Refanezumab
- Product Name
- Refanezumab
- CAS No.
- 1233953-61-1
- Chemical Name
- Refanezumab
- Synonyms
- Refanezumab;Refanezumab (anti-MAG);Research Grade Refanezumab;Research Grade Refanezumab(DHD43401)
- CBNumber
- CB58080968
- Formula Weight
- 0
- MOL File
- Mol file
Refanezumab Property
- form
- Liquid
- color
- Colorless to light yellow
N-Bromosuccinimide Price
- Product number
- A495
- Product name
- Refanezumab Biosimilar（Anti-Siglec-4a / MAG Reference Antibody）
- Purity
- >98%
- Packaging
- 1mg
- Price
- $450
- Updated
- 2026/05/24
- Product number
- A495
- Product name
- Refanezumab Biosimilar（Anti-Siglec-4a / MAG Reference Antibody）
- Purity
- >98%
- Packaging
- 5mg
- Price
- $750
- Updated
- 2026/05/24
- Product number
- A495
- Product name
- Refanezumab Biosimilar（Anti-Siglec-4a / MAG Reference Antibody）
- Purity
- >98%
- Packaging
- 10mg
- Price
- $1100
- Updated
- 2026/05/24
- Product number
- A495
- Product name
- Refanezumab Biosimilar（Anti-Siglec-4a / MAG Reference Antibody）
- Purity
- >98%
- Packaging
- 20mg
- Price
- $1300
- Updated
- 2026/05/24
- Product number
- A495
- Product name
- Refanezumab Biosimilar（Anti-Siglec-4a / MAG Reference Antibody）
- Purity
- >98%
- Packaging
- 50mg
- Price
- $1600
- Updated
- 2026/05/24
Refanezumab Chemical Properties,Usage,Production
Uses
Refanezumab (GSK249320) is an IgG1-type humanized monoclonal antibody directed against myelin-associated glycoprotein (MAG). Refanezumab binds to MAG and blocks MAG-mediated inhibition of axonal regeneration. Refanezumab can cross the blood-brain barrier (BBB) in animal stroke models. Refanezumab has the potential for the enhancement of recovery of function poststroke[1][2].
in vivo
Refanezumab (GSK249320; 10 mg/kg; IV; starting 24 hours post-stroke and continuing weekly for 6 more doses) shows larger increases in neuroscore and staircase test. Refanezumab by intravenous penetrates the lesion site and is associated with a small effect on functional outcomes when initiated 24 hours post-stroke[1].
| Animal Model: | Male Sprague Dawley rats (weight 361g)[1] |
| Dosage: | 10 mg/kg |
| Administration: | IV; starting 24 hours post-stroke and continuing weekly for 6 more doses; starting seven days post-stroke and continuing weekly for 5 more doses |
| Result: | Animals treated 24 hours post-stroke showed larger increases in neuroscore and staircase test as compared to controls, but animals treated 7 days post-stroke showed no significant behavioral benefit. |
References
[1] Diana Cash, et al. GSK249320, A Monoclonal Antibody Against the Axon Outgrowth Inhibition Molecule Myelin-Associated Glycoprotein, Improves Outcome of Rodents with Experimental Stroke. J Neurol Exp Neurosci. 2016;2(2):28-33. Epub 2016 Nov 21. PMID:28018988
[2] B Abila, et al. First-time-in-human study with GSK249320, a myelin-associated glycoprotein inhibitor, in healthy volunteers. Clin Pharmacol Ther. 2013 Feb;93(2):163-9. DOI:10.1038/clpt.2012.227
Refanezumab Preparation Products And Raw materials
Raw materials
Preparation Products
Refanezumab Suppliers
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 89686
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 7999
- Advantage
- 62
- Tel
- 15817493340
- 981810490@qq.com
- Country
- China
- ProdList
- 1566
- Advantage
- 58
- Tel
- 027-65317797 15926423062
- Fax
- QQ：422450190
- 422450190@qq.com
- Country
- China
- ProdList
- 10308
- Advantage
- 58
- Tel
- 4008200310 15002144251
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24955
- Advantage
- 58
- Tel
- 027-65279366 18108604356
- products@biolabreagent.com
- Country
- China
- ProdList
- 9865
- Advantage
- 58
- Tel
- 13720134139 086-15871494362 13720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 7081
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 11972
- Advantage
- 58
- Tel
- 6206333 13167063860
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 49998
- Advantage
- 58
- Tel
- 15111215862 18229892877
- 3062105966@qq.com
- Country
- China
- ProdList
- 5432
- Advantage
- 58