Atropine sulfate

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Atropine sulfate

Product Name: Atropine sulfate
CAS No.: 55-48-1
Chemical Name: Atropine sulfate
Synonyms: ATROPINE SULPHATE;atropinsulfat;Ryuato;eyesule;corbella;atropisal;NSC 26671;davurtrop;atropette;Tropintran
CBNumber: CB8315445
Molecular Formula: 2C17H23NO3.H2O4S
Formula Weight: 676.82
MOL File: 55-48-1.mol

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Atropine sulfate Property

Melting point:: 189-192 °C (A)(lit.)
Boiling point:: 135 °C
Density: 1.1172 (rough estimate)
refractive index: 1.6900 (estimate)
storage temp.: 0-6°C
solubility: Soluble in DMSO
color: Crystals
InChIKey: HOBWAPHTEJGALG-AADVZIIPNA-N
CAS DataBase Reference: 55-48-1(CAS DataBase Reference)
EPA Substance Registry System: Atropine sulfate (55-48-1)

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Safety

Hazard Codes: T+
Risk Statements: 26/28
Safety Statements: 23-45
RIDADR: UN 1544 6.1/PG 2
WGK Germany: 2
F: 3-8-10
Toxicity: LD50 oral in rat: 600mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-4835
Product name: Atropine Sulfate
Purity: 98.07%
Packaging: 100mg
Price: $60
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006577
Product name: ATROPINE SULFATE
Purity: 95.00%
Packaging: 5MG
Price: $728
Updated: 2021/12/16

Arctom

Product number: CFN90575
Product name: Atropine Sulfate
Packaging: 20mg
Price: $198
Updated: 2021/12/16

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Atropine sulfate Chemical Properties,Usage,Production

Uses

anticholinergic agent

Uses

cholinergic receptor antagonist

brand name

Atrophate [Veterinary] (Schering-Plough Animal Health); Atropisol (Ciba Vision, US Ophthalmics); Isopto Atropine (Alcon).

General Description

Atropine sulfate (Atropisol)is prepared by neutralizing atropine in acetone or ethersolution with an alcoholic solution of sulfuric acid, withcare used to prevent hydrolysis. The salt occurs as colorlesscrystals or as a white, crystalline powder. It is efflorescentin dry air and should be protected from light to preventdecomposition.
Atropine sulfate is freely soluble in water (1:0.5), in alcohol(1:5, 1:2.5 at boiling point), and in glycerin (1:2.5).Aqueous solutions are not very stable, although solutionsmay be sterilized at 120°C (15 lb pressure) in an autoclave if the pH is kept below 6. Sterilization probably is besteffected by the use of aseptic techniques and a bacteriologicalfilter. It has been suggested that no more than a 30-daysupply of an aqueous solution should be made and that forsmall quantities the best procedure is to use hypodermictablets and sterile distilled water. Kondritzer andZvirblis have studied the kinetics of alkaline and protoncatalyzedhydrolyses of atropine in aqueous solution. Theregion of maximal stability lies between pH 3 and approximately5. They have also proposed an equation to predictthe half-life of atropine undergoing hydrolysis at constantpH and temperature.

Clinical Use

Atropine may be used to treat some types of arrhythmias. Itincreases the heart rate by blocking the effects of ACh on thevagus. In this context, it is used to treat certain reversible bradyarrhythmiasthat may accompany acute myocardial infarction.It is also used as an adjunct to anesthesia to protect againstbradycardia, hypotension, and even cardiac arrest induced bythe skeletal muscle relaxant succinylcholine chloride.
Another use for atropine sulfate emerged following thedevelopment of the organophosphates, which are potent inhibitorsof AChE. Atropine is a specific antidote to preventthe muscarinic effects of ACh accumulation, such as vomiting,abdominal cramps, diarrhea, salivation, sweating, bronchoconstriction,and excessive bronchial secretions. It isused intravenously but does not protect against respiratoryfailure caused by depression of the respiratory center andthe muscles of respiration.

Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human (child) pulmonary system effects by ingestion. Human systemic effects: decreased body temperature, cardiac arrhythmias. An experimental teratogen. Other experimental reproductive effects. See also ATROPINE. When heated to decomposition it emits very toxic fumes of NO,xand SOx.

