Atropine sulfate monohydrate

Product Name: Atropine sulfate monohydrate
CAS No.: 5908-99-6
Chemical Name: Atropine sulfate monohydrate
Synonyms: ATRAZINE;HYOSCYAMINE SULFATE;α-(hydroxymethyl)-benzeneacetic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate, hydrate (2:1:1);Atropt;Atropsiol;TROPINI SULFAS;AtropineSulfat;ATROPINI SULFAS;atropiniumsulfat;racemic anisodamine
CBNumber: CB7339477
Molecular Formula: C17H25NO7S
Formula Weight: 387.45
MOL File: 5908-99-6.mol

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Atropine sulfate monohydrate Property

Melting point:: 189-192 °C (A)(lit.)
alpha: -0.6 º (per USP 25 ºC)
storage temp.: Poison room
solubility: H2O: soluble2.5g/mL (stable for several days at 4°C.)
form: Powder
color: white
Water Solubility: soluble
Sensitive: Light Sensitive
Merck: 14,875
BRN: 6109275
Stability:: Hygroscopic
LogP: 2.137 (est)
CAS DataBase Reference: 5908-99-6(CAS DataBase Reference)

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Safety

Hazard Codes: T+
Risk Statements: 26/28-43-36/37/38
Safety Statements: 23-45-36/37/39-26-1-25
RIDADR: UN 1544 6.1/PG 2
WGK Germany: 2
RTECS: CK2455000
F: 3-8-10
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29399900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A0257
Product name: Atropine sulfate salt monohydrate
Purity: ≥97% (TLC), crystalline
Packaging: 5g
Price: $110
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1045009
Product name: Atropine sulfate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP023
Product name: Atropine sulfate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 200MG
Price: $320
Updated: 2023/06/20

Alfa Aesar

Product number: A10236
Product name: Atropine sulfate monohydrate, 98+%
Packaging: 10g
Price: $64
Updated: 2023/06/20

Alfa Aesar

Product number: A10236
Product name: Atropine sulfate monohydrate, 98+%
Packaging: 50g
Price: $232
Updated: 2023/06/20

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Atropine sulfate monohydrate Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

Anticholinergic;Muscarinic antagonist

Uses

mydriatic and anticholinergie agent in ophthalmie preparations and pre-anesthetie medications; antidote to organophosphous insecticides

Uses

Atropine sulfate is mydriatic; antispasmodic; used in preanesthetic medication.

Application

Atropine sulfate monohydrate is an alkaloid derived from belladonna, a cholinergic receptor antagonist drug, which has been shown to be a competitive non-selective antagonist of central and peripheral mAChR M (muscarinic acetylcholine receptor). It can be used in the treatment of cardiac arrhythmias. Atropine Sulfate is also used as a pharmaceutical reference standard for a variety of analytical applications.

Application

brand name

Atrophate [Veterinary] (Schering-Plough Animal Health); Atropisol (Ciba Vision, US Ophthalmics); Isopto Atropine (Alcon).

General Description

Atropine is isolated from Atropa belladonna, Datura stramonium and Mandragora officinarum. It is a tertiary amine, which acts as a cholinergic receptor antagonist.

Biological Activity

atropine is a competitive antagonist of muscarinic acetylcholine receptor with ic50 values of 2.22±0.60nm, 4.32±1.63nm, 4.16±1.04nm, 2.38±1.07nm and 3.39±1.16nm for m1, m2, m3, m4 and m5, respectively [1].atropine is an antimuscarinic agent and has shown the pharmacological effects because of binding to muscarinic acetylcholine receptors. atropine, the orthosteric antagonist, has been reported to compete with [3h]-nms for all muscarinic subtypes with a potency consistent with the high affinities at the machr subtypes. the ki values are 1.27±0.36nm, 3.24±1.16nm, 2.21±0.53nm, 0.77±0.43nm and 2.84±0.84nm, respectively [1, 2, 3].

References

[1] lebois ep1, bridges tm, lewis lm, dawson es, kane as, xiang z, jadhav sb, yin h, kennedy jp, meiler j, niswender cm, jones ck, conn pj, weaver cd, lindsley cw. discovery and characterization of novel subtype-selective allosteric agonists for the investigation of m(1) receptor function in the central nervous system.acs chem neurosci. 2010;1(2):104-121.
[2] busch h, allen h, anderson dc.effects of atropine and carbachol on labeling of protein fractions of mouse pancreas in vitro.j pharmacol exp ther. 1959 nov; 127:200-4.
[3] feron o1, smith tw, michel t, kelly ra.dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. j biol chem. 1997 jul 11; 272(28):17744-8.

