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N6-CYCLOPENTYLADENOSINE

Product Name
N6-CYCLOPENTYLADENOSINE
CAS No.
41552-82-3
Chemical Name
N6-CYCLOPENTYLADENOSINE
Synonyms
UK-80882;N-CYCLOPENTYLADENOSINE;N6-CYCLOPENTYLADENOSINE;Adenosine, N-cyclopentyl-;N6-Cyclopentyladenosine,CPA;N(sup 6)-cyclopentyladenosine;N6-Cyclopentyladenosine;Adenosine A1 Receptor Agonist I, CPA;N6-Cyclopentyladenosine, 10 mM in DMSO;N6-Cyclopentyladenosine (CPA), A1 agonist
CBNumber
CB5779284
Molecular Formula
C15H21N5O4
Formula Weight
335.36
MOL File
41552-82-3.mol
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N6-CYCLOPENTYLADENOSINE Property

Melting point:
78.8 °C
Boiling point:
673.4±65.0 °C(Predicted)
Density 
1.78±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: soluble1.7mg/mL
form 
solid
pka
13.12±0.70(Predicted)
color 
white to off-white
Water Solubility 
H2O: 1.7mg/mL
0.1 M HCl: 12mg/mL
DMSO: 23mg/mL
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Safety

WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C8031
Product name
N6-Cyclopentyladenosine
Purity
solid
Packaging
25mg
Price
$84.4
Updated
2025/07/31
Sigma-Aldrich
Product number
C8031
Product name
N6-Cyclopentyladenosine
Purity
solid
Packaging
100mg
Price
$256
Updated
2025/07/31
Sigma-Aldrich
Product number
119135
Product name
Adenosine A1 Receptor Agonist I, CPA - CAS 41552-82-3 - Calbiochem
Packaging
25MG
Price
$78.8
Updated
2025/07/31
Cayman Chemical
Product number
21448
Product name
N6-Cyclopentyladenosine
Purity
≥99%
Packaging
10mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21448
Product name
N6-Cyclopentyladenosine
Purity
≥99%
Packaging
50mg
Price
$116
Updated
2024/03/01
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N6-CYCLOPENTYLADENOSINE Chemical Properties,Usage,Production

Uses

N6-Cyclopentyladenosine is a selective Adenosine A1-R agonist with Ki values of 2.3, 790 and 43 nM for human A1, A2A and A3 receptors respectively and EC50 value of 18600 nM for hA2B. It has also shown its efficacy against organophosphate toxcity.

Uses

N6-Cyclopentyladenosine has been used to study its effect on the cavernosal smooth muscle cells from lean and db/db (obesity and type II diabetes caused by a leptin receptor mutation) mice.

Biological Activity

Potent and selective adenosine A 1 receptor agonist (K i values are 2.3, 790 and 43 nM for human A 1 , A 2A and A 3 receptors respectively; EC 50 = 18600 nM for hA 2B ). Centrally active following systemic administration in vivo .

Biochem/physiol Actions

N6-Cyclopentyladenosine (CPA) is an adenosine derivative and a potent A1 adenosine receptor agonist. It acts as an anticonvulsant and might exhibit protective actions against aminophylline (AMPH)-induced seizures.

in vivo

N6-Cyclopentyladenosine (200 nmol/kg; i.p.; single dose; 22 h before 5-fluorouracil administration) protects the hematopoietic progenitor cells (CFC-GM) in the bone marrow from the cytotoxic damage of 5-fluorouracil (HY-90006) in the 5-fluorouracil-induced hematopoietic damage model of B10CBAF1 mice[4]. N6-Cyclopentyladenosine (1 mg/kg; i.p.) suppresses rapid eye movement (REM) sleep and enhances electroencephalographic slow wave activity during non-rapid eye movement (NREM) sleep in rats[5]. N6-Cyclopentyladenosine (0.15-2.25 μmol/kg; i.p.; single dose; 30 min before training) impairs the memory retention of passive avoidance tasks in mice in a dose-dependent manner in the mouse passive avoidance behavior experiment[6]. N6-Cyclopentyladenosine (2-4 mg/kg; i.p.; single dose; 15 min before aminophylline administration) delays the onset of aminophylline-induced clonic convulsions in the mouse model of aminophylline-induced recurrent generalized seizures, but cannot prevent the death of mice within 24 h[9].

storage

Desiccate at +4°C

N6-CYCLOPENTYLADENOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N6-CYCLOPENTYLADENOSINE Suppliers

China 60 Europe 1 Germany 3 Switzerland 2 United Kingdom 3 United States 13 Global 82
BIOTREND GmbH
Tel
--
Fax
--
Email
jaeger@biotrend.com
Country
Germany
ProdList
249
Advantage
65
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
BIOTREND Chemicals AG
Tel
--
Fax
--
Email
info@biotrend.ch
Country
Germany
ProdList
1250
Advantage
62

41552-82-3, N6-CYCLOPENTYLADENOSINERelated Search:

CYCLOPENTYLADENOSINE, 2-CHLORO-N6-[CYCLOPENTYL-2,3,4,5-3H]- (2S)-N6-[2-ENDO-NORBORNYL]ADENOSINE GR 79236 2'-MECCPA 2-CHLORO-N6-CYCLOPENTYLADENOSINE,2-CHLORO-N-CYCLOPENTYLADENOSINE N6-CYCLOPENTYLADENOSINE

  • N6-CYCLOPENTYLADENOSINE
  • N-CYCLOPENTYLADENOSINE
  • N(sup 6)-cyclopentyladenosine
  • (2R,3R,4S,5R)-2-(6-(CyclopentylaMino)-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
  • N<sup>6</sup>-Cyclopentyladenosine
  • Adenosine, N-cyclopentyl-
  • N6-Cyclopentyladenosine,CPA
  • UK-80882
  • N6 Cyclopentyladenosine,N6Cyclopentyladenosine,N-6-Cyclopentyladenosine
  • N6-Cyclopentyladenosine (CPA), A1 agonist
  • N6-Cyclopentyladenosine, 10 mM in DMSO
  • Adenosine A1 Receptor Agonist I, CPA
  • 41552-82-3
  • Adenosine receptor