Tigatuzumab

Product Name: Tigatuzumab
CAS No.: 918127-53-4
Chemical Name: Tigatuzumab
Synonyms: Tigatuzumab;Research Grade Tigatuzumab;Tigatuzumab (anti-TNFRSF10B);Research Grade Tigatuzumab (DHA29102)
CBNumber: CB98080779
Formula Weight: 0
MOL File: Mol file

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Tigatuzumab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Tigatuzumab Chemical Properties,Usage,Production

Uses

Tigatuzumab (CS-1008) is a humanized IgG1 monoclonal antibody targets death receptor 5 (DR5). Tigatuzumab induces cell apoptosis of cancer cells and inhibits tumor growth in vivo. Tigatuzumab can be used for the research of cancer[1].

in vivo

Tigatuzumab (3 mg/kg; i.v. weekly for 4 weeks) effectively represses the tumor growth in human pancreatic cancer MIA PaCa-2-RFP orthotopic mouse model^[1].

Animal Model:	Nude mice with MIA PaCa-2-RFP human pancreatic cancer cells injection^[1]
Dosage:	3 mg/kg
Administration:	Intravenous injection; 3 mg/kg weekly for 4 weeks
Result:	Reduced the tumor volume and decreased the density of viable cancer cells in tumors.

References

[1] Yamamoto J, et al. Oral recombinant methioninase increases TRAIL receptor-2 expression to regress pancreatic cancer in combination with agonist tigatuzumab in an orthotopic mouse model. Cancer Lett. 2020 Nov 1;492:174-184. DOI:10.1016/j.canlet.2020.07.034

Tigatuzumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Tigatuzumab Suppliers

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Tigatuzumab (anti-TNFRSF10B)

918127-53-4