4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
- Product Name
- 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
- CAS No.
- 86030-08-2
- Chemical Name
- 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
- Synonyms
- BTB-1;NSC156750;BTB 1; BTB1;LABOTEST-BB LT01147747;BTB 1 - NSC 156750 | NSC 658180;4-CHLORO-2-NITRODIPHENYL SULFONE;4-Chloro-2-nitrodiphenyl sulphone;4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE;1-Benzenesulfonyl-4-chloro-2-nitro-benzene;4-chloro-2-nitro-1-(phenylsulphonyl)benzene
- CBNumber
- CB5783210
- Molecular Formula
- C12H8ClNO4S
- Formula Weight
- 297.71
- MOL File
- 86030-08-2.mol
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Property
- Melting point:
- 115 °C
- Boiling point:
- 471.2±35.0 °C(Predicted)
- Density
- 1.476±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO (30 mg/ml)
- form
- solid
- color
- White to off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2930909899
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
N-Bromosuccinimide Price
- Product number
- 27219
- Product name
- BTB-1
- Packaging
- 500mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 27219
- Product name
- BTB-1
- Packaging
- 1g
- Price
- $141
- Updated
- 2024/03/01
- Product number
- 27219
- Product name
- BTB-1
- Packaging
- 250mg
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 5399
- Product name
- BTB1
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $82
- Updated
- 2021/12/16
- Product number
- 5399
- Product name
- BTB1
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $345
- Updated
- 2021/12/16
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Chemical Properties,Usage,Production
Description
BTB-1 (86030-08-2) is a? selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 mM.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function.3 Inhibits the differentiation of mouse bone marrow cells to dendritic cells.4 Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.5
Uses
BTB 1 is a small molecular inhibitor of the mitotic motor protein Kif18A.
storage
Store at +4°C
References
Catarinella et al. (2009), BTB-1; a small molecule inhibitor of the mitotic motor protein Kif18A; Chem. Int. Ed. Engl., 48 9072 Braun et al. (2015), Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A; ACS Chem. Biol., 10 554 Locke et al. (2017), Structural basis of human kinesin-8 function and inhibition; Proc. Natl. Acad. Sci. USA, 114 E9539 Kim et al. (2020), Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells; Genes Genomics, 42 41 Cho et al. (2020), Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus; J. Cell Mol. Med., 24 5463