L-Hyoscyamine

ChemicalBook > CAS DataBase List > L-Hyoscyamine

Product Name: L-Hyoscyamine
CAS No.: 101-31-5
Chemical Name: L-Hyoscyamine
Synonyms: HYOSCYAMINE;APOA;(-)-Hycosamine;AK38;L-(P);Levsin;SEPSECS;Levsinex;DATURINE;Cystospaz
CBNumber: CB5772230
Molecular Formula: C17H23NO3
Formula Weight: 289.37
MOL File: 101-31-5.mol

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L-Hyoscyamine Property

Melting point:: 108,5°C
Boiling point:: 431.53°C (rough estimate)
alpha: D20 -21.0° (alc)
Density: 1.0470 (rough estimate)
refractive index: 1.5200 (estimate)
storage temp.: 2-8°C
solubility: DMSO:79.0(Max Conc. mg/mL);273.0(Max Conc. mM)
Ethanol:58.0(Max Conc. mg/mL);200.43(Max Conc. mM)
form: powder
pka: pKa (21°) 9.7
color: white
Water Solubility: 3.6g/L(20 ºC)
Merck: 14,4858
InChIKey: RKUNBYITZUJHSG-FXUDXRNXSA-N
LogP: 1.380 (est)
CAS DataBase Reference: 101-31-5(CAS DataBase Reference)
NIST Chemistry Reference: Hyoscyamine(101-31-5)
EPA Substance Registry System: Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (.alpha.S)- (101-31-5)

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Safety

Hazard Codes: T+
Risk Statements: 26/28
Safety Statements: 24-45
RIDADR: UN 1544 6.1/PG 2
WGK Germany: 3
RTECS: NH0875000
HazardClass: 6.1
PackingGroup: I
HS Code: 29339900
Hazardous Substances Data: 101-31-5(Hazardous Substances Data)
Toxicity: man,LDLo,unreported,1471ug/kg (1.471mg/kg),"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H370Causes damage to organs

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: HPA070409
Product name: Anti-SEPSECS antibody produced in rabbit
Purity: Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
Packaging: 100μL
Price: $580
Updated: 2024/03/01

Sigma-Aldrich

Product number: HPA070409
Product name: Anti-SEPSECS antibody produced in rabbit
Purity: Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
Packaging: 25μL
Price: $282
Updated: 2023/06/20

Cayman Chemical

Product number: 25644
Product name: (?)-Hyoscyamine
Purity: ≥98%
Packaging: 250mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 25644
Product name: (?)-Hyoscyamine
Purity: ≥98%
Packaging: 500mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 25644
Product name: (?)-Hyoscyamine
Purity: ≥98%
Packaging: 1g
Price: $87
Updated: 2024/03/01

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L-Hyoscyamine Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Uses

Suggested starting dilutions are as follows: IHC-P: 1:100-1:1000, WB: 1:1000-1:10000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Uses

L-Hyoscyamine can be used as anticholinergic and analgesic.

Uses

L-Hyoscyamine is a natural compound that has inhibitory activity against cholinesterases.

Definition

ChEBI: An atropine with a 2S-configuration.

General Description

Hyoscyamine is a levorotatory alkaloidobtained from various solanaceous species. One ofthe commercial sources is Egyptian henbane (Hyoscyamusmuticus), in which it occurs to the extent of about 0.5%.Usually, it is prepared from the crude drug in a manner similarto that used for atropine and is purified as the oxalate.The free base is obtained easily from this salt.
It occurs as white needles that are sparingly soluble inwater (1:281), more soluble in ether (1:69) or benzene(1:150), very soluble in chloroform (1:1), and freely solublein alcohol. It is used as the sulfate and hydrobromide. Theprincipal reason for the popularity of the hydrobromide hasbeen its nondeliquescent nature. The salts have the advantageover the free base in being quite water soluble.

Biochem/physiol Actions

The 21st amino acid, selenocysteine (sec), is distinct from other amino acids because it lacks its own tRNA synthetase and is the only amino acid synthesized on its cognate tRNA. Synthesis of sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) by seryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec), which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase (PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECS catalyzes the final step of sec synthesis by converting O-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) using selenophosphate as the selenium donor (Palioura et al., 2009 [PubMed 19608919]).[supplied by OMIM]

Clinical Use

(L-Hyoscyamine)Hyoscyamine is used to treat disorders of the urinarytract more so than any other antispasmodic, although thereis no evidence that it has any advantages over the otherbelladonna preparations and the synthetic anticholinergics.It is used to treat spasms of the bladder and, in this manner,serves as a urinary stimulant. It is used together witha narcotic to counteract the spasm produced by the narcoticwhen the latter is used to relieve the pain of urethral colic.Hyoscyamine preparations are also used as antispasmodicsin the therapy of peptic ulcers.

