ChemicalBook > CAS DataBase List > 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE

1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE

Product Name: 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE
CAS No.: 10394-38-4
Chemical Name: 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE
Synonyms: NSC 240760;1-Methylbenzimidazol-5-amine;5-Amino-1-methylbenzimidazole;1-Methylbenzoimidazol-5-amine;1-Methyl-5-aminobenzimidazole;1-methylbenzimidazole-5-amine;1-methyl-1H-benzimidazol-5-amine;5-Amino-1-methyl-1H-benzimidazole;5-Amino-1-methylbenzimidazole,97%;1-Methyl-1H-1,3-benzodiazol-5-aMine
CBNumber: CB5835122
Molecular Formula: C8H9N3
Formula Weight: 147.18
MOL File: 10394-38-4.mol

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1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE Property

Melting point:: 158-159 °C
Boiling point:: 348.6±34.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: Solid
pka: 6.35±0.10(Predicted)
Appearance: Light brown to black Solid

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Safety

Risk Statements: 41
Safety Statements: 26-39
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Apolloscientific

Product number: OR301135
Product name: 5-Amino-1-methyl-1H-benzimidazole
Packaging: 250mg
Price: $56
Updated: 2021/12/16

Matrix Scientific

Product number: 076429
Product name: 1-Methylbenzoimidazol-5-amine
Purity: 95+%
Packaging: 250mg
Price: $278
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-35
Product name: 1-Methylbenzoimidazol-5-amine
Purity: 95%
Packaging: 1g
Price: $164
Updated: 2021/12/16

AK Scientific

Product number: X8683
Product name: 1-Methyl-1H-benzo[d]imidazol-5-amine
Packaging: 1g
Price: $170
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-35
Product name: 1-Methylbenzoimidazol-5-amine
Purity: 95%
Packaging: 250mg
Price: $66
Updated: 2021/12/16

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1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

1-Methyl-5-aminobenzimidazole is used in the synthesis of usnic acid derivatives as tau-aggregation and neuroinflammation inhibitor.

Synthesis

5381-78-2

10394-38-4

Example B23: 1-methyl-5-nitro-1H-benzo[d]imidazole (prepared according to the method described in WO 2005/092899; 1.14 g, 6.43 mmol) was dissolved in ethanol (50 ml) and stirred at room temperature under hydrogen (1 atm) atmosphere. 10% Pd/C catalyst (50 wt% water, 1.37 g, 0.643 mmol) was added. After 18 h of reaction, the reaction mixture was filtered through diatomaceous earth and rinsed with ethanol. The filtrates were combined and concentrated to afford the crude product 1-methyl-1H-benzo[d]imidazol-5-amine (1.02 g, 108% yield) as a dark orange oil, which was used directly in the next step of the reaction.1H NMR (400 MHz, DMSO-d6) δ 7.87 (s, 1H), 7.17 (d, J=8.4 Hz, 1H), 6.75 (d, J=2.0 Hz, 1H), 6.59 (dd, J=2.0 and 8.4 Hz, 1H), 4.73 (brs, 2H), 3.69 (s, 3H); MS (ESI) m/z: 148.0 (M+H+). Using a method similar to Example B22, 1-methyl-1H-benzo[d]imidazol-5-amine (0.50 g, 3.4 mmol), NaNO2 (0.28 g, 4.1 mmol), SnCl2-2H2O (2.8 g, 14 mmol), and 4-methyl-3-oxopentanenitrile (0.45 g, 4.1 mmol) were reacted to give the crude product 3-Isopropyl-1-(1-methyl-1H-benzo[d]imidazol-5-yl)-1H-pyrazol-5-amine (0.63 g, 73% yield), as a foam, was used directly in the next step of the reaction.1H NMR (400 MHz, DMSO-d6): δ 8.22 (s, 1H), 7.72 (dd, J=0.40 and 1.2 Hz, 1H), and 7.60 (dd, J=0.40 and 8.4 Hz, 1H), 7.42 (dd, J=2.0 and 8.4 Hz, 1H), 5.32 (s, 1H), 5.08 (brs, 2H), 3.85 (s, 3H), 2.75 (septet, J=6.8 Hz, 1H), 1.16 (d, J=6.8 Hz, 6H); MS ( ESI) m/z: 250.0 (M+H+).

References

[1] Patent: US2008/90856, 2008, A1. Location in patent: Page/Page column 46-47
[2] Patent: US2007/27184, 2007, A1. Location in patent: Page/Page column 20
[3] Journal of Pharmacy and Pharmacology, 1951, vol. 3, p. 420,424
[4] Gazzetta Chimica Italiana, 1955, vol. 85, p. 981,984
[5] Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 3, p. 713 - 724

1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE 10394-38-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-20

10394-38-4, 1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDERelated Search:

1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE Clonitazene etonitazene Bendamustine hydrochloride Bendamustine 1H-BENZOIMIDAZOL-5-YLAMINE 1H-Benzimidazole,1-methyl-5-nitro-(9CI) BIO-FARMA BF002412 CHEMBRDG-BB 5663117 1-ETHYL-2-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE 1-BENZYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE (1,2-DIMETHYL-1H-BENZOIMIDAZOL-5-YL)-(4-ETHOXY-BENZYL)-AMINE 2-ACETYL-3-([1-(4-CHLOROPHENYL)-1H-BENZIMIDAZOL-5-YL]AMINO)ACRYLONITRILE 1-(4-METHOXY-BENZYL)-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE 4-(5-AMINO-BENZOIMIDAZOL-1-YL)-BUTAN-1-OL 2-(3-(1,3-DIETHYL-5-NITRO-1H-2(3H)-BENZIMIDAZOLIDENE)-1-PROPENYL)-1,3-DIETHYL-5-NITRO-1H-BENZIMIDAZOLIUM 4-TOLUENESULFONATE N-{4-[5-(ACETYLAMINO)-1-PHENYL-1H-BENZIMIDAZOL-2-YL]PHENYL}ACETAMIDE 1-Ethyl-2-methyl-1H-benzoimidazol-5-ylaminedihydrochloride

1-METHYL-1H-BENZOIMIDAZOL-5-YLAMINE TRIHYDROCHLORIDE

1H-Benzimidazol-5-amine,1-methyl-(9CI)

1-methyl-1H-benzimidazol-5-amine

1-Methylbenzoimidazol-5-amine

1-methyl-1H-benzimidazol-5-amine hydrochloride

1-methyl-1H-benzimidazol-5-amine(SALTDATA: FREE)

1-Methyl-1H-benzo[d]iMidazol-5-aMine

1-Methyl-1H-1,3-benzodiazol-5-aMine

1-Methyl-1H-benzo[d]iMidazol-5-YaMine

5-Amino-1-methyl-1H-benzimidazole

5-Amino-1-methylbenzimidazole

NSC 240760

1-Methyl-5-aminobenzimidazole

1H-Benzimidazol-5-amine, 1-methyl-, 95%

1-methyl-5-benzimidazolamine trihydrochloride

1-Methylbenzimidazol-5-amine

5-Amino-1-methylbenzimidazole,97%

1-methylbenzimidazole-5-amine

10394-38-4

amine

BENZIMIDAZOLE