(6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE

Product Name: (6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE
CAS No.: 1227675-51-5
Chemical Name: (6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE
Synonyms: SCH 39166 HYDROBROMIDE;(6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE
CBNumber: CB5828599
Molecular Formula: C19H21BrClNO
Formula Weight: 394.74
MOL File: Mol file

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(6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE Property

storage temp.: Desiccate at RT
solubility: DMSO: Slightly Soluble; Methanol: Slightly Soluble; Water: Slightly Soluble
form: A solid
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2591
Product name: SCH-39166 hydrobromide
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $126
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2591
Product name: SCH-39166 hydrobromide
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $509
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2591
Product name: SCH-39166 hydrobromide
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2591
Product name: SCH-39166 hydrobromide
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $495
Updated: 2024/03/01

Cayman Chemical

Product number: 25331
Product name: SCH 39166 (hydrobromide)
Purity: ≥98%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

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(6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE Chemical Properties,Usage,Production

Description

SCH 39166 is a dopamine D₁ receptor antagonist (K_i = 5 nM). It is selective for D₁ over D_2-4 receptors (K_is = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D₅ receptors (K_i = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED₅₀ = 0.84 mg/kg). It reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake. SCH 39166 also suppresses cocaine-induced arrhythmias in anesthetized dogs.

Uses

SCH 39166 is a dopamine D1/D5 receptor antagonist used in the treatment of schizophrenia, cocaine addiction and obesity.

storage

Desiccate at RT

References

[1] M.A.B. TICE. Characterization of the binding of SCH 39166 to the five cloned dopamine receptor subtypes[J]. Pharmacology Biochemistry and Behavior, 1994, 49 3: Pages 567-571. DOI: 10.1016/0091-3057(94)90070-1
[2] P TERRY J L K. A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behavior by the D1 agonist SKF38393.[J]. Psychopharmacology, 1994, 113 3-4: 328-333. DOI: 10.1007/bf02245205
[3] I PANOCKA. Effects of the dopamine D1 receptor antagonist SCH 39166 on the ingestive behaviour of alcohol-preferring rats.[J]. Psychopharmacology, 1995, 120 2: 227-235. DOI: 10.1007/bf02246198
[4] P M KANANI. Acute deleterious effects of cocaine on cardiac conduction, hemodynamics, and ventricular fibrillation threshold: effects of interaction with a selective dopamine D1 antagonist SCH 39166.[J]. Journal of Cardiovascular Pharmacology, 1998, 32 1: 42-48. DOI: 10.1097/00005344-199807000-00007

(6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE Suppliers

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1227675-51-5, (6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDERelated Search:

SCH 39166 HYDROBROMIDE

(6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE

1227675-51-5

C19H20ClNOHBr

Dopamine receptor