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Panobacumab

Product Name
Panobacumab
CAS No.
885053-97-4
Chemical Name
Panobacumab
Synonyms
Panobacumab;Research Grade Panobacumab;Research Grade Panobacumab(DXX02101)
CBNumber
CB98080784
Formula Weight
0
MOL File
Mol file
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Panobacumab Property

form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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Panobacumab Chemical Properties,Usage,Production

Uses

Panobacumab (KBPA101) is a fully human IgM/κ monoclonal antibody generated by immortalizing human B lymphocytes against the LPS O polysaccharide of serotype O11 of P. aeruginosa[1].

in vivo

Panobacumab (KBPA101) (1-4 mg/kg; i.v.; once) protects mice from systemic infection with P. aeruginosa serotype O11 in a murine burn wound model[1].
Panobacumab (KBPA101) (0.005-0.4 mg/kg; i.v.; once) protects mice from local lung infection with P. aeruginosa serotype O11 in an acute lung infection model[1].

Animal Model:Female NMRI mice, murine burn wound model[1]
Dosage:1, 2, or 4 mg/kg
Administration:Intravenous injection, single dose
Result:Significantly reduced mortality compared to untreated control animals administered either immediately or 4 h postchallenge.
Animal Model:BALB/c mice, acute lung infection model[1]
Dosage:0.005 to 0.4 mg/kg
Administration:Intravenous injection, single dose
Result:Led to rapid clearance of P. aeruginosa from the lung, completely cleared systemic P. aeruginosa from the spleen, whereas live bacteria were still present in untreated mice at 48 h postchallenge, showed milder macroscopic lung pathology at 6 and 24 h after infection.

References

[1] Horn MP, et al. Preclinical in vitro and in vivo characterization of the fully human monoclonal IgM antibody KBPA101 specific for Pseudomonas aeruginosa serotype IATS-O11. Antimicrob Agents Chemother. 2010 Jun;54(6):2338-44. DOI:10.1128/AAC.01142-09

Panobacumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Panobacumab Suppliers

China 13 Global 13
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Guangzhou Hongyuan Chemical Co.,Ltd
Tel
15817493340
Email
981810490@qq.com
Country
China
ProdList
1566
Advantage
58
Wuhan Chemstan Biotechnology Co., Ltd.
Tel
027-65317797 15926423062
Fax
QQ：422450190
Email
422450190@qq.com
Country
China
ProdList
10308
Advantage
58
Biolab Reagents
Tel
027-65279366 18108604356
Email
products@biolabreagent.com
Country
China
ProdList
9868
Advantage
58
Wuhan Jingkangen Biomedical Technology Co., Ltd
Tel
13720134139 086-15871494362 13720134139
Email
orders@jknbiochem.com
Country
China
ProdList
6762
Advantage
58
Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11973
Advantage
58
Changsha Fuzhen Biotechnology Co.，LTD
Tel
0731-13823398 15111215862
Email
313359644@qq.com
Country
China
ProdList
4161
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58
Wanxin Biotechnology (Jiaxing) Co., LTD
Tel
0573-83568680 18057391398
Email
3956524501@qq.com
Country
China
ProdList
1442
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58
Atagenix Laboratories
Tel
027-87008169 17762441161
Email
info@atagenix.com
Country
China
ProdList
10001
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58
AntibodySystem Laboratories SAS
Tel
33175446423
Email
support@antibodysystem.com
Country
China
ProdList
6739
Advantage
58

885053-97-4, PanobacumabRelated Search:

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  • Panobacumab
  • Research Grade Panobacumab(DXX02101)
  • Research Grade Panobacumab
  • 885053-97-4