Veterinary Drugs and Treatments

The principal veterinary indications for systemic atropine include:
!!Preanesthetic to prevent or reduce secretions of the respiratory tract
!!Treat sinus bradycardia, sinoatrial arrest, and incomplete AV block
!!Differentiate vagally-mediated bradycardia for other causes
!!As an antidote for overdoses of cholinergic agents (e.g., physostigmine, etc.)
!!As an antidote for organophosphate, carbamate, muscarinic mushroom, blue-green algae intoxication
!!Hypersialism
!!Treatment of bronchoconstrictive disease

Atropine sulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Atropine sulfate manufacturers

Shanghai Affida new material science and technology center

Product: Atropine sulfate API 55-48-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 10 tons
Release date: 2024-05-06

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Atropine Sulphate 55-48-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 1tons
Release date: 2024-04-26

Hebei ZB Gamay Biological Technology Co.,Ltd

Product: Atropine sulfate 55-48-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98.00%
Supply Ability: 1000kg
Release date: 2022-12-10

55-48-1, Atropine sulfateRelated Search:

Vanadyl sulfate CHLOROPHOSPHONAZO III Ammonium sulfate Methylparaben D-Glucosamine sulfate Aluminum sulfate Methyl acrylate Bensulfuron methyl Zinc sulfate heptahydrate Sodium sulfate PHENYL VALERATE Kresoxim-methyl 3-(4-Hydroxyphenyl)propionic acid Methyl sulfate Methyl bromide Parathion-methyl Atropine sulfate monohydrate

atropinysiarczan

atropisal

corbella

davurtrop

dl-tropanyl2-hydroxy-1-phenylpropionatesulfate

eyesule

Benzeneacetic acid, α-(hydroxymethyl)- 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-(+-)-, sulfate (2:1) (salt)

Benzeneacetic acid, α-(hydroxymethyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-, sulfate (2:1) (salt)

NSC 26671

Tropintran

ATROPINE SULFATE, FROM ATROPA BELLADONNA L.

ATROPINE SULFATE USP

Nitten Atropine

Ryuato

atropine sulfate Monohydrate Atropsiol

Atropine H2SO4

(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate

(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenyl-propanoate

atrpine sulfate monohydrate

1-alpha-h,5-alpha-h-tropan-3-alpha-ol(+-)-tropate(ester),sulfate(2:1)sal

atropette

atropine,sulfate(2:1)

atropiniumsulfate

atropinsal

atropinsiran

atropinsulfat

ichtho-bellol

lio-atropin

sulfated’atropine

sulfatropinol

alpha-(hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester sulfate monohydrate

(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenyl-propanoate sulphate

ATROPINE SULPHATE

ATROPINE SULFATE

ATROPINE SULFATE, ATROPA BELLADONNA (LINNAEUS)

Atropine Sulfate, Atropa belladonna L.

AtropineSulphatePuriss

Atropine sulfate std.

Benzeneacetic acid, .alpha.-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo3.2.1oct-3-yl ester, sulfate (2:1) (salt)

ATROPINE SULFATE(P)

1αH,5αH-Tropan-3α-ol (+-)-tropate (ester), sulfate (2:1) (salt) (8CI)

Atropisol Ophthalmic Solution

Benzeneacetic acid, α-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, sulfate (2:1) (salt)

Atropine sulfate monohydrat

Benzeneacetic acid, a-(hydroxymethyl)-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, sulfate (2:1) (salt)

Atropine sulfate USP/EP/BP

ATROPINE SULPHATE ANHYDROUS

Atropine SulphateQ: What is Atropine Sulphate Q: What is the CAS Number of Atropine Sulphate Q: What is the storage condition of Atropine Sulphate

Atropine sulfate API

3'-Dihydroxy-4'-methoxyacetophenone

Atropine sulfate Atropine

55-48-1

5808-99-6

C17H23NO22H2SO4

2C17H23NO3H2O4S

C17H25NO7S

Tropane Alkaloids

Alkaloids