Semorinemab

Product Name: Semorinemab
CAS No.: 2159141-27-0
Chemical Name: Semorinemab
Synonyms: Semorinemab;Semorinemab (anti-Tau);Research Grade Semorinemab;Research Grade Semorinemab(DHC82404)
CBNumber: CB58081147
Formula Weight: 0
MOL File: Mol file

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Semorinemab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Semorinemab Chemical Properties,Usage,Production

Uses

Semorinemab (RG 6100) is an anti-Tau humanized IgG4 monoclonal antibody, targets the N-terminal portion of the Tau protein (amino acid residues 6-23). Semorinemab binds with human Tau with a Kd value of 3.8 nM. Semorinemab can be used for the research of Alzheimer's Disease[1].

in vivo

Semorinemab (3, 10 and 30 mg/kg; i.p., once weekly for 13 weeks) reduces accumulation of Tau pathology in a transgenic (Tg) mouse model of tauopathy^[1].

Animal Model:	Tg mouse with the expression of human disease-causing tau mutant (TauP301L-Tg) ^[1]
Dosage:	3, 10 and 30 mg/kg
Administration:	Intraperitoneal injection; 3, 10 and 30 mg/kg, once weekly for 13 weeks
Result:	Reduced the accumulation of pathological tau, and dose-dependently decreased pTau212/214 and pTau202/205.

References

[1] Ayalon G, et al. Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease. Sci Transl Med. 2021 May 12;13(593):eabb2639. DOI:10.1126/scitranslmed.abb2639

Semorinemab Preparation Products And Raw materials

Raw materials

Preparation Products

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Semorinemab Suppliers

China 15 Global 15

Shanghai YuanYe Biotechnology Co., Ltd.

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Biolab Reagents

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Atagenix Laboratories

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Semorinemab

Research Grade Semorinemab(DHC82404)

Research Grade Semorinemab

Semorinemab (anti-Tau)

2159141-27-0