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AChR

L-Hyoscyamine Preparation Products And Raw materials

Raw materials

ExtracuM Belladonnae

Preparation Products

Atropine sulfate monohydrate

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L-Hyoscyamine Suppliers

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View Lastest Price from L-Hyoscyamine manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Hyoscyamine 101-31-5
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 100 g
Release date: 2020-08-13

Dideu Industries Group Limited

Product: L-Hyoscyamine 101-31-5
Price: US $1.10/g
Min. Order: 1g
Purity: 0.999
Supply Ability: 100 Tons min
Release date: 2021-08-03

Zhuozhou Wenxi import and Export Co., Ltd

Product: L-Hyoscyamine 101-31-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

101-31-5, L-HyoscyamineRelated Search:

Kresoxim-methyl Atropine Tribenuron methyl Atropine sulfate monohydrate METSULFURON METHYL ANISODAMINE Methyl salicylate Methyl acetate Scopolamine butylbromide Racanisodamine Atropine sulfate 3-(4-Hydroxyphenyl)propionic acid L(+)-Lactic acid Scopolamine hydrobromide Thiophanate-methyl CHLOROPHOSPHONAZO III HYOSCINE N BUTYL BROMIDE BP Methyl

(-)-hyoscyamin

L-Hyoscyamine free base

[3(S)-ENDO]-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER, ALPHA-(HYDROXYMETHYL)-BENZENEACETIC ACID

L-Hyoscyamine (Daturine)

L-HYOSCYAMINE FREE BASE CRYSTALLINE

Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo3.2.1oct-3-yl ester, (.alpha.S)-

HYOSCYAMINE,USP

L-(P)

(S)-Atropine

1αH,5αH-Tropan-3α-yl (-)-tropate

Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (αS)-

Benzeneacetic acid, α-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, [3(S)-endo]-

l-Atropine

L-Hyoscyamin

Tropic acid, 1αH,5αH-tropan-3α-yl ester, (-)- (8CI)

HYOSCYAMINEL

(8-Methyl-8-azabicyclo[3.2.1]octan-3-yl) (2S)-3-hydroxy-2-phenylpropanoate

[3(S)-endo]-α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

[S,(-)]-α-(Hydroxymethyl)benzeneacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3α-yl

Alpha-(Hydroxymethyl)-Benzeneaceticaci8-Methyl-8-Azabicyclo[3.2.1]

HYOSCYAMINE, L-(P)

(-)-Hycosamine

(2S)-(1R,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate

(-)-tropicaciesterwithtropine

(3(s)-endo)-leste

(S)-(-)-Hyoscyamine

[3(s)-endo]-leste

1-Hyoscyamine

alpha-(hydroxymethyl)-benzeneaceticaci8-methyl-8-azabicyclo(3.2.1)oct-3-y

alpha-(hydroxymethyl)-benzeneaceticaci8-methyl-8-azabicyclo[3.2.1]oct-3-y

Cystospaz

Duboisine

Hyocyamine

Levsin

Levsinex

l-Hyopscyamine

L-Hyoscamine

Tropic acid, 1alphaH,5alphaH-tropan-3alpha-yl ester, (-)-

L-HYOSCYAMINE

L-DATURINE

L-DUBOISINE

L-TROPINE TROPATE

DATURINE

(-)-HYOSCYAMINE

HYOSCYAMINE

BENZENEACETIC ACID, ALPHA-(HYDROXYMETHYL)-, 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER, [3(S)-ENDO]

Benzeneacetic acid, a-(hydroxymethyl)-,(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (aS)-

(-)-Hyoscyamine, 97%, from Atropa belladonna L.

Anti-SEPSECS antibody produced in rabbit

DKFZp434B1417

MGC161491

SEPSECS

AK38

APOA

Monoclonal Anti-LPA antibody produced in mouse

Belladonna Liquid Extract/hyoscyamine

(2S)-3-hydroxy-2-phenylpropanoic acid [(1R,5S)-8-methyl-8-azoniabicyclo[3.2.1]octan-3-yl] ester

Hyoscamine