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Atropine sulfate monohydrate

Product Name
Atropine sulfate monohydrate
CAS No.
5908-99-6
Chemical Name
Atropine sulfate monohydrate
Synonyms
ATRAZINE;HYOSCYAMINE SULFATE;α-(hydroxymethyl)-benzeneacetic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate, hydrate (2:1:1);Atropt;Atropsiol;TROPINI SULFAS;AtropineSulfat;ATROPINI SULFAS;atropiniumsulfat;racemic anisodamine
CBNumber
CB7339477
Molecular Formula
C17H25NO7S
Formula Weight
387.45
MOL File
5908-99-6.mol
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Atropine sulfate monohydrate Property

Melting point:
189-192 °C (A)(lit.)
alpha 
-0.6 º (per USP 25 ºC)
storage temp. 
Poison room
solubility 
H2O: soluble2.5g/mL (stable for several days at 4°C.)
form 
Powder
color 
white
Water Solubility 
soluble
Sensitive 
Light Sensitive
Merck 
14,875
BRN 
6109275
Stability:
Hygroscopic
LogP
2.137 (est)
CAS DataBase Reference
5908-99-6(CAS DataBase Reference)
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Safety

Hazard Codes 
T+
Risk Statements 
26/28-43-36/37/38
Safety Statements 
23-45-36/37/39-26-1-25
RIDADR 
UN 1544 6.1/PG 2
WGK Germany 
2
RTECS 
CK2455000
F 
3-8-10
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29399900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A0257
Product name
Atropine sulfate salt monohydrate
Purity
≥97% (TLC), crystalline
Packaging
5g
Price
$110
Updated
2024/03/01
Sigma-Aldrich
Product number
1045009
Product name
Atropine sulfate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
BP023
Product name
Atropine sulfate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
200MG
Price
$320
Updated
2023/06/20
Alfa Aesar
Product number
A10236
Product name
Atropine sulfate monohydrate, 98+%
Packaging
10g
Price
$64
Updated
2023/06/20
Alfa Aesar
Product number
A10236
Product name
Atropine sulfate monohydrate, 98+%
Packaging
50g
Price
$232
Updated
2023/06/20
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Atropine sulfate monohydrate Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

Anticholinergic;Muscarinic antagonist

Uses

mydriatic and anticholinergie agent in ophthalmie preparations and pre-anesthetie medications; antidote to organophosphous insecticides

Uses

Atropine sulfate is mydriatic; antispasmodic; used in preanesthetic medication.

Application

Atropine sulfate monohydrate is an alkaloid derived from belladonna, a cholinergic receptor antagonist drug, which has been shown to be a competitive non-selective antagonist of central and peripheral mAChR M (muscarinic acetylcholine receptor). It can be used in the treatment of cardiac arrhythmias. Atropine Sulfate is also used as a pharmaceutical reference standard for a variety of analytical applications.

Application

brand name

Atrophate [Veterinary] (Schering-Plough Animal Health); Atropisol (Ciba Vision, US Ophthalmics); Isopto Atropine (Alcon).

General Description

Atropine is isolated from Atropa belladonna, Datura stramonium and Mandragora officinarum. It is a tertiary amine, which acts as a cholinergic receptor antagonist.

Biological Activity

atropine is a competitive antagonist of muscarinic acetylcholine receptor with ic50 values of 2.22±0.60nm, 4.32±1.63nm, 4.16±1.04nm, 2.38±1.07nm and 3.39±1.16nm for m1, m2, m3, m4 and m5, respectively [1].atropine is an antimuscarinic agent and has shown the pharmacological effects because of binding to muscarinic acetylcholine receptors. atropine, the orthosteric antagonist, has been reported to compete with [3h]-nms for all muscarinic subtypes with a potency consistent with the high affinities at the machr subtypes. the ki values are 1.27±0.36nm, 3.24±1.16nm, 2.21±0.53nm, 0.77±0.43nm and 2.84±0.84nm, respectively [1, 2, 3].

References

[1] lebois ep1, bridges tm, lewis lm, dawson es, kane as, xiang z, jadhav sb, yin h, kennedy jp, meiler j, niswender cm, jones ck, conn pj, weaver cd, lindsley cw. discovery and characterization of novel subtype-selective allosteric agonists for the investigation of m(1) receptor function in the central nervous system.acs chem neurosci. 2010;1(2):104-121.
[2] busch h, allen h, anderson dc.effects of atropine and carbachol on labeling of protein fractions of mouse pancreas in vitro.j pharmacol exp ther. 1959 nov; 127:200-4.
[3] feron o1, smith tw, michel t, kelly ra.dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. j biol chem. 1997 jul 11; 272(28):17744-8.

