ChemicalBook > CAS DataBase List > 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE

4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE

Product Name
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
CAS No.
86030-08-2
Chemical Name
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
Synonyms
BTB-1;NSC156750;BTB 1; BTB1;BTB-1 ，S6796;BTB-1, 10 mM in DMSO;LABOTEST-BB LT01147747;BTB 1 - NSC 156750 | NSC 658180;4-CHLORO-2-NITRODIPHENYL SULFONE;4-Chloro-2-nitrodiphenyl sulphone;4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
CBNumber
CB5783210
Molecular Formula
C12H8ClNO4S
Formula Weight
297.71
MOL File
86030-08-2.mol
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4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Property

Melting point:
115 °C
Boiling point:
471.2±35.0 °C(Predicted)
Density 
1.476±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (30 mg/ml)
form 
solid
color 
White to off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2930909899
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B6581
Product name
BTB-1
Purity
min. 98.0 %
Packaging
25MG
Price
$154
Updated
2025/07/31
TCI Chemical
Product number
B6581
Product name
BTB-1
Purity
min. 98.0 %
Packaging
100MG
Price
$387
Updated
2025/07/31
Cayman Chemical
Product number
27219
Product name
BTB-1
Packaging
500mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
27219
Product name
BTB-1
Packaging
1g
Price
$141
Updated
2024/03/01
Cayman Chemical
Product number
27219
Product name
BTB-1
Packaging
250mg
Price
$40
Updated
2024/03/01
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4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Chemical Properties,Usage,Production

Description

BTB-1 (86030-08-2) is a? selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 mM.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function.3 Inhibits the differentiation of mouse bone marrow cells to dendritic cells.4 Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.5

Uses

BTB 1 is a small molecular inhibitor of the mitotic motor protein Kif18A.

storage

Store at +4°C

References

[1] MARIO CATARINELLA. BTB-1: A Small Molecule Inhibitor of the Mitotic Motor Protein Kif18A†[J]. Angewandte Chemie International Edition, 2009, 48 48: 9072-9076. DOI:10.1002/anie.200904510
[2] JOACHIM BRAUN. Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A[J]. ACS Chemical Biology, 2014, 10 2: 554-560. DOI:10.1021/cb500789h
[3] JULIA LOCKE. Structural basis of human kinesin-8 function and inhibition.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2017: E9539-E9548. DOI:10.1073/pnas.1712169114
[4] Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells
[5] YONG-BIN CHO. Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 10: 5463-5475. DOI:10.1111/jcmm.15200

4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Suppliers

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86030-08-2, 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENERelated Search:

BENZYL ISOTHIOCYANATE Benzyl thiocyanate Methylene dithiocyanate 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE 4-CHLORO DIPHENYL SULFIDE 2-METHYLSULPHONYLANILINE HYDROCHLORIDE, 95 2-AMINO-4-CHLOROTHIOPHENOL 2-NITROPHENYL PHENYL SULFIDE Sulfenone 4-CHLORO-2-NITRO-1-(PHENYLTHIO)BENZENE 2-(Phenylthio)aniline 5-CHLORO-2-(METHYLTHIO)ANILINE 2-Nitrobiphenyl 2-(Phenylsulfonyl)aniline 2-Nitrophenyl phenyl sulfone 2-NITROTHIOANISOLE 2-Amino-4-chlorodiphenylsulfide 4-Chloro-2-Nitrothioanisole

  • LABOTEST-BB LT01147747
  • 4-CHLORO-2-NITRODIPHENYL SULFONE
  • 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
  • 4-chloro-2-nitro-1-(phenylsulphonyl)benzene
  • 1-Benzenesulfonyl-4-chloro-2-nitro-benzene
  • 4-Chloro-2-nitrodiphenyl sulphone
  • BTB-1
  • BTB 1 - NSC 156750 | NSC 658180
  • BTB 1; BTB1
  • 1-(2,4-dichlorophenyl)-1-cyclopropanecarboxylic acid
  • NSC156750
  • Benzene, 4-chloro-2-nitro-1-(phenylsulfonyl)-
  • Inhibitor,BTB-1,inhibit,BTB1,Microtubule/Tubulin
  • BTB-1, 10 mM in DMSO
  • BTB-1 ，S6796
  • 86030-08-2