8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE

Product Name: 8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE
CAS No.: 898832-40-1
Chemical Name: 8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE
Synonyms: 8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine;2H-1,4-Benzoxazine, 8-fluoro-3,4-dihydro-;8-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine;8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine 1HCl salt;8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE
CBNumber: CB5805264
Molecular Formula: C8H8FNO
Formula Weight: 153.15
MOL File: 898832-40-1.mol

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8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE Property

Boiling point:: 238℃
Density: 1.200
Flash point:: 98℃
storage temp.: Sealed in dry,Room Temperature
Appearance: Brown to reddish brown Liquid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F595263
Product name: 8-Fluoro-3,4-dihydro-2H-1,4-benzoxazine
Packaging: 100mg
Price: $115
Updated: 2021/12/16

Apolloscientific

Product number: PC910934
Product name: 8-Fluoro-3,4-dihydro-2H-1,4-benzoxazine
Purity: 98%
Packaging: 1g
Price: $330
Updated: 2021/12/16

AK Scientific

Product number: 4915AC
Product name: 8-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine
Packaging: 1g
Price: $384
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0352633
Product name: 8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE
Purity: 95.00%
Packaging: 5MG
Price: $505.8
Updated: 2021/12/16

AK Scientific

Product number: 4915AC
Product name: 8-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine
Packaging: 5g
Price: $1051
Updated: 2021/12/16

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8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

560082-51-1

898832-40-1

8-Fluoro-2H-1,4-benzoxazin-3(4H)-one (1.0 g, 5.9 mmol) was used as starting material, which was dissolved in THF (25 mL) and stirred to form a suspension at 0 °C to -5 °C. Subsequently, a THF solution of lithium aluminum hydride (7 mL, 1 M) was slowly added dropwise. After the dropwise addition, the reaction mixture was warmed to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the mixture was carefully poured into ice water to quench the reaction and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to remove the solvent. The resulting residue was ground with ether to afford 8-fluoro-3,4-dihydro-2H-benzo[1,4]oxazine (0.8 g, 87% yield) as a dark brown solid. Mass spectrum (ESI+): m/z 154 [M+H]+. 1H NMR (DMSO-d6): δ 3.27 (2H, m), 4.11 (2H, m), 6.05 (1H, br s), 6.34 (2H, m), 6.58 (1H, m).

References

[1] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 30
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 16, p. 4700 - 4704

8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE Suppliers

China 29 Europe 1 India 2 United States 7 Global 39

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898832-40-1, 8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDERelated Search:

Oxygen-fluorine acid 6-BROMO-8-FLUORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE Levofloxacin carboxylic acid 8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE 6,8-DIFLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE 8-FLUORO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate AKOS 1305 BUTTPARK 120\07-80 9,10-Difluoro-2,3-dihydro-2-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine 1HCl salt

8-FLUORO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE

8-Fluoro-3,4-dihydro-2H-benzo[1,4]oxazine

2H-1,4-Benzoxazine, 8-fluoro-3,4-dihydro-

8-Fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine

898832-40-1