Emactuzumab
- Product Name
- Emactuzumab
- CAS No.
- 1448221-67-7
- Chemical Name
- Emactuzumab
- Synonyms
- Emactuzumab;RO 5509554|||RG 7155;Emactuzumab (anti-CSF1R);Research Grade Emactuzumab;Research Grade Emactuzumab(DHC25202)
- CBNumber
- CB98080911
- Formula Weight
- 0
- MOL File
- Mol file
Emactuzumab Property
- form
- Liquid
- color
- Colorless to light yellow
Emactuzumab Chemical Properties,Usage,Production
Uses
Emactuzumab(RG 7155) is a specific monoclonal antibody that inhibits colonystimulating factor 1 receptor (CSF1R) activation. Emactuzumab has high affinity for CSF-1R with Ki value of 0.2 nM to blocks CSF-1R dimerization. Emactuzumab can be used for the research of several diseases, such as diffuse-type tenosynovial giant cell tumour (dt-GCT) [1][2].
in vivo
Emactuzumab(RG 7155) (i.v.; 0.1, 1, 10, 30 and 100 mg/kg; once) increases CSF-1 concentration in nonhuman primates’ peripheral blood[2].
RG7155 (i.v.; 0, 30, and 100 mg/kg; once weekly; for 2 weeks) depletes CSF-1R+CD163+ macrophages in vivo[2].
| Animal Model: | cynomolgus monkeys Macaca fascicularis[2] |
| Dosage: | 0.1, 1, 10, 30 and 100 mg/kg (male cynomolgus monkeys) 0, 30, and 100 mg/kg (male and female cynomolgus) |
| Administration: | i.v., once (male cynomolgus monkeys) i.v., once weekly, for 2 weeks(male and female cynomolgus) |
| Result: | Increased CSF-1 concentration in serum. Efficiently reduced CSF-1R and CD68+163+ macrophages in the liver (Kupffer cells) and colon of cynomologus monkeys. |
References
[1] Philippe A Cassier, et al. CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study. Lancet Oncol. 2015 Aug;16(8):949-56. DOI:10.1016/S1470-2045(15)00132-1
[2] Carola H Ries, et al. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell. 2014 Jun 16;25(6):846-59. DOI:10.1016/j.ccr.2014.05.016
Emactuzumab Preparation Products And Raw materials
Raw materials
Preparation Products
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