Atropine sulfate monohydrate Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID Atropine DIETHOXYMETHANE L-Hyoscyamine Carbon tetrachloride

Preparation Products

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View Lastest Price from Atropine sulfate monohydrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Atropine sulfate monohydrate 5908-99-6
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98.5%~101.0%; USP34
Supply Ability
2000kg/month
Release date
2021-06-02
Changsha Staherb Natural Ingredients Co., Ltd.
Product
Belladonna Extract
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
12%; 40% HPLC
Supply Ability
no limitation
Release date
2022-10-19
Changsha Staherb Natural Ingredients Co., Ltd.
Product
Atropine sulfate monohydrate 5908-99-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥98% HPLC
Supply Ability
1000kg
Release date
2022-10-19

5908-99-6, Atropine sulfate monohydrateRelated Search:

Methylparaben Methyl acrylate Aluminum sulfate 2-Hydroxyphenylacetic acid Sodium sulfate 4-Methoxyphenylacetic acid Kresoxim-methyl MELIBIOSE Atropine Thiophanate-methyl Bensulfuron methyl Ammonium sulfate 4-Hydroxyphenylacetic acid sulfate Methyl Atropine sulfate CYCLOHEPTYLAMINE HYOSCYAMINE SULFATE DIHYDRATE,HYOSCYAMINE SULFATE

  • Atropsiol
  • 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate sulfate (2:1) hydrate (salt)
  • HYOSCYAMINE SULFATE
  • ATROPINE SULPHATE MONOHYDRATE
  • ATROPINI SULFAS
  • ATROPINE SULFATE MONOHYDRATE
  • ATROPINE SULFATE SALT MONOHYDRATE
  • ALPHA-(HYDROXYMETHYL)BENZENEACETIC ACID 8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL ESTER MONOHYDRATE
  • TROPINE TROPATE MONOHYDRATE
  • TROPINI SULFAS
  • ATROPINE SULFATE MONOHYDRATE, PH EUR
  • AtropineSulphateGrPuriss
  • AtropineSulphateB.P.ExAtropaBelladonna
  • Atropinesulfatemonohydrate,98%
  • ATROPINE SULFATE 1-HYDRATE
  • ATROPINE SULFATE 1-HYDRATE, POWDER, PHARMA
  • Atropine sulfate monohydrate, 98.50%
  • Benzeneacetic acid, .alpha.-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo3.2.1oct-3-yl ester, sulfate (2:1) (salt), monohydrate
  • ATROPINESULFATE,MONOHYDRATE,CP
  • ATROPINESULFATE,MONOHYDRATE,POWDER,USP
  • HYOSCYAMINE SULFATE(RG)
  • atropine sulfate crystalline
  • Atropine Sulfate (Monohydrate Salt)
  • α-(hydroxymethyl)-benzeneacetic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate, hydrate (2:1:1)
  • Benorilate Solution, 100ppm
  • ATRAZINE
  • ATROPINE SULFATE, MONOHYDRATE USP
  • alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate monohydrate
  • Atropine Sulfate Hydrate
  • Atropt
  • α-(Hydroxymethyl)benzeneacetic Acid (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl Ester Sulfate Hydrate
  • a-(Hydroxymethyl)benzeneacetic Acid (3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl Ester Sulfate Hydrate
  • Atropine sulphate monohydrate, 98+%
  • Tropine tropate, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • Atropine monohydrate sulfate salt
  • Atropini sulfas, Tropine tropate, α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • [(1S,5R)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate sulfuric acid hydrate
  • a-(Hydroxymethyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-(+/-)-, sulfate (2:1) (salt), monohydrate
  • Benzeneacetic acid, a-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, sulfate (2:1) (salt), monohydrate
  • 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (±)-tropate (ester), sulfate (2:1) salt monohydrate
  • α-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
  • AtropineSulfat
  • Atropine Sulfate (500 mg)
  • racemic anisodamine
  • Atropine sulfate monohydrate,98.5%
  • Atropine Sulfate RS
  • Atropine sulfate CRS
  • Atropine sulfate hydrate (2:1:1)
  • Atropine sulfate monohydrate USP/EP/BP
  • tropine sulfate monohydrate
  • (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
  • Atropine sulfate (A1400000)
  • [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
  • Atropine Sulfate (1045009)
  • ATROPINE SULPHATE MONOHYDRATE AR
  • Bis[(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl (2RS)-3-hydroxy-2-phenylpropanoate] sulfate monohydrate
  • atropiniumsulfat
  • Atropine Sulfate Atropine Sulfate Monohydrate