4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE

Product Name: 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
CAS No.: 86030-08-2
Chemical Name: 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
Synonyms: BTB-1;NSC156750;BTB 1; BTB1;BTB-1 ，S6796;BTB-1, 10 mM in DMSO;LABOTEST-BB LT01147747;BTB 1 - NSC 156750 | NSC 658180;4-CHLORO-2-NITRODIPHENYL SULFONE;4-Chloro-2-nitrodiphenyl sulphone;4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
CBNumber: CB5783210
Molecular Formula: C12H8ClNO4S
Formula Weight: 297.71
MOL File: 86030-08-2.mol

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4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Property

Melting point:: 115 °C
Boiling point:: 471.2±35.0 °C(Predicted)
Density: 1.476±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO (30 mg/ml)
form: solid
color: White to off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2930909899

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B6581
Product name: BTB-1
Purity: min. 98.0 %
Packaging: 25MG
Price: $154
Updated: 2025/07/31

TCI Chemical

Product number: B6581
Product name: BTB-1
Purity: min. 98.0 %
Packaging: 100MG
Price: $387
Updated: 2025/07/31

Cayman Chemical

Product number: 27219
Product name: BTB-1
Packaging: 500mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 27219
Product name: BTB-1
Packaging: 1g
Price: $141
Updated: 2024/03/01

Cayman Chemical

Product number: 27219
Product name: BTB-1
Packaging: 250mg
Price: $40
Updated: 2024/03/01

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4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Chemical Properties,Usage,Production

Description

BTB-1 (86030-08-2) is a? selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 mM.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function.3 Inhibits the differentiation of mouse bone marrow cells to dendritic cells.4 Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.5

Uses

BTB 1 is a small molecular inhibitor of the mitotic motor protein Kif18A.

storage

Store at +4°C

References

[1] MARIO CATARINELLA. BTB-1: A Small Molecule Inhibitor of the Mitotic Motor Protein Kif18A†[J]. Angewandte Chemie International Edition, 2009, 48 48: 9072-9076. DOI:10.1002/anie.200904510
[2] JOACHIM BRAUN. Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A[J]. ACS Chemical Biology, 2014, 10 2: 554-560. DOI:10.1021/cb500789h
[3] JULIA LOCKE. Structural basis of human kinesin-8 function and inhibition.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2017: E9539-E9548. DOI:10.1073/pnas.1712169114
[4] Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells
[5] YONG-BIN CHO. Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 10: 5463-5475. DOI:10.1111/jcmm.15200

4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Suppliers

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86030-08-2, 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENERelated Search:

BENZYL ISOTHIOCYANATE Benzyl thiocyanate Methylene dithiocyanate 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE 4-CHLORO DIPHENYL SULFIDE 2-METHYLSULPHONYLANILINE HYDROCHLORIDE, 95 2-AMINO-4-CHLOROTHIOPHENOL 2-NITROPHENYL PHENYL SULFIDE Sulfenone 4-CHLORO-2-NITRO-1-(PHENYLTHIO)BENZENE 2-(Phenylthio)aniline 5-CHLORO-2-(METHYLTHIO)ANILINE 2-Nitrobiphenyl 2-(Phenylsulfonyl)aniline 2-Nitrophenyl phenyl sulfone 2-NITROTHIOANISOLE 2-Amino-4-chlorodiphenylsulfide 4-Chloro-2-Nitrothioanisole

LABOTEST-BB LT01147747

4-CHLORO-2-NITRODIPHENYL SULFONE

4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE

4-chloro-2-nitro-1-(phenylsulphonyl)benzene

1-Benzenesulfonyl-4-chloro-2-nitro-benzene

4-Chloro-2-nitrodiphenyl sulphone

BTB-1

BTB 1 - NSC 156750 | NSC 658180

BTB 1; BTB1

1-(2,4-dichlorophenyl)-1-cyclopropanecarboxylic acid

NSC156750

Benzene, 4-chloro-2-nitro-1-(phenylsulfonyl)-

Inhibitor,BTB-1,inhibit,BTB1,Microtubule/Tubulin

BTB-1, 10 mM in DMSO

BTB-1 ，S6796

86030-08-2