodium salt)
- Packaging
- 5mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- U154
- Product name
- Ecabetsodium
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- CS-0020410
- Product name
- Ecabetsodium
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $55
- Updated
- 2021/12/16
Ecabet sodium Chemical Properties,Usage,Production
Description
Ecabet sodium is a new antiulcer agent launched in Japan for the treatment of gastric ulcer. It has both mucosal-protective and tissue-repairing properties. In rats, it effectively prevents gastrointestinal lesion formation induced experimentally by EtOH, HCl, NaOH, and boiling water. The mechanism of action has been suggested to involve inhibition of pepsin activity in gastric juice by precipitating pepsin in the form of a complex and inactivating pepsinogen.
Originator
Tanabe (Japan)
Uses
Ecabet sodium (TA-2711) is currently applied to some gastrointestinal disease by inhibiting the ROS production and improving Helicobacter pylori eradication[1]. Ecabet sodium reduces apoptosis[2].
brand name
Gastrom
Synthesis
33159-27-2
86408-72-2
Synthesis of sodium (4bS,8R,8aR)-8-carboxy-2-isopropyl-4b,8-dimethyl-4b,5,6,7,8,8a,9,10,10-octahydro-phenanthrene-3-sulfonate from (1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-6-sulfo-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene-1-carboxylic acid The general procedure for the salt was as follows: the feedstock compound (II) (80 g, 0.210 mol) was added to a 25% aqueous solution of sodium isooctanoate (36.6 g, 0.221 mol) and the reaction was stirred for 0.5 to 1 hour. The mixture was then heated until it was completely dissolved and showed clarification, after which it was thermally filtered. The filtrate was cooled to 0°C to 10°C to induce precipitation of a large white solid. The precipitate was separated by filtration and the filter cake was dried under reduced pressure to give the target product (I) as a white solid. The product was characterized as follows: specific spin of +72° (water), moisture content of 18.06%, HPLC purity of more than 99.5%, chemical content of 99.98%, and total yield of 87.5%.
References
[1] Wang Y, et al. Efficacy and safety of ecabet sodium as an adjuvant therapy for Helicobacter pylori eradication: a systematic review and meta-analysis. Helicobacter. 2014 Oct;19(5):372-81. DOI:10.1111/hel.12136
[2] Rah YC, et al. Ecabet sodium alleviates neomycin-induced hair cell damage. Free Radic Biol Med. 2015 Dec;89:1176-83. DOI:10.1016/j.freeradbiomed.2015.11.007
[3] Kenji Kusumoto, et al. Ecabet sodium inhibits Helicobacter pylori lipopolysaccharide-induced activation of NADPH oxidase 1 or apoptosis of guinea pig gastric mucosal cells. Am J Physiol Gastrointest Liver Physiol DOI:10.1152/ajpgi.00274.2004
Ecabet sodium Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ecabet sodium manufacturers
- Product
- Ecabet Sodium Impurity 86408-72-2
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 98
- Supply Ability
- 10000000
- Release date
- 2025-02-22
- Product
- Ecabet Sodium 86408-72-2
- Price
- US $10.70/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-20
- Product
- Ecabet sodium 86408-72-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10