Atropine sulfate monohydrate Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID Atropine DIETHOXYMETHANE L-Hyoscyamine Carbon tetrachloride

Preparation Products

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Atropine sulfate monohydrate Suppliers

Americas 1 Belgium 3 Brazil 1 Canada 2 China 246 Europe 4 France 1 Germany 6 Hungary 1 India 33 Italy 2 Japan 7 Mexico 1 Poland 1 Russia 1 Switzerland 2 The Netherlands 1 United Kingdom 14 United States 52 Global 379

Wuhan Chujiang Haoyu Chemical Technology Development Co., Ltd.

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J & K SCIENTIFIC LTD.

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Meryer (Shanghai) Chemical Technology Co., Ltd.

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Alfa Aesar

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Energy Chemical

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LGM Pharma

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Chemsky（shanghai）International Co.,Ltd.

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View Lastest Price from Atropine sulfate monohydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Atropine sulfate monohydrate 5908-99-6
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 98.5%~101.0%; USP34
Supply Ability: 2000kg/month
Release date: 2021-06-02

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Belladonna Extract
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 12%; 40% HPLC
Supply Ability: no limitation
Release date: 2022-10-19

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Atropine sulfate monohydrate 5908-99-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: ≥98% HPLC
Supply Ability: 1000kg
Release date: 2022-10-19

5908-99-6, Atropine sulfate monohydrateRelated Search:

Methylparaben Methyl acrylate Aluminum sulfate 2-Hydroxyphenylacetic acid Sodium sulfate 4-Methoxyphenylacetic acid Kresoxim-methyl MELIBIOSE Atropine Thiophanate-methyl Bensulfuron methyl Ammonium sulfate 4-Hydroxyphenylacetic acid sulfate Methyl Atropine sulfate CYCLOHEPTYLAMINE HYOSCYAMINE SULFATE DIHYDRATE,HYOSCYAMINE SULFATE

Atropsiol

8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate sulfate (2:1) hydrate (salt)

HYOSCYAMINE SULFATE

ATROPINE SULPHATE MONOHYDRATE

ATROPINI SULFAS

ATROPINE SULFATE MONOHYDRATE

ATROPINE SULFATE SALT MONOHYDRATE

ALPHA-(HYDROXYMETHYL)BENZENEACETIC ACID 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER MONOHYDRATE

TROPINE TROPATE MONOHYDRATE

TROPINI SULFAS

ATROPINE SULFATE MONOHYDRATE, PH EUR

AtropineSulphateGrPuriss

AtropineSulphateB.P.ExAtropaBelladonna

Atropinesulfatemonohydrate,98%

ATROPINE SULFATE 1-HYDRATE

ATROPINE SULFATE 1-HYDRATE, POWDER, PHARMA

Atropine sulfate monohydrate, 98.50%

Benzeneacetic acid, .alpha.-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo3.2.1oct-3-yl ester, sulfate (2:1) (salt), monohydrate

ATROPINESULFATE,MONOHYDRATE,CP

ATROPINESULFATE,MONOHYDRATE,POWDER,USP

HYOSCYAMINE SULFATE(RG)

atropine sulfate crystalline

Atropine Sulfate (Monohydrate Salt)

α-(hydroxymethyl)-benzeneacetic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate, hydrate (2:1:1)

Benorilate Solution, 100ppm

ATRAZINE

ATROPINE SULFATE, MONOHYDRATE USP

alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate monohydrate

Atropine Sulfate Hydrate

Atropt

α-(Hydroxymethyl)benzeneacetic Acid (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl Ester Sulfate Hydrate

a-(Hydroxymethyl)benzeneacetic Acid (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl Ester Sulfate Hydrate

Atropine sulphate monohydrate, 98+%

Tropine tropate, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

Atropine monohydrate sulfate salt

Atropini sulfas, Tropine tropate, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

[(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate sulfuric acid hydrate

a-(Hydroxymethyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-(+/-)-, sulfate (2:1) (salt), monohydrate

Benzeneacetic acid, a-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, sulfate (2:1) (salt), monohydrate

1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (±)-tropate (ester), sulfate (2:1) salt monohydrate

α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

AtropineSulfat

Atropine Sulfate (500 mg)

racemic anisodamine

Atropine sulfate monohydrate,98.5%

Atropine Sulfate RS

Atropine sulfate CRS

Atropine sulfate hydrate (2:1:1)

Atropine sulfate monohydrate USP/EP/BP

tropine sulfate monohydrate

(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate

Atropine sulfate (A1400000)

[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate

Atropine Sulfate (1045009)

ATROPINE SULPHATE MONOHYDRATE AR

Bis[(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2RS)-3-hydroxy-2-phenylpropanoate] sulfate monohydrate

atropiniumsulfat

Atropine Sulfate Atropine Sulfate Monohydrate