Enfortumab Vedotin
- Product Name
- Enfortumab Vedotin
- CAS No.
- 1346452-25-2
- Chemical Name
- Enfortumab Vedotin
- Synonyms
- Enfortumab;Enfortumab Vedotin;Research Grade Enfortumab;Research Grade Enfortumab(DHJ41001);Enfortumab vedotin-ejfv (anti-Nectin-4)
- CBNumber
- CB58080892
- Formula Weight
- 0
- MOL File
- Mol file
Enfortumab Vedotin Property
- form
- Liquid
- color
- Colorless to light yellow
Enfortumab Vedotin Chemical Properties,Usage,Production
Uses
Enfortumab vedotin-ejfv (solution) is an anti-Nectin-4 antibody-drug conjugate. Enfortumab vedotin-ejfv is a fully humanized IgG1 antibody conjugated to the microtubule disrupting agent MMAE (HY-15162) via a protease-cleavable maleimidocaproylvaline-citrulline linker (SGD-1006). Nectin-4 is an adhesion protein involved in cellular processes and tumorigenesis, and Enfortumab vedotin-ejfv is indicated for the inhibition of locally advanced or metastatic urothelial carcinoma[1][2].
Synthesis
Synthesis of enfortumab vedotin
References
[1] Halford Z, et al. Enfortumab Vedotin-ejfv: A First-in-Class Anti-Nectin-4 Antibody-Drug Conjugate for the Management of Urothelial Carcinoma. Ann Pharmacother. 2021 Jun;55(6):772-782. DOI:10.1177/1060028020960402
[2] Chang E, et al. FDA Approval Summary: Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Carcinoma. Clin Cancer Res. 2021 Feb 15;27(4):922-927. DOI:10.1158/1078-0432.CCR-20-2275
Enfortumab Vedotin Preparation Products And Raw materials
Raw materials
Preparation Products
Enfortumab Vedotin Suppliers
- Tel
- +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19961
- Advantage
- 58