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Atropine sulfate

Product Name
Atropine sulfate
CAS No.
55-48-1
Chemical Name
Atropine sulfate
Synonyms
ATROPINE SULPHATE;atropinsulfat;Ryuato;eyesule;corbella;atropisal;NSC 26671;davurtrop;atropette;Tropintran
CBNumber
CB8315445
Molecular Formula
2C17H23NO3.H2O4S
Formula Weight
676.82
MOL File
55-48-1.mol
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Atropine sulfate Property

Melting point:
189-192 °C (A)(lit.)
Boiling point:
135 °C
Density 
1.1172 (rough estimate)
refractive index 
1.6900 (estimate)
storage temp. 
0-6°C
solubility 
Soluble in DMSO
form 
Solid
color 
Crystals
InChIKey
HOBWAPHTEJGALG-AADVZIIPNA-N
CAS DataBase Reference
55-48-1(CAS DataBase Reference)
EPA Substance Registry System
Atropine sulfate (55-48-1)
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Safety

Hazard Codes 
T+
Risk Statements 
26/28
Safety Statements 
23-45
RIDADR 
UN 1544 6.1/PG 2
WGK Germany 
2
3-8-10
Toxicity
LD50 oral in rat: 600mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-4835
Product name
Atropine Sulfate
Purity
98.07%
Packaging
100mg
Price
$60
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0006577
Product name
ATROPINE SULFATE
Purity
95.00%
Packaging
5MG
Price
$728
Updated
2021/12/16
Arctom
Product number
CFN90575
Product name
Atropine Sulfate
Packaging
20mg
Price
$198
Updated
2021/12/16
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Atropine sulfate Chemical Properties,Usage,Production

Uses

anticholinergic agent

Uses

cholinergic receptor antagonist

brand name

Atrophate [Veterinary] (Schering-Plough Animal Health); Atropisol (Ciba Vision, US Ophthalmics); Isopto Atropine (Alcon).

General Description

Atropine sulfate (Atropisol)is prepared by neutralizing atropine in acetone or ethersolution with an alcoholic solution of sulfuric acid, withcare used to prevent hydrolysis. The salt occurs as colorlesscrystals or as a white, crystalline powder. It is efflorescentin dry air and should be protected from light to preventdecomposition.
Atropine sulfate is freely soluble in water (1:0.5), in alcohol(1:5, 1:2.5 at boiling point), and in glycerin (1:2.5).Aqueous solutions are not very stable, although solutionsmay be sterilized at 120°C (15 lb pressure) in an autoclave if the pH is kept below 6. Sterilization probably is besteffected by the use of aseptic techniques and a bacteriologicalfilter. It has been suggested that no more than a 30-daysupply of an aqueous solution should be made and that forsmall quantities the best procedure is to use hypodermictablets and sterile distilled water. Kondritzer andZvirblis have studied the kinetics of alkaline and protoncatalyzedhydrolyses of atropine in aqueous solution. Theregion of maximal stability lies between pH 3 and approximately5. They have also proposed an equation to predictthe half-life of atropine undergoing hydrolysis at constantpH and temperature.

Clinical Use

Atropine may be used to treat some types of arrhythmias. Itincreases the heart rate by blocking the effects of ACh on thevagus. In this context, it is used to treat certain reversible bradyarrhythmiasthat may accompany acute myocardial infarction.It is also used as an adjunct to anesthesia to protect againstbradycardia, hypotension, and even cardiac arrest induced bythe skeletal muscle relaxant succinylcholine chloride.
Another use for atropine sulfate emerged following thedevelopment of the organophosphates, which are potent inhibitorsof AChE. Atropine is a specific antidote to preventthe muscarinic effects of ACh accumulation, such as vomiting,abdominal cramps, diarrhea, salivation, sweating, bronchoconstriction,and excessive bronchial secretions. It isused intravenously but does not protect against respiratoryfailure caused by depression of the respiratory center andthe muscles of respiration.

Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human (child) pulmonary system effects by ingestion. Human systemic effects: decreased body temperature, cardiac arrhythmias. An experimental teratogen. Other experimental reproductive effects. See also ATROPINE. When heated to decomposition it emits very toxic fumes of NO,xand SOx.

Veterinary Drugs and Treatments

The principal veterinary indications for systemic atropine include:
!!Preanesthetic to prevent or reduce secretions of the respiratory tract
!!Treat sinus bradycardia, sinoatrial arrest, and incomplete AV block
!!Differentiate vagally-mediated bradycardia for other causes
!!As an antidote for overdoses of cholinergic agents (e.g., physostigmine, etc.)
!!As an antidote for organophosphate, carbamate, muscarinic mushroom, blue-green algae intoxication
!!Hypersialism
!!Treatment of bronchoconstrictive disease

Atropine sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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Atropine sulfate Suppliers

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View Lastest Price from Atropine sulfate manufacturers

Henan Suikang Pharmaceutical Co.,Ltd.
Product
Atropine Sulphate 55-48-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99.0%
Supply Ability
1tons
Release date
2024-04-26
Baoji Guokang Bio-Technology Co., Ltd.
Product
Atropine sulfate 55-48-1
Price
US $450.00/KG
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
1000KG
Release date
2021-06-03
Hebei ZB Gamay Biological Technology Co.,Ltd
Product
Atropine sulfate 55-48-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98.00%
Supply Ability
1000kg
Release date
2022-12-10

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