Atropine sulfate
- Product Name
- Atropine sulfate
- CAS No.
- 55-48-1
- Chemical Name
- Atropine sulfate
- Synonyms
- ATROPINE SULPHATE;atropinsulfat;Ryuato;eyesule;corbella;atropisal;NSC 26671;davurtrop;atropette;Tropintran
- CBNumber
- CB8315445
- Molecular Formula
- 2C17H23NO3.H2O4S
- Formula Weight
- 676.82
- MOL File
- 55-48-1.mol
Atropine sulfate Property
- Melting point:
- 189-192 °C (A)(lit.)
- Boiling point:
- 135 °C
- Density
- 1.1172 (rough estimate)
- refractive index
- 1.6900 (estimate)
- storage temp.
- 0-6°C
- solubility
- Soluble in DMSO
- color
- Crystals
- InChIKey
- HOBWAPHTEJGALG-AADVZIIPNA-N
- CAS DataBase Reference
- 55-48-1(CAS DataBase Reference)
- EPA Substance Registry System
- Atropine sulfate (55-48-1)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H330Fatal if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P284Wear respiratory protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P310Immediately call a POISON CENTER or doctor/physician.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P330Rinse mouth.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-4835
- Product name
- Atropine Sulfate
- Purity
- 98.07%
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- API0006577
- Product name
- ATROPINE SULFATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $728
- Updated
- 2021/12/16
- Product number
- CFN90575
- Product name
- Atropine Sulfate
- Packaging
- 20mg
- Price
- $198
- Updated
- 2021/12/16
Atropine sulfate Chemical Properties,Usage,Production
Uses
anticholinergic agent
Uses
cholinergic receptor antagonist
brand name
Atrophate [Veterinary] (Schering-Plough Animal Health); Atropisol (Ciba Vision, US Ophthalmics); Isopto Atropine (Alcon).
General Description
Atropine sulfate (Atropisol)is prepared by neutralizing atropine in acetone or ethersolution with an alcoholic solution of sulfuric acid, withcare used to prevent hydrolysis. The salt occurs as colorlesscrystals or as a white, crystalline powder. It is efflorescentin dry air and should be protected from light to preventdecomposition.
Atropine sulfate is freely soluble in water (1:0.5), in alcohol(1:5, 1:2.5 at boiling point), and in glycerin (1:2.5).Aqueous solutions are not very stable, although solutionsmay be sterilized at 120°C (15 lb pressure) in an autoclave if the pH is kept below 6. Sterilization probably is besteffected by the use of aseptic techniques and a bacteriologicalfilter. It has been suggested that no more than a 30-daysupply of an aqueous solution should be made and that forsmall quantities the best procedure is to use hypodermictablets and sterile distilled water. Kondritzer andZvirblis have studied the kinetics of alkaline and protoncatalyzedhydrolyses of atropine in aqueous solution. Theregion of maximal stability lies between pH 3 and approximately5. They have also proposed an equation to predictthe half-life of atropine undergoing hydrolysis at constantpH and temperature.
Clinical Use
Atropine may be used to treat some types of arrhythmias. Itincreases the heart rate by blocking the effects of ACh on thevagus. In this context, it is used to treat certain reversible bradyarrhythmiasthat may accompany acute myocardial infarction.It is also used as an adjunct to anesthesia to protect againstbradycardia, hypotension, and even cardiac arrest induced bythe skeletal muscle relaxant succinylcholine chloride.
Another use for atropine sulfate emerged following thedevelopment of the organophosphates, which are potent inhibitorsof AChE. Atropine is a specific antidote to preventthe muscarinic effects of ACh accumulation, such as vomiting,abdominal cramps, diarrhea, salivation, sweating, bronchoconstriction,and excessive bronchial secretions. It isused intravenously but does not protect against respiratoryfailure caused by depression of the respiratory center andthe muscles of respiration.
Safety Profile
Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human (child) pulmonary system effects by ingestion. Human systemic effects: decreased body temperature, cardiac arrhythmias. An experimental teratogen. Other experimental reproductive effects. See also ATROPINE. When heated to decomposition it emits very toxic fumes of NO,xand SOx.
Veterinary Drugs and Treatments
The principal veterinary indications for systemic atropine include:
!!Preanesthetic to prevent or reduce secretions of the respiratory
tract
!!Treat sinus bradycardia, sinoatrial arrest, and incomplete AV
block
!!Differentiate vagally-mediated bradycardia for other causes
!!As an antidote for overdoses of cholinergic agents (e.g., physostigmine,
etc.)
!!As an antidote for organophosphate, carbamate, muscarinic
mushroom, blue-green algae intoxication
!!Hypersialism
!!Treatment of bronchoconstrictive disease
Atropine sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Atropine sulfate manufacturers
- Product
- Atropine sulfate 55-48-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98.00%
- Supply Ability
- 1000kg
- Release date
- 2022-12-10
- Product
- Atropine sulfate API 55-48-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 10 tons
- Release date
- 2024-03-18
- Product
- Atropine sulfate 55-48-1
- Price
- US $625.00/kg
- Min. Order
- 0.1kg
- Purity
- 99% min
- Supply Ability
- 20 tons
- Release date
- 2022-10-13